A5100402287- Epigenetics and DNA Methylation
- Circular RNAs in diseases
- Single-cell and spatial transcriptomics
- Cancer-related gene regulation
- Genetic Associations and Epidemiology
- RNA modifications and cancer
- Genetic Syndromes and Imprinting
- Plant tissue culture and regeneration
- Gene expression and cancer classification
- Genomics and Rare Diseases
- Polymer crystallization and properties
- Genetic and phenotypic traits in livestock
- Polymer Nanocomposites and Properties
- Genomic variations and chromosomal abnormalities
- Genetic Mapping and Diversity in Plants and Animals
- IL-33, ST2, and ILC Pathways
- Prenatal Screening and Diagnostics
- Transgenic Plants and Applications
- Drug Transport and Resistance Mechanisms
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Congenital heart defects research
- Dysphagia Assessment and Management
- MicroRNA in disease regulation
- Cancer-related molecular mechanisms research
- Connexins and lens biology
Ningbo College of Health Sciences
2024-2025
Yale University
2020-2025
Shanghai Ocean University
2023-2025
State Key Laboratory on Integrated Optoelectronics
2024-2025
Jilin University
2024-2025
Xi'an University of Technology
2025
Shanghai Academy of Agricultural Sciences
2025
Beijing Obstetrics and Gynecology Hospital
2024
Capital Medical University
2017-2024
Shanghai Jiao Tong University
2024
After optimization using percolation theory, excellent absorbing properties (90% absorption) were achieved for Ni/C nanocomposites with advantages such as thin thickness (1.75 and 1.5 mm) light weight (25 30 wt%).
The ubiquitin carboxyl-terminal hydrolase L1 (UCHL1) is a regulating cellular levels, recently suggested as tumor suppressor. However, the role of UCHL1 in hepatocellular carcinoma (HCC) not clear. We investigated expression and DNA methylation primary HCC, liver metastases from digestive carcinomas, cancers. expressed all normal tissues immortalized epithelial cell lines, but was low or silenced 77% (10/13) HCC which well correlated with its promoter status. Methylation further detected 44%...
Lilium spp. is a bulb flower with worldwide distribution and unique underground organs. The lack of an efficient genetic transformation system for has been international obstacle. Because existing model plants bulbs, bulb-related gene function verification studies cannot be carried out in plants. Here, two stable systems based on somatic embryogenesis adventitious bud regeneration were established species. Transgenic T-DNA insertion lines confirmed by β-glucuronidase(GUS) assay, polymerase...
Foundation Models (FMs) have made significant strides in both industrial and scientific domains. In this paper, we evaluate the performance of FMs for single-cell sequencing data analysis through comprehensive experiments across eight downstream tasks pertinent to data. Overall, top include scGPT, Geneformer, CellPLM by considering model performances user accessibility among ten FMs. However, comparing these with task-specific methods, found that may not consistently excel than methods all...
The exploration of antibiotic resistance genes (ARGs) in drinking water reservoirs is an emerging field. Using a curated database, we enhanced the ARG detection and conducted comprehensive analysis using 2.2 Tb deep metagenomic sequencing data to determine distribution ARGs across 16 associated environments. Our findings reveal greater diversity sediments than water, underscoring importance extensive background surveys. Crucial carriers—specifically Acinetobacter, Pseudomonas, Mycobacterium...
Translational control is crucial in the regulation of gene expression and deregulation translation associated with a wide range cancers human diseases. Ribosome profiling technique that provides genome information mRNA based on deep sequencing ribosome protected fragments (RPF). RPFdb comprehensive resource for hosting, analyzing visualizing RPF data, available at www.rpfdb.org or http://sysbio.sysu.edu.cn/rpfdb/index.html. The current version database contains 777 samples from 82 studies 8...
