After an osteosarcoma resection, the risks of cancer recurrence, postoperative infection, and large bone loss still threaten patients' health. Conventional treatment relies on implanting orthopedic materials to fill defects after surgery, but it has no ability destroying residual tumor cells preventing bacterial invasion. To tackle this challenge, here, we develop a novel multifunctional implant (SP@MX/GelMA) that mainly consists MXene nanosheets, gelatin methacrylate (GelMA) hydrogels,...

Abstract Pathogenic infection inevitably provokes chronic inflammation and stalls the normal orchestrated course of wound‐healing cascades. However, current antibacterial therapies focus on inherent bactericidal functions biomaterials. To take full advantage microenvironment (IME) peculiarities, an IME‐activated nanocatalytic membrane consisting electrospun poly (lactic‐co‐glycolic acid) (PLGA) scaffolds, MXene/Ag 2 S bio‐heterojunctions (MX/AS bio‐HJs), lactate oxidase (LOx) for cutaneous...

Wound healing is a highly orchestrated process involving variety of cells, including immune cells. Developing immunomodulatory biomaterials for regenerative engineering applications, such as bone regeneration, an appealing strategy. Herein, inspired by the effects gastrodin (a bioactive component in traditional Chinese herbal medicine), series new gastrodin-comprising biodegradable polyurethane (gastrodin-PU) and nano-hydroxyapatite (n-HA) (gastrodin-PU/n-HA) composites were developed. RAW...

Abstract Nanomaterial‐mediated ferroptosis has garnered considerable interest in the antibacterial field, as it invokes disequilibrium of ion homeostasis and boosts lipid peroxidation extra‐ intracellular bacteria. However, current ferroptosis‐associated strategies indiscriminately pose damage to healthy cells, ultimately compromising their biocompatibility. To address this daunting issue, work designed a precise bio‐heterojunction (F‐bio‐HJ) consisting Fe 2 O 3 , Ti C ‐MXene, glucose...

Abstract Intractable infected microenvironments caused by drug‐resistant bacteria stalls the normal course of wound healing. Sono‐piezodynamic therapy (SPT) is harnessed to combat pathogenic bacteria, but superabundant reactive oxygen species (ROS) generated during SPT inevitably provoke severe inflammatory response, hindering tissue regeneration. Consequently, an intelligent nanocatalytic membrane composed poly(lactic‐co‐glycolic acid) (PLGA) and black phosphorus /V 2 C MXene...

The compact three-dimensional (3D) structure of extracellular polymeric substances (EPS) within biofilms significantly hinders the penetration antimicrobial agents, making biofilm eradication challenging and resulting in persistent biofilm-associated infections. To address this challenge, a solution is proposed: probiotic bio-heterojunction (P-bioHJ) combining Lactobacillus rhamnosus with MXene (Ti

Nanohydroxyapatite (HA) synthesized by biomimetic strategy is a promising nanomaterial as bone substitute due to its physicochemical features similar those of natural nanocrystal in tissue. Inspired mussel adhesive chemistry, novel nano-HA was our work employing polydopamine (pDA) template under weak alkaline condition. Subsequently, the as-prepared pDA-templated HA (tHA) introduced into polycaprolactone (PCL) matrix via coelectrospinning, and bioactive tHA/PCL composite nanofiber scaffold...

Chemically linked double network (DN) hydrogels display extraordinary mechanical attributes but mostly suffer from poor self-healing property and unsatisfactory biocompatibility due to the irreversible breaks in their chemical-linked networks use of toxic chemical cross-linking agents. To address these limitations, we developed a novel κ-carrageenan/polyacrylamide (KC/PAM) DN hydrogel through dual physical-cross-linking strategy, with ductile, hydrophobically associated PAM being first...

Abstract: As United States Food and Drug Administration-approved implantable material, carbon fiber-reinforced polyetheretherketone (CFRPEEK) possesses an adjustable elastic modulus similar to cortical bone is a prime candidate replace surgical metallic implants. The bioinertness inferior osteogenic properties of CFRPEEK, however, limit its clinical application as orthopedic/dental In this study, CFRPEEK–nanohydroxyapatite ternary composites (PEEK/n-HA/CF) with variable surface roughness...

Implant-associated infections, which are normally induced by microbial adhesion and subsequent biofilm formation, a major cause of morbidity mortality. Therefore, practical approaches to prevent implant-associated infections in great demand. Inspired adhesive proteins mussels, here we have developed novel antibiotic-decorated titanium (Ti) material with enhanced antibacterial activity. In this study, Ti substrate was coated one-step pH-induced polymerization dopamine followed immobilization...

Polydopamine (PDA) coating provides a promising approach for immobilization of biomolecules onto almost all kinds solid substrates. However, the deposition kinetics PDA as function temperature and reaction method is not well elucidated. Since dopamine self-polymerization usually takes long time, therefore, rapid-formation film becomes imperative surface modification biomaterials medical devices. In present study, practical preparation rapidly-deposited was developed using uniquely designed...

Abstract Due to its similar elastic modulus of human bones, polyetheretherketone (PEEK) has been considered as an excellent cytocompatible material. However, the bioinertness, poor osteoconduction, and weak antibacterial activity PEEK limit wide applications in clinics. In this study, a facile strategy is developed prepare graphene oxide (GO) modified sulfonated (SPEEK) (GO‐SPEEK) through simple dip‐coating method. After detailed characterization, it found that GO closely deposits on surface...

As a chronic metabolic disease, diabetes mellitus (DM) creates hyperglycemic micromilieu around implants, resulting inthe high complication and failure rate of implantation because mitochondrial dysfunction in hyperglycemia. To address the daunting issue, authors innovatively devised developed mitochondria-targeted orthopedic implants consisted nutrient element coatings polyetheretherketone (PEEK). Dual elements, modality ZnO Sr(OH)2 , are assembled onto sulfonated PEEK surface...

A multifunctional two-dimensional nanocoating consists of graphene oxide nanosheets, polydopamine nanofilm, and oligopeptide constructed on porous sulfonated polyetheretherketone for the purpose bone infection treatment.

Abstract Infection and malignant tumors are the most common diseases in people's daily life, which seriously threaten human health. Because of frequent extensive administration antibiotics chemodrugs, prevalence multidrug‐resistant bacteria tumor cells makes conventional therapies less effective even invalid. To overcome repugnant dilemma, herein authors devise develop a hollow Cu 2− X S nano‐homojunction (nano‐HJ) platform for eradication both upon tissue‐penetrable near‐infrared (NIR)...

Biomaterial-associated infection (BAI) is a serious threat to patients' health. In general, bacteriostatic agents are loaded on the surface of biomaterials eliminate BAI; however, excessive usage these leads emergence drug-resistant bacteria and inadequacy tissue repair. To address this issue, here, we create photoresponsive osteopromotive coating that consists graphene oxide (GO) nanosheets, polydopamine (pDA) nanolayers, adiponectin (APN) protein bioinert sulfonated poly(etheretherketone)...