A5102003506- Nanoplatforms for cancer theranostics
- Periodontal Regeneration and Treatments
- Oral microbiology and periodontitis research
- Dental Implant Techniques and Outcomes
- Oral and Maxillofacial Pathology
- Blood groups and transfusion
- Advanced Nanomaterials in Catalysis
- Oral and gingival health research
- Magnesium Alloys: Properties and Applications
- Photodynamic Therapy Research Studies
- Bone Tissue Engineering Materials
- Aluminum Alloys Composites Properties
- Erythrocyte Function and Pathophysiology
- Air Quality and Health Impacts
- Graphene and Nanomaterials Applications
- Corneal Surgery and Treatments
- Wound Healing and Treatments
- Dental Research and COVID-19
- Advanced biosensing and bioanalysis techniques
- Inflammatory Biomarkers in Disease Prognosis
- Climate Change and Health Impacts
- Dental Health and Care Utilization
- Platelet Disorders and Treatments
- Corrosion Behavior and Inhibition
- Neonatal Health and Biochemistry
Jilin University
2014-2024
Stomatology Hospital
2014-2024
Hebei University of Engineering
2024
Affiliated Zhongshan Hospital of Dalian University
2023
Chinese PLA General Hospital
2014-2021
University of California, Davis
2016-2020
Shandong University
2016-2020
Central Hospital of Zibo
2017-2019
University of Electronic Science and Technology of China
2012
Shanghai First Maternity and Infant Hospital
2007-2008
Abstract Macrophage polarization toward M1 phenotype (pro‐inflammation) is closely associated with the destructive phase of periodontal inflammation. Nanoceria verified to inhibit macrophages by favorable ability reactive oxygen species (ROS) scavenging. However, function nanoceria on macrophage M2 (anti‐inflammation) in reparative inflammation quite limited. In this work, introducing an antioxidant drug quercetin onto nano‐octahedral ceria, synergistic and intense regulation host immunity...
Numerous nanomedicines currently emerge to reduce the dramatic threat in antibiotics resistance for antibacterial application against severe bacterial infections, while it is restricted by over-reacted immune response pathogenic bacteria. Herein, enzymatic activity introduced into zeolitic imidazolate framework-8 (ZIF-8) achieve sterilization releasing Zn ions, as well inflammation regulation through variable valence of Mn ions that are uniformly doped its framework. Within this simple metal...
Abstract The hypoxic microenvironment, continuous oxygen consumption, and poor excitation light penetration depth during antimicrobial photodynamic therapy (aPDT) tremendously hinder the effects on bacterial inactivation. Herein, a smart nanocomposite with oxygen‐self‐generation is presented for enhanced selective antibacterial properties against anaerobe‐induced periodontal diseases. By encapsulating Fe 3 O 4 nanoparticles, Chlorin e6 Coumarin 6 in amphiphilic silane, combined (red...
Given the scarcity of novel antibiotics, eradication bacterial biofilm infections poses formidable challenges. Upon infection, host restricts Fe ions, which are crucial for growth and maintenance. Having coevolved with host, bacteria developed adaptive pathways like hemin-uptake system to avoid iron deficiency. Inspired by this, we propose a strategy, termed nutritional immunity therapy (INIT), utilizing Ga-CT@P nanocomposites constructed gallium, copper-doped tetrakis (4-carboxyphenyl)...
Antibacterial photodynamic therapy (aPDT) has emerged as an attractive treatment option for efficient removal of pathogenic bacteria. However, aPDT in deep tissue will encounter difficulties such limited light penetration depth, insufficient oxygen (O2) supply and inability to eliminate inflammation introduced by bacteria, which hinders its clinical application. Herein, the near infrared (NIR) strategy simultaneously generating O2 CO was developed based antibacterial mitigation infection...
Nowadays the multifunctional approaches to kill oral bacteria based on various nanocomposites have made great progress against periodontal infections, while material structure and its functional integration are still insufficient. Herein, this work proposes a therapeutic strategy of chemodynamical therapy (CDT) photothermal (PTT) in monocrystals effectively enhance synergistic treatment. The CuS/MnS@MnO2 consisting hexagonal CuS/MnS nano-twin-crystal with shell layer MnO2 is developed. In...
ABSTRACT Periodontitis involves hyperactivated stromal cells that recruit immune cells, exacerbating inflammation. This study presents an ATP-responsive metal–organic framework (Mg/Zn-MOF) designed for periodontitis treatment, utilizing ion interference to modulate responses and prevent tissue destruction. Addressing the challenges of synergistic effects targeted delivery faced by traditional immunomodulatory nanomaterials, Mg/Zn-MOF system is activated extracellular ATP—a pivotal molecule...
Concentrated growth factor (CGF) is a newly generated complex that comprises fibrin matrix incorporating factors and plasmatic leukocyte cytokines. It has been widely used in bone regenerative medicine. However, the effect of CGF on peripheral nerve regeneration had not previously investigated. The aim present study was to evaluate possibility using for by i) investigating proliferation Schwann cells (SCs) secretion neurotrophic (NGF) glial cell line‑derived (GDNF) vitro; ii) analyzing...
Abstract Given the scarcity of novel antibiotics, eradication bacterial biofilm infections poses formidable challenges. Upon infection, host restricts Fe ions, which are crucial for growth and maintenance. Having coevolved with host, bacteria developed adaptive pathways like hemin‐uptake system to avoid iron deficiency. Inspired by this, we propose a strategy, termed nutritional immunity therapy (INIT), utilizing Ga‐CT@P nanocomposites constructed gallium, copper‐doped tetrakis...
Photodynamic therapy (PDT) based periodontal disease treatment has received extensive attention. However, the deep tissue location of plaque makes conventional PDT encounter a bottleneck. Herein, upconversion fluorescent nanomaterial with near-infrared light excitation was introduced into disease, overcoming limited penetration depth visible in PDT. Photosensitizer Ce6 molecules were combined nanoparticles (UCNPs) NaYF4:Yb,Er novel strategy. The hydrophobic UCNPs modified amphiphilic silane,...
Abstract Background The existence of mesenchymal stem cells (MSCs) in Schneiderian membrane has not been determined. aim this study is to investigate whether there are MSCs membrane, and the effect platelet-rich fibrin (PRF) on osteogenic differentiation these new bone formation maxillary sinus after floor elevation. Methods derived (SM-MSCs) were isolated from rabbit sinus. Cells identified by flow cytometry multipotential differentiation. Real-time cell analysis assay, fluorescence...
Abstract This study evaluates the use of L-PRF as an autologous scaffold in nerve regeneration, and Schwann cells (SCs) proliferation secretion neurotrophic factors its anti-inflammatory effect on SC Porphyromonas Gingivalis-Lipopolysaccharide (PG-LPS)-induced inflammatory responses vitro . SEM was done to investigate various features L-PRF. L-PRF-extracts used release growth treatment SCs line. ELISA applied examine IGF-1. The proliferative assessed with CCK-8 assay. mRNA protein expression...