A5076697602- Cancer-related molecular mechanisms research
- MicroRNA in disease regulation
- Circular RNAs in diseases
- RNA modifications and cancer
- Extracellular vesicles in disease
- Oral microbiology and periodontitis research
- RNA Research and Splicing
- Bone Tissue Engineering Materials
- Pacific and Southeast Asian Studies
- Autophagy in Disease and Therapy
- dental development and anomalies
- Archaeology and ancient environmental studies
- GABA and Rice Research
- Bone and Dental Protein Studies
- Inflammasome and immune disorders
- Pharmacogenetics and Drug Metabolism
- Orthodontics and Dentofacial Orthopedics
- Bone Metabolism and Diseases
- Mesenchymal stem cell research
- Oral and Maxillofacial Pathology
- S100 Proteins and Annexins
- RNA Interference and Gene Delivery
- Hippo pathway signaling and YAP/TAZ
- Immune Response and Inflammation
- Oral and gingival health research
Peking University
2016-2025
Stomatology Hospital
2013-2025
Qingdao University of Technology
2025
National Clinical Research Center for Digestive Diseases
2022-2024
Henan Provincial Institute of Cultural Heritage and Archaeology
2009-2024
National Clinical Research
2022
King Center
2022
Center for Life Sciences
2022
King University
2018-2022
Peking University People's Hospital
2021
The process of rice domestication occurred in the Lower Yangtze region Zhejiang, China, between 6900 and 6600 years ago. Archaeobotanical evidence from site Tianluoshan shows that proportion nonshattering domesticated (Oryza sativa) spikelet bases increased over this period 27% to 39%. Over same period, remains 8% 24% all plant remains, which suggests an consumption relative wild gathered foods. In addition, assemblage annual grasses, sedges, other herbaceous plants indicates presence arable...
Abstract Long noncoding RNAs (lncRNAs) are emerging as important regulatory molecules at the transcriptional and post-transcriptional levels may play essential roles in differentiation of human bone marrow mesenchymal stem cell (hMSC). However, their functions remain unclear. Here, we showed that lncRNA H19 was significantly upregulated after induction osteoblast differentiation. Overexpression promoted osteogenic hMSCs vitro enhanced heterotopic formation vivo, whereas knockdown inhibited...
Periodontal ligament stem cells (PDLSCs) are considered as candidate for the regeneration of periodontal and alveolar bone tissues. Antisense to cerebellar degeneration-related protein 1 transcript (CDR1as), which is a newly discovered circular RNA (circRNA), has been reported act an miR-7 sponge be involved in many biological processes. Here, we investigated potential roles CDR1as osteogenic differentiation PDLSCs. The expression pattern PDLSCs during osteogenesis was detected by...
Abstract: As United States Food and Drug Administration-approved implantable material, carbon fiber-reinforced polyetheretherketone (CFRPEEK) possesses an adjustable elastic modulus similar to cortical bone is a prime candidate replace surgical metallic implants. The bioinertness inferior osteogenic properties of CFRPEEK, however, limit its clinical application as orthopedic/dental In this study, CFRPEEK–nanohydroxyapatite ternary composites (PEEK/n-HA/CF) with variable surface roughness...
Abstract Bone marrow mesenchymal stem cells (BMSCs) exhibit an increased propensity toward adipocyte differentiation accompanied by a reduction in osteogenesis osteoporotic bone marrow. However, limited knowledge is available concerning the role of long non-coding RNAs (lncRNAs) BMSCs into adipocytes. In this study, we demonstrated that lncRNA H19 and microRNA-675 ( miR-675 ) derived from were significantly downregulated differentiating Overexpression inhibited adipogenesis, while knockdown...
Abstract Osteogenic differentiation and bone formation is suppressed under condition of inflammation induced by proinflammation cytokines. A number studies indicate miRNAs play a significant role in tumor necrosis factor-α-induced inhibition formation, but whether long non-coding RNAs are also involved this process remains unknown. In study, we evaluated the MIR31HG osteogenesis human adipose-derived stem cells (hASCs) vitro vivo. The results suggested that knockdown not only significantly...
Periodontitis is characterized by periodontal pocket formation, loss of attachment, and alveolar bone resorption. Both innate adaptive immunity are involved in the pathogenesis this oral chronic inflammatory disease. Accumulating evidence indicates a critical role leptin diseases. However, mechanism which promotes periodontitis remains unclear. In present study, we observed an elevated expression serum mice compared to that healthy controls. There was higher extent M1 phenotype macrophage...
