A5004662691- Ginseng Biological Effects and Applications
- Natural product bioactivities and synthesis
- Nanoplatforms for cancer theranostics
- Luminescence and Fluorescent Materials
- Supramolecular Chemistry and Complexes
- Hepatitis B Virus Studies
- Pharmacological Effects of Natural Compounds
- Metal-Organic Frameworks: Synthesis and Applications
- Photodynamic Therapy Research Studies
- Semiconductor materials and interfaces
- Boron Compounds in Chemistry
- Supramolecular Self-Assembly in Materials
- Molecular Sensors and Ion Detection
- Ionic liquids properties and applications
- Hepatitis C virus research
- Anesthesia and Sedative Agents
- Sulfur-Based Synthesis Techniques
- Advanced Algorithms and Applications
- Bone health and osteoporosis research
- Liver Disease Diagnosis and Treatment
- Immune Response and Inflammation
- Covalent Organic Framework Applications
- Advanced Materials Characterization Techniques
- Advancements in Battery Materials
- Cell death mechanisms and regulation
Fudan University
2014-2025
Shuguang Hospital
2025
Shanghai University of Traditional Chinese Medicine
2021-2025
Shanghai Jiao Tong University
2005-2024
Shanghai Ninth People's Hospital
2023-2024
Guangzhou Medical University
2021-2024
Guangzhou First People's Hospital
2024
Second Affiliated Hospital of Nanjing Medical University
2021-2024
Ruijin Hospital
2023
Zhejiang Taizhou Hospital
2022
We report a near-infrared emissive probe which can detect HOCl<italic>in vivo</italic>by both fluorescence imaging and the naked eye.
Heparins are widely used anticoagulants for surgical procedures and extracorporeal therapies. However, all of them have bleeding risks. Protamine sulfate, the only clinically approved antidote unfractionated heparin (UFH), has adverse effects. Moreover, protamine can partially neutralize low-molecular-weight heparins (LMWHs) is not effective fondaparinux. Here, an inclusion-sequestration strategy efficient neutralization by cationic porous supramolecular organic frameworks (SOFs) polymers...
Long-acting neuromuscular blocks followed by rapid reversal may provide prolonged surgeries with improved conditions omitting repetitive or continuous administration of the blocking agent (NMBA), eliminating residual block and minimizing postoperative recovery, which, however, is not clinically available. Here, we demonstrate that imidazolium-based macrocycles (IMCs) acyclic cucurbit[
The combination of ultralong-acting neuromuscular block and subsequent on-demand rapid reversal may provide prolonged surgeries with improved conditions by omitting continuous or repetitive blocker administration, enabling a more stable predictable hemodynamic profile eliminating residual block. For this target, we prepared 19 imidazolium-incorporated tetracationic macrocycles. In vivo studies rats revealed that one macrocycle (IMC-14) displays extremely high blocking activity. At the dose...
This study investigated the phytochemical profiles and bioactivities of two edible boletes from Southwestern China, Phlebopus portentosus Butyriboletus roseoflavus. A total 33 secondary metabolites, comprising 15 alkaloids, 4 pulvinic acid derivative pigments, 14 ergosterols, were isolated identified. To our best knowledge, boletesine (1), B (2), cis-xerocomic (16) previously undescribed compounds. The new structures established by extensive spectroscopic methods chemical calculations....
Abstract Introduction Factors implicated in influenza-mediated morbidity and mortality include robust cytokine production (cytokine storm), excessive inflammatory infiltrates, virus-induced tissue destruction. Tumor necrosis factor-alpha (TNF-α) is an important pro-inflammatory present during influenza infection, but it unclear whether direct inhibition of TNF-α can elicit protection against infection. Methods In this study, the commercially available inhibitor etanercept was used to inhibit...
