A5100441739- Peptidase Inhibition and Analysis
- Radiopharmaceutical Chemistry and Applications
- Prostate Cancer Treatment and Research
- Endometriosis Research and Treatment
- Medical Imaging Techniques and Applications
- Medical Imaging and Pathology Studies
- Science, Research, and Medicine
- Uterine Myomas and Treatments
- Prostate Cancer Diagnosis and Treatment
- Histiocytic Disorders and Treatments
- Lymphoma Diagnosis and Treatment
- Hematological disorders and diagnostics
- Sarcoma Diagnosis and Treatment
- Viral-associated cancers and disorders
- Cancer therapeutics and mechanisms
- Advanced SAR Imaging Techniques
- RNA Interference and Gene Delivery
- Advanced biosensing and bioanalysis techniques
- Endometrial and Cervical Cancer Treatments
- Protease and Inhibitor Mechanisms
- Lung Cancer Diagnosis and Treatment
- Intestinal and Peritoneal Adhesions
- Urologic and reproductive health conditions
- Radiomics and Machine Learning in Medical Imaging
- Cardiac tumors and thrombi
Chinese Academy of Medical Sciences & Peking Union Medical College
2015-2025
Affiliated Hospital of Southwest Medical University
2017-2024
University of Electronic Science and Technology of China
2011-2024
University of Guelph
2024
Fudan University
2011-2024
Shanghai Jiao Tong University
2019-2024
First Affiliated Hospital of Sichuan Medical University
2010-2024
Shihezi University
2024
China Geological Survey
2024
Woodlands Health Campus
2024
beta-amyloid plaques (Abeta plaques) in the brain, containing predominantly fibrillary Abeta peptide aggregates, represent a defining pathologic feature of Alzheimer disease (AD). Imaging agents targeting living human brain are potentially valuable as biomarkers pathogenesis processes AD. (E)-4-(2-(6-(2-(2-(2-(18)F-fluoroethoxy)ethoxy)ethoxy)pyridin-3-yl)vinyl)-N-methyl benzenamine ((18)F-AV-45) is such an agent currently phase III clinical studies for PET brain.In vitro binding (18)F-AV-45...
This report shows that a nanovector composed of peptide-based nanofibrous hydrogel can condense DNA to result in strong immune responses against HIV. strongly activate both humoral and cellular balanced level rarely reported previous studies, which is crucial for HIV prevention therapy. In addition, this good biosafety vitro vivo. Detailed characterizations show the structure critical dramatically improved compared existing materials. great potential efficacious vaccines be potentially used...
The development of multidrug resistance (MDR) to chemotherapy remains a major challenge in the treatment cancer. Numerous mechanisms have been recognized that cause MDR, but one most important is overexpression adenosine triphosphate (ATP)-binding cassette (ABC) transporters, through which efflux various anticancer drugs against their concentration gradients powered by ATP. In recent years, small molecular tyrosine kinase inhibitors (TKIs) developed for human cancers overexpressing epidermal...
Ideal tissue-engineering cartilage scaffolds should possess the same nanofibrous structure as microstructure of native well biological function provided by microenvironment for neocartilage regeneration. In present study, three-dimensional composite biomimetic with different concentration ratios electrospun gelatin-polycaprolactone (gelatin-PCL) nanofibers and decellularized extracellular matrix (DCECM) were fabricated. The microarchitecture served a skeleton excellent mechanical properties,...
Background The interpretation system for prostate MRI is largely based on qualitative image contrast of different tissue types. Therefore, a fast, standardized, and robust quantitative technique necessary. Synthetic capable quantifying multiple relaxation parameters, which might have potential applications in cancer (PCa). Purpose To investigate the use maps derived from synthetic diagnosis grading PCa. Study Type Prospective. Subjects In all, 94 men with pathologically confirmed PCa or...
Patients with glioblastoma have one of the lowest overall survival rates among patients cancer. Standard care for includes temozolomide and radiation therapy, yet 30% do not respond to these treatments nearly all tumors become resistant. Chlorpromazine is a United States Food Drug Administration-approved phenothiazine widely used as psychotropic in clinical practice. Recently, experimental evidence revealed anti-proliferative activity chlorpromazine against colon brain tumors. Here, we...
