A5100697838- Cholangiocarcinoma and Gallbladder Cancer Studies
- RNA modifications and cancer
- PI3K/AKT/mTOR signaling in cancer
- Cancer-related Molecular Pathways
- Ubiquitin and proteasome pathways
- Cancer, Hypoxia, and Metabolism
- Ferroptosis and cancer prognosis
- Cancer, Lipids, and Metabolism
- PARP inhibition in cancer therapy
- Pancreatic and Hepatic Oncology Research
- Histone Deacetylase Inhibitors Research
- Peptidase Inhibition and Analysis
- DNA Repair Mechanisms
- MicroRNA in disease regulation
- Pharmacological Effects of Natural Compounds
- Plant Physiology and Cultivation Studies
- Natural product bioactivities and synthesis
- Epigenetics and DNA Methylation
- Cancer-related molecular mechanisms research
- Protein Degradation and Inhibitors
- Sarcoma Diagnosis and Treatment
- Phytochemistry and Biological Activities
- Bioactive Compounds and Antitumor Agents
- Cancer Genomics and Diagnostics
- Cancer Mechanisms and Therapy
Capital University of Economics and Business
2025
Air Force Medical University
2020-2025
Jiangmen Central Hospital
2025
Northwestern Polytechnical University
2022-2024
Chinese Academy of Agricultural Sciences
2022-2024
Institute of Pomology
2022-2024
Ministry of Agriculture and Rural Affairs
2022-2024
Capital Medical University
2024
First Hospital of Jilin University
2024
Jilin University
2024
•Epithelial subtype 1, 2 and 3 were mainly found in the adenocarcinoma 4 was present adenosquamous carcinoma.•Tumors with ErbB pathway mutations harbored a larger population of 1 epithelial cells, Tregs, M2 macrophages.•Increased MDK these tumors interacted its receptor LRP1 to promote immunosuppressive macrophage differentiation.•Crosstalk between macrophage-secreted CXCL10 CXCR3 on Tregs induced GBC mutations. Background & AimsOur previous genomic whole-exome sequencing (WES) data...
Dietary methionine interventions are beneficial to apoptosis-inducing chemotherapy and radiotherapy for cancer, while their effects on ferroptosis-targeting therapy immunotherapy unknown. Here we show the length of time deprivation affects tumoral ferroptosis differently. Prolonged prevents glutathione (GSH) depletion from exceeding death threshold by blocking cation transport regulator homolog 1 (CHAC1) protein synthesis. Whereas, short-term starvation accelerates stimulating CHAC1...
Objectives Patients with gallbladder carcinoma (GBC) lack effective treatment methods largely due to the inadequacy of both molecular characterisation and potential therapeutic targets. We previously uncovered a spectrum genomic alterations identified recurrent mutations in ErbB pathway GBC. Here, we aimed study genes pathways larger cohort patients GBC investigate mechanisms clinical significance these mutations. Design performed whole-exome sequencing (WES) 157 Functional experiments were...
Abstract NOP 2/Sun domain family, member 2 ( NSUN 2) is a nuclear RNA methyl‐transferase catalyzing 5‐methylcytosine formation. Evidence shows that correlated with cell unlimited proliferation. However, its functional role in gallbladder carcinoma GBC ), which the most common biliary tract malignancy and has poor prognosis, remains to be determined. Here we found was highly expressed tissues as well lines. silencing repressed proliferation tumorigenesis both vitro vivo. Conversely,...
Apples are a major horticultural crop worldwide. Grafting techniques widely utilized in apple production to keep the varieties pure. Interstocks frequently used Northern China achieve intensive dwarfing cultivation. High-throughput sequencing was investigate differentially expressed genes phloem tissues of two different xenograft systems, M ('Gala'/'Mac 9'/
Abstract Poly(ADP-ribose) polymerase (PARP) inhibitors have demonstrated promising clinical activity in multiple cancers. However, resistance to PARP remains a substantial challenge. In the present study, we report that anaplastic lymphoma kinase (ALK) directly phosphorylates CDK9 at tyrosine-19 promote homologous recombination (HR) repair and inhibitor resistance. Phospho-CDK9-Tyr19 increases its nuclear localization stabilize positive transcriptional elongation factor b activate...
Curcumin is a yellow pigment isolated from Corcuma longan. This research investigates the improvement of curcumin on INS-1 cells with insulin resistance induced by high glucose. were treated glucose (30 mmol L(-1)) for 48 h. Subsequently, medium was replaced 24 effectively increased gene expression and stimulated secretion (GSIS) in dose-dependent manner. Furthermore, molecular mechanism curcumin-induced glucose-induced investigated this study. transporter 2 (GLUT2) phosphorylation receptor...
Gallbladder carcinoma (GBC) is the most common and aggressive cancer of biliary tract. Liensinine has been proved to have hypotensive effect. However, effect liensinine on GBC still unknown. The aim this study investigate mechanism in human cells. Cell viability assay colony formation were performed assess cell growth proliferation. Flow cytometry analysis was used cycle apoptosis vitro. Hoechst 33342 staining also evaluate apoptosis. Western blot determine expression proteins corresponding...
To explore the effect of resveratrol in premature senescence and reveal its anti-premature mechanisms through network pharmacology.In this study, H2O2-induced bone marrow mesenchymal stem cells (BMMSCs) model is applied. Cell counting kit-8 assay, β-galactosidase staining flow cytometry are conducted to detect proliferation, apoptosis BMMSCs. Bioinformatics analyses used screen validate molecular targets acting on senescence. Dual-luciferase reporter assay verify interaction between v-rel...
Abstract Background Osteosarcoma is the most common malignant tumor in bone and its prognosis has reached a plateau past few decades. Recently, metabolic reprogramming attracted increasing attention field of cancer research. In our previous study, P2RX7 been identified as an oncogene osteosarcoma. However, whether how promotes osteosarcoma growth metastasis through remains unexplored. Methods We used CRISPR/Cas9 genome editing technology to establish knockout cell lines. Transcriptomics...