A palladium-catalyzed direct C–H bond sulfonylation of indoles with the insertion sulfur dioxide is achieved through a three-component reaction 1-(pyridin-2-yl)indoles, DABCO·(SO2)2, and aryldiazonium tetrafluoroborates under mild conditions. Diverse 2-sulfonated are generated by using 10 mol % palladium(II) bromide as catalyst at room temperature. This synthetic approach efficient merging palladium catalysis via radical process. 2-Pyrimidinyl can be used directing group well for...
Four water-soluble hydrazone-based three-dimensional (3D) flexible organic frameworks FOF-1–4 have been synthesized from a semirigid tetracationic tetraaldehyde and four dihydrazides. 1H NMR spectroscopy indicated the quantitative formation of in D2O, while dynamic light scattering experiments revealed that, depending on concentration, these porous display hydrodynamic diameters ranging 50 to 120 nm. The porosity is confirmed by ethanol vapor adsorption solid samples as well high loading...
The development of a reversal agent that can rapidly reverse clinically used nondepolarizing neuromuscular blocking agents (NMBAs) has long been challenge. Here, we report the synthesis series highly water-soluble acyclic cucurbit[
Incorporating the amorphous drug in polymeric components has been demonstrated as a feasible approach to enhance bioavailability of poorly water-soluble drugs. The objective this study was investigate role polymers stability solid dispersion (ASD) by evaluating drug-polymer interaction, microenvironmental pH, and ASD. Carbamazepine (CBZ), Biopharmaceutics Classification System Class II compound, utilized model drug. Polyvinylpyrrolidone (PVP), poly(1-vinylpyrrolidone-co-vinyl acetate)...
Unfractionated heparin (UFH) and low-molecular-weight heparins (LMWHs) are widely applied for surgical procedures extracorporeal therapies, which, however, suffer bleeding risk. Protamine, the only clinically approved antidote, can completely neutralize UFH, but partially neutralizes LMWHs, also has a number of safety drawbacks. Here, we show that caltrop-like multicationic small molecules both UFH LMWHs. In vitro ex vivo assays with plasma whole blood in mice rats support lead compound is...
The ethanol extract of Geranium carolinianum L., a domestic plant grown in China, was subjected to sequential extractions with different organic solvents. extracts were assayed for anti-hepatitis B virus (HBV) activities. ethyl acetate fraction found contain the highest level anti-HBV activity. In order identify active ingredients, further fractionated by column chromatography. Seven compounds identified including ellagic acid, geraniin, quercitrin, hyperin, hirsutrin, quercetin, and...
Broad-spectrum agents for the reversal of residual curarization induced by neuromuscular blocking are great significance. Here, we report a highly water-soluble cucurbit[8]uril (CB[8]) derivative as broad-spectrum block agent both benzylisquinolinium and aminosteroid supramolecular sequestration strategy. The UV/Vis competition titration assays suggest high binding affinity CB[8] toward benzylisquinolinium-type cisatracurium besylate aminosteroid-type rocuronium, vecuronium, pancuronium, at...
The purification method for a novel ginsenoside-hydrolyzing β-glucosidase from Paecilomyces Bainier sp. 229 was successfully simplified by the application of microcrystalline cellulose (MCC) as chromatographic matrix. Only two steps, Q-Sepharose FF and MCC column in sequence, were required to purify enzyme apparent homogeneity. purified enzyme, with native molecular weight estimated be 305 KDa, composed three identical subunits approximately 102 KDa each. optimal activity observed at pH 3.5...
A new amphiphilic acyclic cucurbit[n]uril (CB[n]) is designed and synthesized. This CB[n] could encapsulate pharmaceutical drugs via a host–guest interaction. Self-assembly of this forms spherical nanoparticles with diameters 91 nm in water. The self-assembled are capable delivering doxorubicin high efficiency. Cell experiments show that the doxorubicin-loaded can improve cellular uptake cytotoxicity by using MCF-7/ADR cell line. A549 tumor-bearing mouse model shows help overcome multidrug...