A5109900770- Dental materials and restorations
- Bone Tissue Engineering Materials
- Mesenchymal stem cell research
- Dental Research and COVID-19
- Dental Implant Techniques and Outcomes
- Bone Metabolism and Diseases
- Geological formations and processes
- Epigenetics and DNA Methylation
- Orthodontics and Dentofacial Orthopedics
- Nanoplatforms for cancer theranostics
- Dental Radiography and Imaging
- Ubiquitin and proteasome pathways
- Geology and Paleoclimatology Research
- MicroRNA in disease regulation
- Graphene and Nanomaterials Applications
- Magnesium Alloys: Properties and Applications
- NF-κB Signaling Pathways
- Dental Education, Practice, Research
- Additive Manufacturing and 3D Printing Technologies
- Tissue Engineering and Regenerative Medicine
- Cancer-related gene regulation
- Autophagy in Disease and Therapy
- Extracellular vesicles in disease
- Digital Imaging in Medicine
- Histone Deacetylase Inhibitors Research
Peking University
2015-2025
Shanghai Medical College of Fudan University
2025
Zhongshan Hospital
2024-2025
Fudan University
2024-2025
Changzhou University
2024-2025
Stomatology Hospital
2015-2024
National Clinical Research
2018-2024
Digital China Health (China)
2024
The First Affiliated Hospital, Sun Yat-sen University
2024
Sun Yat-sen University
2024
Aging impairs tendon stem/progenitor cell function and homeostasis, however, effective treatments for aging-induced diseases are lacking. Exosomes naturally derived nanoparticles that contain bioactive molecules, therefore, have attracted great interest in tissue engineering regenerative medicine. In this study, it is shown young exosomes secreted by stem cells from human exfoliated deciduous teeth (SHED-Exos) possess abundant anti-aging signals. These bio-nanoparticles can alleviate the...
Herein, we report a facile fabrication of polymer (azobenzene and α-cyclodextrin-functionalized hyaluronic acid) gold nanobipyramids (AuNBs) conjugated mesoporous silica nanoparticles (MSNs) to be used as an injectable drug delivery system for sustained cancer treatment. Because the specific affinity between acid (HA) on MSNs CD44 antigen overexpressed tumor cells, can selectively attach cells. The nanocomposite material then exploits thermoresponsive interactions α-cyclodextrin azobenzene,...
In addition to T cells' roles in immune response and autoimmune diseases, certain types of cells, called regulatory cells (Tregs), play important microenvironment modulation for resolution tissue regeneration. However, there are currently few options available other than introducing more Tregs or immunosuppressive drugs locally enrich Tregs. Herein, poly(l-lactic acid) (PLLA) nanofibrous spongy microspheres (NF-SMS), PLLA/polyethylene glycol (PEG) co-functionalized mesoporous silica...
Macrophages play a crucial role in inflammatory-mediated bone loss. Orthodontic tooth movement (OTM) is associated with inflammatory remodeling. However, whether and how macrophages contribute to mechanical force-induced OTM remains unknown. In this study, we hypothesized that polarization of M1-like may the OTM. nickel-titanium springs were applied upper first molars rats or mice induce The distance gradually increased after force was for 5 10 d. macrophage expression M1 cytokine tumor...
Mesoporous silica nanocarriers with pH-switchable antifouling zwitterionic surface, enzyme responsive drug release properties and blue fluorescence are reported. Prolonged circulation in the blood system zero premature as well efficient cellular uptake intracellular tumor tissue achieved.
Human mesenchymal stem cells (MSCs) are multipotent progenitor that can differentiate into osteoblasts, chondrocytes, and adipocytes. The importance of epigenetic regulation for osteogenic differentiation MSCs is widely accepted. However, the molecular mechanisms poorly understood. Here, we show histone H3K9 acetyltransferase PCAF plays a critical role in MSCs. Knockdown significantly reduced bone formation both vitro vivo. Mechanistically, controls BMP signaling genes expression by...
The objective of this study was to determine the effect two plasma surface treatments on biologic responses PEEK medical implants manufactured by fused filament fabrication (FFF) 3D printing technology.This created standard samples using an FFF printer. After fabrication, half were polished simulate a smooth surface. Then, argon (Ar) or oxygen (O2) used modify bioactivity printed and samples. Scanning electron microscopy (SEM) profilometer microstructure roughness sample surfaces....