This study was designed to assess the diagnostic value of <sup>68</sup>Ga-NOTA-PRGD2 (NOTA-PRGD2 is NOTA-PEG4-E[c(RGDfK)]<sub>2</sub>) PET/CT in lung cancer. <b>Methods:</b> Ninety-one patients (48 men and 43 women; age, 22–82 y) with suspected lesions on CT were enrolled informed consent. Immediately after intravenous injection 117.7 ± 37.7 MBq <sup>68</sup>Ga-NOTA-PRGD2, 15 underwent dynamic whole-body scans for 1–2 h, remaining 76 at 30 10 min bolus injection. Each patient also standard...
Infected diabetic wound (DW) healing entails a series of temporally and spatially regulated stages including antibacterial responses, revascularization, collagen deposition, underscoring the need for controlled sequential delivery appropriate compounds when treating these wounds. Here, we designed multifunctional core–shell [email protected]/[email protected] nanofiber loaded with three bioactive agents, chitosan (CTS), copper (Cu), decellularized Wharton’s jelly matrix (DWJM). We used this...
Three editions of International Classification Headache Disorders (ICHD) diagnostic criteria for Tolosa-Hunt syndrome (THS) have been published in 1988, 2004 and 2013, ICHD-3 beta, there considerable changes [corrected]. The validity these new remains to be established.We retrospectively identified 77 patients with non-traumatic painful ophthalmoplegia (PO) admitted between 2003 2013. We reviewed patients' age at onset gender, time courses pain development cranial nerve palsy, the nerves...
Developing RNA‐interference‐based therapeutic approaches with efficient and targeted cytosolic delivery of small interfering RNA (siRNA) is remaining a critical challenge since two decades. Herein, multifunctional transferrin receptor (TfR)‐targeted siRNA system (Tf&INF7) designed based on complexes formed the cationic lipo‐oligoamino amide 454 , sequentially surface‐modified polyethylene glycol‐linked (Tf) for targeting endosomolytic peptide INF7 release siRNA. Effective Tf&INF7...
Soy isoflavones are natural tyrosine kinase inhibitors closely associated with decreased morbidity and mortality of various tumors. The activation kinases such as ERBB2 is the mechanism by which cholecystitis transforms into gallbladder cancer (GBC), therefore, it important to investigate relationship between long-term exposure soy occurrence progression GBC. This case-control study (n = 85 pairs) found that high level plasma isoflavone-genistein (GEN) was a lower risk (≥326.00 ng/mL...
Functional repair of articular cartilage defects is always a great challenge in joint surgery clinically. Tissue engineering strategies that combine autologous cell implantation with three-dimensional scaffolds have proven effective for repairing tissue. However, it faces the problem sources and scaffold materials. Autologous chondrocytes bone marrow are difficult to popularize clinically due limited donor low mononuclear (MNC) concentrations, respectively. The density gradient...
ABSTRACT Background [18F] AlF-NOTA-FAPI-04 is a novel positron emission tomography (PET) ligand, which specifically targets fibroblast activation protein (FAP) expression as FAP inhibitor (FAPI). We analysed the diagnostic value of PET/CT for non-invasive assessment kidney interstitial inflammation and fibrosis in different renal pathologies. Methods Twenty-six patients (14 males 12 females; mean age, 50.5 ± 16.5 years) with wide range diseases 10 (six four 55.4 8.6 without known evidence...
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Arterial stiffness is recognized as a new risk factor for stroke. However, the association between estimated pulse wave velocity (ePWV), well-established indirect measure of arterial and stroke among older adults, remains incompletely investigated. This study utilized data from 3 prospective, nationally representative cohorts: Health Retirement Study in United States, English Longitudinal Aging Kingdom, China China. ePWV was calculated based on age mean pressure. Cox proportional hazard...
Global climate change poses critical challenges to food security and market stability as extreme weather events&#160;become increasingly frequent severe. The combined effects of compound events global trade dynamics on security, however, remain insufficiently explored. Here, we employed a copula-based statistical approach, integrating international data estimate maize yield failures under drought heat (CDHEs) assess how dependence supply diversity impact such stressors.&#160;Our...