Background: The present study aims to investigate the distinct expression pattern of circular RNAs (circRNAs) in periodontal ligament stem cells (PDLSCs) during osteogenesis. Methods: PDLSCs were isolated and cultured osteogenic medium. Total RNA was extracted from at day 0 (D0), 3 (D3), 7 (D7), 14 (D14) submitted RNA‐sequencing detect profiles circRNAs, messenger (mRNAs), microRNAs (miRNAs). Real‐time quantitative reverse‐transcription polymerase chain reaction (qRT‐PCR) performed validate...
Adipogenesis plays an important role in the regulation of whole-body energy homeostasis and is inextricably related to obesity. Several studies have highlighted relevance microRNAs adipocyte differentiation, but contributions long non-coding RNAs (lncRNAs) are still largely uncharacterized. Here, we determined that lncRNA MIR31HG lineage commitment. We demonstrated knockdown inhibited whereas overexpression promoted adipogenesis vitro vivo. Furthermore, inhibition reduced enrichment active...
MicroRNA plays an important role in bone tissue engineering; however, its and function osteogenic differentiation warrant further investigation. In this study, we demonstrated that miR-375 was upregulated during the of human adipose-derived mesenchymal stem cells (hASCs). Overexpression significantly enhanced hASCs osteogenesis both vitro vivo, while knockdown inhibited hASCs. Mechanistically, microarray analysis revealed DEPTOR as a target Knockdown accelerated by inhibiting AKT signaling,...
Periodontal ligament stromal cells (PDLSCs) are ideal cell sources for periodontal tissue repair and regeneration, but little is known about what determines their osteogenic capacity. Long non-coding RNAs (lncRNAs) important regulatory molecules at both transcriptional post-transcriptional levels. However, roles in the differentiation of PDLSCs still largely unknown. The expression lncRNA Fer-1-like family member 4 (FER1L4) during was detected by quantitative reverse transcription polymerase...
Abstract Osteoporosis is a prevalent metabolic bone disease characterized by low mineral density and degenerative disorders of tissues. Previous studies showed the abnormal osteogenic differentiation endogenous marrow mesenchymal stem cells (BMSCs) contributes to development osteoporosis. However, underlying mechanisms which BMSCs undergo remain largely unexplored. Recently, long non-coding RNAs have been discovered play important roles in regulating BMSC osteogenesis. In this study, we...
Abstract Objective To assess the tooth movement trends during three stages of maxillary dentition distalization with clear aligners (CA) and to compare efficacy different mini‐screw anchorage systems. Materials Methods Three‐dimensional (3D) finite element models systems (A, control group; B, buccal C, palatal group) were established. Three simulating CA included molar (stage 1), premolar 2) anterior teeth retraction 3). Therefore, a total nine constructed analyse 3D displacement process....
Background miR-34a is an important tumor suppressor gene in various cancer types. But little known about the dysregulation of tongue squamous cell carcinoma (TSCC). In this study, we investigate expression and potential role TSCC. Methods We evaluated its relationship with clinicopathological characters 75 pairs TSCC samples, confirmed for predicting lymph node metastases from a further 15 paraffin-embedded specimens stringent recruitment criteria using quantitative reverse transcription...
MiR-34a was demonstrated to be upregulated during the osteogenic differentiation of human adipose-derived stem cells (hASCs). Overexpression miR-34a significantly increased alkaline phosphatase activity, mineralization capacity, and expression osteogenesis-associated genes in hASCs vitro. Enhanced heterotopic bone formation vivo also observed upon overexpression hASCs. Mechanistic investigations revealed that inhibited retinoblastoma binding protein 2 (RBP2) reduced luciferase activity...
The mammalian target of rapamycin (mTOR) pathway plays a significant role in osteogenic differentiation and bone maintenance. As the only known endogenous inhibitor mTOR function, DEP domain containing interacting protein (DEPTOR) is potentially involved stem cell differentiation, although pathophysiological significance its molecular mechanisms remain unclear. present study aimed to elucidate effects DEPTOR on progress osteoporosis investigate underlying regulation. An ovariectomy mouse...
Abstract Recently, long non‐coding RNAs (lncRNAs) have emerged as critical players in gene regulation for multiple biological processes. However, their roles and functions human adipose‐derived stem cells (hASCs) differentiation remain unclear. In the present study, we investigated role of lncRNA myocardial infarction‐associated transcript ( MIAT ) osteogenic hASCs. We found that expression was downregulated a time‐dependent manner during hASCs osteoinduction. knockdown promoted both vitro...