Polyetheretherketone (PEEK), a biomaterial with appropriate bone-like mechanical properties and excellent biocompatibility, is widely applied in cranio-maxillofacial dental applications. However, the lack of antibacterial effect an essential drawback PEEK material might lead to infection osseointegration issues. This study aims apply natural agent, totarol coating onto 3D printed surface find optimized concentration balanced cytocompatibility, osteogenesis, capability.
MiR-34a was demonstrated to be upregulated during the osteogenic differentiation of human adipose-derived stem cells (hASCs). Overexpression miR-34a significantly increased alkaline phosphatase activity, mineralization capacity, and expression osteogenesis-associated genes in hASCs vitro. Enhanced heterotopic bone formation vivo also observed upon overexpression hASCs. Mechanistic investigations revealed that inhibited retinoblastoma binding protein 2 (RBP2) reduced luciferase activity...
Abstract Recently, long non‐coding RNAs (lncRNAs) have emerged as critical players in gene regulation for multiple biological processes. However, their roles and functions human adipose‐derived stem cells (hASCs) differentiation remain unclear. In the present study, we investigated role of lncRNA myocardial infarction‐associated transcript ( MIAT ) osteogenic hASCs. We found that expression was downregulated a time‐dependent manner during hASCs osteoinduction. knockdown promoted both vitro...
ABSTRACT As the most well-studied histone acetyltransferase (HAT) in yeast and mammals, general control nonderepressible 5 (GCN5) was documented to play essential roles various developmental processes. However, little is known about its role osteogenic differentiation of mesenchymal stem cells (MSCs). Here, we detected critical function GCN5 commitment MSCs. In this role, HAT activity not required. Mechanistically, repressed nuclear factor kappa B (NF-κB)-dependent transcription inhibited...
To compare the accuracy, reliability, and reproducibility of a structured light scanning system stereophotogrammetry on human faces.A total 10 healthy volunteers were included in this study. After marking facial anatomy points, their faces scanned by system, three-dimensional (3D) images reconstructed with corresponding software. For each volunteer, was performed twice after calibration. Linear measurements calculated compared for two techniques direct caliper measurements. Absolute errors...
Abstract Bone tissue engineering may be hindered by underlying osteoporosis because of a decreased osteogenic ability autologous seed cells and an unfavorably changed microenvironment in these patients. Epigenetic regulation plays important role the developmental origins osteoporosis; however, few studies have investigated potential epigenetic therapy to improve or rescue bone marrow mesenchymal stem (BMMSCs) under osteoporotic conditions. Here, we pargyline, inhibitor lysine-specific...
Guided bone regeneration membranes have been effectively applied in oral implantology to repair defects. However, typical resorbable composed of collagen (Col) insufficient mechanical properties and high degradation rate, while non-resorbable need secondary surgery. Herein, we designed a photocrosslinkable collagen/polycaprolactone methacryloyl/magnesium (Col/PCLMA/Mg) composite membrane that provided spatiotemporal support effect after photocrosslinking. Magnesium particles were added the...
An iodine‐catalyzed aerobic oxidative domino annulation of methyl N‐heteroarenes with 6‐aminopyrimidine‐2,4‐dione and pyrazol‐5‐amine has been developed for the synthesis dipyrimidine/dipyrazolo‐fused pyridines using 1,3‐dibromobenzene as additive oxygen terminal oxidant. Detailed mechanistic studies indicated that enhanced solubility O2, facilitated oxidation I¯ to I2, thereby promoting cyclization reaction. The gram scale reaction was also successful this methodology.
Periodontal diseases are prevalent among middle-aged and elderly individuals. There's still no satisfactory solution for tooth loss caused by periodontal diseases. Human ligament stem cells (hPDLSCs) is a distinctive subgroup of mesenchymal cells, which play crucial role in supportive tissues, but their application value hasn't been fully explored yet. As regulatory subunit PI3K, PIK3R3's cell regulation remains poorly comprehended. This study aims to explore the effect PIK3R3 on...
Objective To quantitatively evaluate maxillary complete dentures fabricated from polylactic acid (PLA) using fused deposition modelling (FDM) technology. Methods A digital denture was prepared based on a standard edentulous plaster model. The PLA pattern printed by FDM machine, with 5 repetitions, while another wax patterns were as control group, high accuracy three-dimensional (3D) printer. scanned 3D scanner. light-body silicone film made after each had been totally seated the model, and...