A5007615595- Supramolecular Self-Assembly in Materials
- Advanced biosensing and bioanalysis techniques
- Force Microscopy Techniques and Applications
- Lipid Membrane Structure and Behavior
- Chemical Synthesis and Analysis
- Advanced Nanomaterials in Catalysis
- Graphene and Nanomaterials Applications
- Anesthesia and Neurotoxicity Research
- Fullerene Chemistry and Applications
- Advanced Electron Microscopy Techniques and Applications
- Genomics and Phylogenetic Studies
- Molecular Sensors and Ion Detection
- Monoclonal and Polyclonal Antibodies Research
- Streptococcal Infections and Treatments
- Electrochemical Analysis and Applications
- Neuroinflammation and Neurodegeneration Mechanisms
- Fungal and yeast genetics research
- Essential Oils and Antimicrobial Activity
- Nanoparticles: synthesis and applications
- Diatoms and Algae Research
- China's Socioeconomic Reforms and Governance
- Natural product bioactivities and synthesis
- Neural dynamics and brain function
- Analytical chemistry methods development
- Bacteriophages and microbial interactions
Institute of Physics
2022-2025
Chinese Academy of Sciences
2008-2025
University of Chinese Academy of Sciences
2022-2025
Jianghan University
2023-2025
Center for Excellence in Brain Science and Intelligence Technology
2023-2025
National Laboratory for Superconductivity
2024
Anhui University
2024
Cornell University
2019-2022
Weill Cornell Medicine
2019-2022
Pacific Northwest National Laboratory
2016-2021
Elucidating the cellular organization of cerebral cortex is critical for understanding brain structure and function. Using large-scale single-nucleus RNA sequencing spatial transcriptomic analysis 143 macaque cortical regions, we obtained a comprehensive atlas 264 transcriptome-defined cell types mapped their distribution across entire cortex. We characterized layer region preferences glutamatergic, GABAergic, non-neuronal types, as well regional differences in cell-type composition...
Abstract An ability to develop sequence-defined synthetic polymers that both mimic lipid amphiphilicity for self-assembly of highly stable membrane-mimetic 2D nanomaterials and exhibit protein-like functionality would revolutionize the development biomimetic membranes. Here we report assembly lipid-like peptoids into stable, crystalline, free-standing self-repairing through a facile crystallization process. Both experimental molecular dynamics simulation results show assemble membranes an...
Phenol-like group functionalized graphene quantum dots that structurally mimic natural antioxidants are constructed as high-efficacy reactive oxygen species scavengers for acute kidney injury antioxidative therapy.
The folding of proteins into intricate three-dimensional structures to achieve biological functions, such as catalysis, is governed by both kinetic and thermodynamic controls. quest design artificial enzymes using minimalist peptides seeks emulate supramolecular existing in a catalytically active state. Drawing inspiration from the nuanced process protein folding, our study explores enzyme-like activity amphiphilic peptide nanosystems equilibrium non-equilibrium states, featuring formation...
Abstract Regulator of cell death-1 (RCD-1) governs the heteroallelic expression RCD-1-1 and RCD-1-2, a pair fungal gasdermin (GSDM)-like proteins, which prevent cytoplasmic mixing during allorecognition safeguard against mycoparasitism, genome exploitation, deleterious elements (e.g., senescence plasmids) by effecting form cytolytic death. However, underlying mechanisms RCD-1 acts on membrane remain elusive. Here, we demonstrate that binds acidic lipid membranes, forms pores, induces...
Claustrum orchestrates brain functions via its connections with numerous regions, but molecular and cellular organization remains unresolved. Single-nucleus RNA sequencing of 227,750 macaque claustral cells identified 48 transcriptome-defined cell types, most glutamatergic neurons similar to deep-layer insular neurons. Comparison macaque, marmoset, mouse transcriptomes revealed macaque-specific types. Retrograde tracer injections at 67 cortical 7 subcortical regions defined four distinct...