Highlights•Tsc1-null late embryonic RGCs generate cytomegalic pyramidal neurons (CPNs)•CPNs are synaptically hyperexcitable and susceptible to seizure-like activities•Enhanced synaptic excitation in CPNs contributes epileptogenesis•Astrocyte gliosis evolves secondary recurrent seizuresSummaryTuberous sclerosis complex (TSC) is a developmental disorder associated with epilepsy, autism, cognitive impairment. Despite inactivating mutations the TSC1 or TSC2 genes hyperactive mechanistic target...
Brain anatomy plays a key role in complex behaviors and mental disorders that are sexually divergent. While our understanding of the sex differences brain remains relatively limited, particularly underlying genetic molecular mechanisms contribute to these differences. We performed largest study volumes (N = 33,208) by examining both raw after controlling whole volumes. Genetic correlation analysis revealed only left amygdala. compared transcriptome between males females using data from GTEx...
Diamond‐based subwavelength antireflective microstructures are corrosion resistant, impact and possess high transmittance, thereby presenting broad application prospects in special optical windows. Nevertheless, fabricating uniform highly transmissive on diamond surfaces poses a significant challenge. The hard brittle properties of result large number chips particles, adhering to the during processing, which subsequently impacts subsequent processing. Herein, laser cleaning‐assisted...
Fusarium fujikuroi is the primary causal agent of rice bakanae disease, which can lead to substantial yield losses. Developing a rapid, highly specific, and accurate method for detecting F. crucial effective surveillance, prevention, control disease. In this study, novel detection assay, RPA-Cas12a-F, was developed by integrating recombinase polymerase amplification (RPA) Cas12a fujikuroi. This assay demonstrated limit (LOD) 1 copy/μL reference plasmid or 0.1 fg/μL genomic DNA (gDNA)....
The impact of oropharyngeal dysphagia (OD) on older adults is recognized in Western countries but has not received sufficient attention China. handicap index (DHI) scale an OD quality-of-life evaluation instrument. This study evaluated the psychometric properties Chinese version DHI adults. A total 600 were recruited from five nursing homes one city to complete 25-item scale. reliability and validity evaluated: internal consistency was investigated using Cronbach's alpha; test–retest...
Azobenzene mesogen, as a typical photo-responsive material, has potential possibility in the field of soft robots based on its trans-cis isomerization. The alignment azobenzene mesogen polymer network...
Identifying genes associated with rare diseases remains challenging due to the scarcity of patients and limited statistical power traditional association methods. Here, we introduce PERADIGM (Phenotype Embedding Similarity-based Rare Disease Gene Mapping), a novel framework that leverages natural language processing techniques integrate comprehensive phenotype information from electronic health records for disease gene discovery. employs an embedding model capture relationships between...
Abstract Purpose: CMTM5 (CKLF-like MARVEL transmembrane domain containing member 5) is located at 14q11.2, a locus associated with multiple cancers. It has six RNA splicing variants CMTM5-v1 as the major one. We explored its expression pattern in normal tissues and tumor cell lines, well functions carcinoma cells. Experimental Design: evaluated by semiquantitative reverse transcription-PCR (RT-PCR) lines of cervical, breast, nasopharyngeal, lung, hepatocellular, esophageal, gastric, colon,...
Epigenetic silencing of tumour suppressor genes (TSG) inactivates TSG functions. Previously, we identified PCDH10 as a methylated in carcinomas. Here, detected its frequent and methylation lymphoma cell lines including 100% Burkitt, diffuse large B cell, 86% Hodgkin, nasal natural killer/T-cell 1/3 leukaemia lines, primary tumours but not normal peripheral blood mononuclear cells or lymph nodes. could be reversed by demethylation with 5-aza-2'-deoxycytidine. Methylation was further 14%...
Background:The ability of nanomaterials to induce osteogenic differentiation is limited, which seriously imped the repair craniomaxillofacial bone defect.Magnetic graphene oxide (MGO) nanocomposites with excellent physicochemical properties have great potential in tissue engineering.In this study, we aim explore defect repairment effect MGO and its underlying mechanism.Methods: The biocompatibility was verified by CCK8, live/dead staining cytoskeleton staining.The function induced BMSCs...