A5049905720- Nanoparticle-Based Drug Delivery
- Facial Nerve Paralysis Treatment and Research
- RNA Interference and Gene Delivery
- Graphene and Nanomaterials Applications
- Prostate Cancer Treatment and Research
- Cancer Cells and Metastasis
- Ferroptosis and cancer prognosis
- biodegradable polymer synthesis and properties
- Cell Adhesion Molecules Research
- Craniofacial Disorders and Treatments
- Facial Trauma and Fracture Management
- Head and Neck Cancer Studies
- Cleft Lip and Palate Research
- Bioinformatics and Genomic Networks
- TGF-β signaling in diseases
- Polymer Surface Interaction Studies
- Electrospun Nanofibers in Biomedical Applications
- Salivary Gland Tumors Diagnosis and Treatment
- Salivary Gland Disorders and Functions
- Dendrimers and Hyperbranched Polymers
- Cancer, Hypoxia, and Metabolism
- Computational Drug Discovery Methods
- Wound Healing and Treatments
- Circular RNAs in diseases
- Cancer, Lipids, and Metabolism
Hebei Normal University
2024
Zhengzhou Central Hospital
2024
First Hospital of China Medical University
2004-2023
China Medical University
2004-2023
Dongguan People’s Hospital
2022
Southern Medical University
2022
Chinese Academy of Medical Sciences & Peking Union Medical College
2020
Peking Union Medical College Hospital
2020
Beijing Hospital
2020
Beijing University of Technology
2010-2017
We present a flexible and highly reproducible method using three-dimensional (3D) multicellular tumor spheroids to quantify chemotherapeutic nanoparticle penetration properties in vitro. generated HeLa cell-derived the liquid overlay method. To properly characterize spheroids, scanning electron microscopy, transmission multiphoton microscopy were used obtain high-resolution 3D images of spheroids. Next, pairing optical characterization techniques with flow cytometry, we quantitatively...
Abstract The use of biodegradable polymeric nanoparticles (NPs) for controlled drug delivery has shown significant therapeutic potential. Polyaspartic acid and polylactic are the most intensively studied polymers. In present study, novel amphiphilic co‐polymer NPs, poly( L ‐aspartic acid‐ co ‐lactic acid) with 1,2‐dipalmitoyl‐ sn ‐glycero‐3‐phosphoethanolamine (DPPE) (poly(AA‐co‐LA)/DPPE) is synthesized subsequently used to encapsulate an antitumor doxorubicin (DOX). formulation parameters...
Background The interpretation system for prostate MRI is largely based on qualitative image contrast of different tissue types. Therefore, a fast, standardized, and robust quantitative technique necessary. Synthetic capable quantifying multiple relaxation parameters, which might have potential applications in cancer (PCa). Purpose To investigate the use maps derived from synthetic diagnosis grading PCa. Study Type Prospective. Subjects In all, 94 men with pathologically confirmed PCa or...
ENKUR plays a crucial role in lung and colorectal cancers.Chemically synthesized cinobufotalin (CB) showed its significant anti-cancer effect nasopharyngeal carcinoma.However, the roles of CB along with their correlation are still unknown hepatocellular carcinoma (HCC).In this study, expression HCC tissue cells were detected.The relationship between clinical pathology was also assessed.In vivo vitro experiments conducted to explore effects molecular basis HCC.ENKUR correlated progression...
Intestinal dysbiosis plays a critical role in the pathogenesis of Parkinson's disease (PD), and probiotics have emerged as potential modulators central nervous system function through microbiota-gut-brain axis. This study aimed to elucidate anti-inflammatory effects underlying mechanisms probiotic strain Bifidobacterium animalis subsp. lactis NJ241 (NJ241) mouse model PD induced by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP). The impact was comprehensively assessed mice behavioral...
Osteosarcoma (OS) as an invasive and lethal malignancy showing a low 5-year survival rate requires novel therapeutic targets their suppressors to improve prevention treatment strategies. Our research served clarify the potential of ginger extract its underlying antineoplastic mechanisms in OS. In vitro studies were used detect anti-proliferation ability towards OS cells. Patient-derived xenograft (PDX) was performed confirm whether suppressed tumor growth. Cancer Heat Shock Protein (HSP)...
Keloids are benign dermal tumors characterized by fibroblastic proliferation and excessive accumulation of collagen. Oxymatrine (OMT) is an alkaloid extracted from the Chinese herb Sophora japonica with capacities anti-fibrosis.To evaluate effects OMT on collagen production to explore its mechanisms.OMT was applied human keloid fibroblasts in vitro. Collagen, transforming growth factor (TGF)-β1, TGF-β receptor, Smads were analyzed Western Blot, reverse transcription polymerase chain...
Cancer stem cells (CSCs) have been implicated in tumorigenesis and tumor recurrence metastasis are key therapeutic targets cancer treatment. MicroRNAs display potential by controlling the properties of CSCs; however, whether an association exists between miR-3682-3p CSCs is unknown.To investigate mechanism which promotes stemness maintenance hepatocellular carcinoma (HCC).MiR-3682-3p expression HCC cell lines 34 pairs normal specimens was assayed quantitative polymerase chain reaction. The...
Melanoma is an aggressive type of cutaneous malignancy. Transforming growth factor (TGF)‑β has been demonstrated to be important mediator tumor progression. However, the best our knowledge, systemic roles plasma TGF‑β and in situ have not investigated Han Chinese melanoma patients. The results present study that levels TGF‑β1, TGF‑β2 TGF‑β3 protein messenger RNA were significantly elevated tissues compared with those normal tissues. survival rates patients which triple‑positive (TGF‑β1+,...
Introduction Available patient-reported outcome (PRO) studies are mainly from single institution or of small sample size, and the variations across hospitals regions were not fully analysed. A multicentre, prospective, outcome-reconstruction oncoplastic cohort (PRO-ROC) will be planned to assess PROs Chinese patients with breast cancer who undergo reconstruction (BR) breast-conserving surgery (OBCS). Methods analysis The inclusion criteria female aged >18 years old BR OBCS. This include...
Abstract In this work, biodegradable amphiphilic copolymer nanoparticles based on dextran, polylactide (PLA), and 1,2‐dipalmitoyl‐ sn ‐glycero‐3‐phosphoethanolamine (DPPE) were prepared. To estimate their feasibility as drug carriers, an antitumor model drug, mitoxantrone (MTO), was successfully incorporated into the polymeric by double‐emulsion (DE) nanoprecipitation (NP) methods. The MTO‐loaded confirmed dynamic light scattering transmission electron microscopy. nanoparticle size, size...
There is strong evidence that angiopoietin-like peptide family involved in the invasiveness and metastasis of cancer. Angiopoietin-like protein 3 (ANGPTL3) proven to be angiogenesis tumor development. However, there no published data on role ANGPLT3 plays glioblastomas. The present study was conducted examine proteins expression its association with clinicopathological factors prognosis human Immunohistochemistry used evaluate ANGPTL3, EGFR VEGFR. We found 33 cases (57.9%) showed...