Publications concerning the mechanism of biological activity, especially immunological C60(OH)20 nanoparticles, are relatively limited. However, structure and characteristics this carbon allotrope have been widely investigated. In paper, we demonstrated that water-soluble nanoparticles an efficient anti-tumor activity in vivo, show specific immunomodulatory effects to immune cells, such as T cells macrophages, both vivo vitro. For example, can increase production T-helper cell type 1 (Th1)...
Abstract The use of biodegradable polymeric nanoparticles (NPs) for controlled drug delivery has shown significant therapeutic potential. Polyaspartic acid and polylactic are the most intensively studied polymers. In present study, novel amphiphilic co‐polymer NPs, poly( L ‐aspartic acid‐ co ‐lactic acid) with 1,2‐dipalmitoyl‐ sn ‐glycero‐3‐phosphoethanolamine (DPPE) (poly(AA‐co‐LA)/DPPE) is synthesized subsequently used to encapsulate an antitumor doxorubicin (DOX). formulation parameters...
Bactericidal perforin-2 assembles an inactivated pre-pore complex and undergoes a 180° reconfiguration for membrane attack.
The purpose of this study is to evaluate the overall toxicity nasal instilled nanoscale copper particles (23.5 nm) in mice. Pathological examination, target organs identification, and blood biochemical assay experimental mice were carried out comparison with micro-sized (17 microm). However, only high-dose group nanoparticles (40 mg/kg body weight for three times one week), retarded significant pathological changes observed. There hydropic degeneration around central vein spotty necrosis...
Due to their unique physical and chemical properties, 2D materials have attracted intense interest for applications in filtration, sensing, nanoelectronics, biomedical devices. Peptoids are a class of biomimetic sequence‐defined polymers which certain amphiphillic sequences self‐assemble into crystalline with properties that mimic those cell membranes. In this study the ability these membrane‐like self‐repair following damage on range substrates is explored. situ atomic force microscopy...
Abstract Septins are GTP-binding proteins involved in diverse cellular processes including division and membrane remodeling. form linear, palindromic heteromeric complexes that can assemble filaments higher-order structures. Structural studies revealed various septin architectures, but questions concerning assembly-dynamics -pathways persist. Here we used high-speed atomic force microscopy (HS-AFM) kinetic modeling which allowed us to determine filament assembly was a diffusion-driven...
High-bandwidth and long-range nanoprecision motion is crucially required by many advanced instruments robotic systems, which rely on the nanopositioners. However, traditional nanopositioners suffer from their fixed stiffness can only obtain performance, leading to narrow applications. Here, a novel nanopositioner called normal-stressed electromagnetic-driven stiffness-tunable (EDSTN) presented, consists of three parts: A electromagnetic actuator generate actuation force, high-stiffness...
Enzymatic suicide inactivation, a route of permanent enzyme inhibition, is the mechanism action for wide array pharmaceuticals. Here, we developed first nanosensor that selectively reports inactivation pathway an enzyme. The sensor based on modulation near-infrared fluorescence enzyme-bound carbon nanotube. responded to substrate-mediated tyrosinase via bathochromic shifting nanotube emission wavelength. Mechanistic investigations revealed singlet oxygen generated by induced response. We...
Abstract Perforin-2 (PFN2, MPEG1) is a pore-forming protein that acts as first line of defense in the mammalian immune system, rapidly killing engulfed microbes within phagolysosome macrophages. PFN2 self-assembles into hexadecameric pre-pore rings transition upon acidification pores damaging target cell membranes. Here, using high-speed atomic force microscopy (HS-AFM) imaging and line-scanning molecular dynamics simulation, we elucidate to pore pathways dynamics. Upon acidification,...
The potential of polyamidoamine (PAMAM) dendrimers as solubility enhancers and oral drug delivery system was well known. Herein, we investigated the possibility PAMAM for promoting bioavailability puerarin. In present study, effect with different generations (G1.5, G2, G2.5, G3) on puerarin evaluated at concentrations pH conditions. Further more, puerarin–G2 dendrimer complex conducted in vitro hemolytic toxicity studies pharmacokinetics rats. significantly higher presence full generation...
Contractile injection systems generate 500 pN forces for membrane puncture by a domino-like collapse of sheath subunits.