A5007286842- HER2/EGFR in Cancer Research
- Oral microbiology and periodontitis research
- Bone Tissue Engineering Materials
- Advanced Drug Delivery Systems
- Graphene and Nanomaterials Applications
- Nanoplatforms for cancer theranostics
- Monoclonal and Polyclonal Antibodies Research
- CAR-T cell therapy research
- Nanofabrication and Lithography Techniques
- biodegradable polymer synthesis and properties
- Antimicrobial Peptides and Activities
- Electrospun Nanofibers in Biomedical Applications
- Nanomaterials for catalytic reactions
- Neuropeptides and Animal Physiology
- Periodontal Regeneration and Treatments
- Adsorption and biosorption for pollutant removal
- Supramolecular Self-Assembly in Materials
- Cell Adhesion Molecules Research
- Cellular Mechanics and Interactions
- Anesthesia and Pain Management
- Radiopharmaceutical Chemistry and Applications
- Dental Implant Techniques and Outcomes
- Protease and Inhibitor Mechanisms
- Autopsy Techniques and Outcomes
- Chemokine receptors and signaling
Jilin University
2009-2025
University of Michigan
2021-2024
Zunyi Medical University
2021-2022
Weifang Chinese Medicine Hospital
2021
Affiliated Hospital of Youjiang Medical University for Nationalities
2021
Changchun Institute of Applied Chemistry
2018
Chinese Academy of Sciences
2018
Louisiana State University Health Sciences Center New Orleans
2017
Ochsner Medical Center
2017
Luoyang Central Hospital Affiliated to Zhengzhou University
2016
Antibody drug conjugates (ADCs) have made impressive strides in the clinic recent years with 11 Food and Drug Administration approvals, including 6 for treatment of patients solid tumors. Despite this success, development new agents remains challenging a high failure rate clinic. Here, we show that current approved ADCs tumors can all substantial efficacy some mouse models when administered at similar weight-based [milligrams per kilogram (mg/kg)] dosing mice is tolerated Mechanistically,...
Periodontitis is a common condition characterized by bacterial infection and the disruption of body's immune-inflammatory response, which causes damage to teeth supporting tissues eventually results in tooth loss. Current therapy involves systemic local administration antibiotics. However, existing treatments cannot exert effective, sustained release maintain an effective therapeutic concentration drug at lesion site. Hydrogels are used treat periodontitis due their low cytotoxicity,...
3D ordered silver nanoshells silica photonic crystal beads as a novel encoded surface enhanced Raman scattering substrate are proposed for the development of highly efficient multiplex bioassays.
Guided bone regeneration (GBR) is one such treatment that reconstructs neo-bone tissue by using a barrier membrane to prevent the invasion of soft and create space for guiding new growth into defect. Herein, we report novel functionally graded bilayer (FGBM) GBR application. To fabricate membrane, composites poly(lactic-co-glycolic acid) nano-hydroxyapatite were prepared phase inversion dense layer electrospinning another porous layer, their corresponding properties evaluated including...
Abstract Objective PE is a pregnancy‐specific syndrome that affects 3%–5% of pregnant women. It often presents as new‐onset hypertension and proteinuria during the third trimester. progresses rapidly may lead to serious complications, including death both mother fetus. In low‐income countries, one main causes maternal child mortality. While cause still debated, clinical pathological studies suggest placenta plays an important role in pathogenesis PE. Materials Methods this single‐cell...
Periodontal defects involve the damage and loss of periodontal tissue, primarily caused by periodontitis. This inflammatory disease, resulting from various factors, can lead to irreversible harm tissues supporting teeth if not treated effectively, potentially in tooth or loosening. Such outcomes significantly impact a patient’s facial appearance their ability eat speak. Current clinical treatments for periodontitis, including surgery, root planing, types curettage, as well local antibiotic...
Novel quantum-dot-tagged photonic crystal beads were fabricated for multiplex detection of tumor markers via self-assembly quantum dot-embedded polystyrene nanospheres into through a microfluidic device.
The Cr(<sc>vi</sc>) adsorption mechanism by CS/PEO/PT composite nanofibers includes electrostatic interaction, chelation, reduction and ion exchange.
The treatment of large-area bone defects remains a challenge; however, various strategies have been developed to improve the performances scaffolds in tissue engineering. In this study, poly(lactide-co-glycolide)/hydroxyapatite (PLGA/HA) scaffold was coated with Asp-Gly-Glu-Ala (DGEA)-incorporated collagen for repair rat skull defect. Our results indicated that mechanical strength and hydrophilicity PLGA/HA were clearly improved conducive cell adhesion proliferation. collagen-coated DGEA...
Part of differentiated thyroid cancer will relapse or develop into dedifferentiated after standard therapy, such as surgery radionuclide therapy. Sorafenib (SOR) is recommended for the treatment advanced radioiodine-refractory cancer. The monotherapy using SOR often hampered by its modest efficacy, serve systemic toxicity, and high occurrence drug resistance. In order to enhance antitumor effect reduce side effects, all-trans retinoic acid (ATRA), a differentiation-promoting drug, were...
Adrenomedullin (ADM) is a bioactive regulatory peptide that affects migration and proliferation of diverse cell types, including endothelial cells, smooth muscle osteoblast-like cells. This study investigated the effects sustained release ADM on modulation activity osteoblasts vascular cells in vitro . Chitosan microspheres (CMs) were developed for delivery. Poly(lactic-co-glycolic) acid nano-hydroxyapatite used to prepare scaffolds containing with ADM. The CMs showed rough surface...
With the increasing application of medical imaging contrast materials, contrast-induced nephropathy (CIN) has become third major cause iatrogenic renal insufficiency. CIN is defined as an absolute increase in serum creatinine levels at least 0.50 mg/dl or >25% from baseline after exposure to contrast. In this study, protective effects salvianolic acid B (Sal B) were detected human tubular epithelial cells (HK-2) exposed iopromide. The results showed that different concentrations Sal...