A5059060504- Advanced oxidation water treatment
- Advanced Photocatalysis Techniques
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Pancreatic and Hepatic Oncology Research
- GNSS positioning and interference
- Inertial Sensor and Navigation
- Geophysics and Gravity Measurements
- Astronomical Observations and Instrumentation
- Cancer, Lipids, and Metabolism
- Cancer-related molecular mechanisms research
- Water Treatment and Disinfection
- Gallbladder and Bile Duct Disorders
- Planetary Science and Exploration
- Cancer Mechanisms and Therapy
- SARS-CoV-2 and COVID-19 Research
- Electrochemical Analysis and Applications
- Advanced Computational Techniques and Applications
- Long-Term Effects of COVID-19
- Plasma Applications and Diagnostics
- Dermatologic Treatments and Research
- COVID-19 Clinical Research Studies
- Peptidase Inhibition and Analysis
- Gastric Cancer Management and Outcomes
- Ammonia Synthesis and Nitrogen Reduction
- Seismology and Earthquake Studies
Renji Hospital
2021-2025
Shanghai Jiao Tong University
2017-2025
Ruijin Hospital
2017-2025
Harbin Institute of Technology
2022-2024
Shanghai Cancer Institute
2021-2024
State Key Laboratory of Oncogene and Related Genes
2021-2023
XinHua Hospital
2019-2021
Dalian University of Technology
2021
Wuhan University
2011-2016
Xijing Hospital
2008
•Epithelial subtype 1, 2 and 3 were mainly found in the adenocarcinoma 4 was present adenosquamous carcinoma.•Tumors with ErbB pathway mutations harbored a larger population of 1 epithelial cells, Tregs, M2 macrophages.•Increased MDK these tumors interacted its receptor LRP1 to promote immunosuppressive macrophage differentiation.•Crosstalk between macrophage-secreted CXCL10 CXCR3 on Tregs induced GBC mutations. Background & AimsOur previous genomic whole-exome sequencing (WES) data...
The electrochemical oxidation process has the unique advantage of in-situ •OH generation for deep mineralization organic pollutants, which is expected to provide a solution globally decentralized wastewater treatment and reuse. However, it still great challenge develop low-cost anodes with ultrahigh yield low energy consumption. Here, stable mixed metal oxide (MMO) anode (Cu-Sb-SnO 2 ) developed by simple scalable preparation presents extremely high pollutants degradation efficiency...
Constructing effective cathode materials for simultaneously producing and activating H2O2 to achieve functional reduction of O2 •OH production is crucial the development a heterogeneous electro-Fenton process in wastewater treatment. In this study, active groups carbonaceous catalyst electrochemical have been tuned identified from molecular level. Proton amines pyrolysis temperature present significant influences on polymerization phenolic-formaldehyde resin, thereby altering structure,...
Soy isoflavones are natural tyrosine kinase inhibitors closely associated with decreased morbidity and mortality of various tumors. The activation kinases such as ERBB2 is the mechanism by which cholecystitis transforms into gallbladder cancer (GBC), therefore, it important to investigate relationship between long-term exposure soy occurrence progression GBC. This case-control study (n = 85 pairs) found that high level plasma isoflavone-genistein (GEN) was a lower risk (≥326.00 ng/mL...
Background and Aims: Nicotinamide N-methyltransferase (NNMT), an enzyme responsible for the methylation of nicotinamide, is involved in many metabolic pathways adipose tissue liver. However, role NNMT editing tumor immune microenvironment not well understood. Approach Results: Here, we identified that can promote IL6 granulocyte-macrophage colony-stimulating factor (GM-CSF) expression by decreasing tri-methyl-histone H3 levels on promoters CSF2 (encoding GM-CSF) CCAAT/Enhancer Binding...
Background Angiogenesis is a major promotor of tumor progression and metastasis in gastric adenocarcinoma (STAD). We aimed to develop novel lncRNA gene signature by identifying angiogenesis-related genes better predict prognosis STAD patients. Methods The expression profiles mRNA were collected from Cancer Genome Atlas (TCGA). Then, the “limma” package was used identify differentially expressed (DEGs). clustered consumusclusterplus. Pearson correlation coefficient further lncRNAs coexpressed...
Abstract Background Gallbladder cancer (GBC) is the most common type of biliary tract, and an association has been found between chronic calculous cholecystitis (CCC) increased incidence GBC mortality. An understanding relationship CCC its carcinogenesis may enable us to prevent cure GBC. In this study, we attempted explore changes in microbiome profile that take place during transition from mucosa malignant lesions. Results Seven paired human samples were provided by patients who had...
Rac GTPase activating protein 1 (RACGAP1) has been characterized in the pathogenesis and progression of several malignancies, however, little is known regarding its role development gallbladder cancer (GBC).This investigation seeks to describe RACGAP1 associated molecular mechanisms GBC.It was found that highly expressed human GBC tissues, which poorer overall survival (OS).Gene knockdown hindered tumor cell proliferation both vitro vivo.We further identified involved DNA repair through...
To investigate the prognostic significance of systemic immune-inflammation index (SII) in patients after radical cholecystectomy for gallbladder cancer (GBC) using overall survival (OS) as primary outcome measure.Based on data from a multi-institutional registry with GBC, significant factors were identified by multivariate Cox proportional hazards model. A novel staging system was established, visualized nomogram. The response to adjuvant chemotherapy compared between different subgroups...
Abstract Background The progression of gallbladder cancer (GBC) is accompanied by abnormal fatty acid β-oxidation (FAO) metabolism. Different types lipids perform various biological functions. This study aimed to determine the role acyl carnitines in molecular mechanisms GBC progression. Methods Distribution was described LC–MS-based lipidomics. Cellular localization, expression level and full-length lncBCL2L11 were detected using fluorescence situ hybridization (FISH) assays, subcellular...
The first-line chemotherapy regimen for advanced gallbladder cancer (GBC) is gemcitabine plus platinum (GP), despite its efficacy limited. current investigation a retrospective study to compare the safety and between modified FOLFIRINOX (mFOLFIRINOX) oxaliplatin (GEMOX) as unresectable locally or metastatic GBC.The data of patients with GBC, who were treated mFOLFIRINOX GEMOX therapy April 2014 2018 at Xinhua Hospital Affiliated Shanghai Jiaotong University School Medicine, retrieved. This...