A5067257648- Dental Health and Care Utilization
- Oral microbiology and periodontitis research
- Healthcare Systems and Reforms
- Pediatric health and respiratory diseases
- MicroRNA in disease regulation
- Child Nutrition and Water Access
- Bone Tissue Engineering Materials
- Extracellular vesicles in disease
- Global Maternal and Child Health
- Mesenchymal stem cell research
- Dental Education, Practice, Research
- Bone Metabolism and Diseases
- Health disparities and outcomes
- RNA Interference and Gene Delivery
- Tissue Engineering and Regenerative Medicine
- Gut microbiota and health
- Fluoride Effects and Removal
- TGF-β signaling in diseases
- HIV/AIDS oral health manifestations
- Electrospun Nanofibers in Biomedical Applications
- Circular RNAs in diseases
- Digestive system and related health
- Oral Health Pathology and Treatment
- Magnesium Alloys: Properties and Applications
- FOXO transcription factor regulation
Peking University
2016-2025
Stomatology Hospital
2016-2024
Guangdong Pharmaceutical University
2023-2024
King University
2019-2023
Beijing Haidian Hospital
2019-2023
National Clinical Research
2023
Metabolic Diseases Research Center
2023
Hefei University of Technology
2023
National Clinical Research Center for Digestive Diseases
2023
Shandong University
2020
To evaluate periodontal conditions in adults mainland China based on data from the 4th National Oral Health Survey.Data of adult subjects (35- to 44-year-old group [N = 4409], 55- 64-year-old 4622], and 65- 74-year-old 4428]) were analysed. Demographic, socio-economic, personal habit, dental history, health attitude obtained using a questionnaire. Periodontal condition was assessed standardized case definitions 2018 classification scheme. A multivariate analysis performed investigate...
Abstract Halitosis is a common symptom mainly caused by microbial activities in the oral cavity. Here, we used 16S rRNA gene pyrosequencing and metagenomic sequencing to examine compositions their functional variations children with halitosis. We found that tongue coating of subjects halitosis had greater bacterial richness than those healthy subjects. The relative abundance prevalence Leptotrichia wadei Peptostreptococcus stomatis were higher samples from without halitosis; Prevotella...
Abstract Objectives To explore the factors associated with utilization of oral health services among Chinese adults and older according to Andersen Behavior Model. Methods Data from 4th National Oral Health Survey (2015‐2016) in China were used. A total 7206 people (3669 aged 35‐44 years 3537 65‐74 years) included our analysis. service past 12 months was outcome variable. Explanatory variables selected Descriptive statistics bivariate associations (chi‐square tests) analysed, followed by...
Abstract Mesenchymal stem cells (MSCs) are widely used in the treatment of diseases. After their vivo application, MSCs undergo apoptosis and release apoptotic vesicles (apoVs). This study investigates role apoVs derived from human bone marrow mesenchymal (hBMMSCs) metabolism molecular mechanism observed effects. The results show that can promote osteogenesis inhibit osteoclast formation vitro vivo. ApoVs may therefore attenuate loss caused by primary secondary osteoporosis stimulate...
Abstract Background This study sought to evaluate dental utilization among 3-,4-, and 5-year-old children in China use Andersen’s behavioural model explore influencing factors, thereby providing a reference for future policy making. Methods is cross-sectional study. Data of 40,305 aged 3–5 years were extracted from the Fourth National Oral Health Survey, which was performed August 2015 December 2016. Patient data collected using questionnaire, answered by child’s parents, clinical during...
Guided bone regeneration membranes have been effectively applied in oral implantology to repair defects. However, typical resorbable composed of collagen (Col) insufficient mechanical properties and high degradation rate, while non-resorbable need secondary surgery. Herein, we designed a photocrosslinkable collagen/polycaprolactone methacryloyl/magnesium (Col/PCLMA/Mg) composite membrane that provided spatiotemporal support effect after photocrosslinking. Magnesium particles were added the...
D-mannose exhibits strong anti-inflammatory properties, but whether it has beneficial effects on preventing and treating osteoporosis remains unknown.Female, 12-month-old senile C57BL6/J mice (s-Man group) 8-week-old ovariectomized (OVX-Man were treated with in drinking water for 2 months (six mice/group). Microcomputed tomography analysis hematoxylin eosin staining performed to investigate the effect of attenuation bone loss. Tartrate-resistant acid phosphatase tissue sections, flow...
Abstract Background Astronauts undergo significant microgravity-induced bone loss during space missions, which has become one of the three major medical problems hindering human's long-term flight. A risk-free and antiresorptive drug is urgently needed to prevent missions. D-mannose a natural C-2 epimer D-glucose abundant in cranberries. This study aimed investigate protective effects potential mechanisms against under weightlessness. Methods The hind legs tail-suspended (TS) rats were used...
Abstract Aim The rising prevalence of periodontitis imposes substantial burdens on individuals and society. Identifying environmental risk factors for may contribute to tackling the global public health burden it. This study aimed assess association between long‐term exposure PM 2.5 in a nationally representative population from China. Materials Methods In this multi‐centre cross‐sectional 372 communities 31 provinces Mainland China, we used data Fourth National Oral Health Survey China...
Abstract Accumulating evidence has demonstrated that apoptotic vesicles (apoVs) derived from mesenchymal stem cells (MSCs; MSC-apoVs) are vital for bone regeneration, and possess superior capabilities compared to MSCs other extracellular (such as exosomes). The osteoinductive effect of MSC-apoVs is attributed their diverse contents, especially enriched proteins or microRNAs (miRNAs). To optimize osteoinduction activity, it necessary determine the unique cargo profiles MSC-apoVs. We...
Periodontal diseases are prevalent among middle-aged and elderly individuals. There's still no satisfactory solution for tooth loss caused by periodontal diseases. Human ligament stem cells (hPDLSCs) is a distinctive subgroup of mesenchymal cells, which play crucial role in supportive tissues, but their application value hasn't been fully explored yet. As regulatory subunit PI3K, PIK3R3's cell regulation remains poorly comprehended. This study aims to explore the effect PIK3R3 on...
To understand the oral health status of urban and rural residents in China, Fourth National Oral Health Epidemiological Survey (FNOHES) was conducted 2015. Based on principles multi-stage, stratified, equal capacity, random sampling, subjects included five groups aged 3–5, 12–15, 35–44, 55–64, 65–74 years all 31 provinces, cities, autonomous regions except Hong Kong, Macao, Taiwan. The total sample size 172,425. survey covered two areas, namely knowledge, attitude behavior. Residents China...
Bone defects are a common clinical condition that has gained an increasing amount of attention in recent years. Causes bone defect include tumors, inflammation, and fractures. tissue engineering is novel treatment defect, human mesenchymal stem cells (hMSCs) the ideal seed for due to their multi-lineage differentiation potential immunogenicity. The laminin α2 (LAMA2) gene encodes subunit laminins. Mutations this have been reported cause muscular dystrophy, but thus far no studies elucidated...
Abstract Background In tissue engineering, mesenchymal stem cells (MSCs) are common seed because of abundant sources, strong proliferation ability and immunomodulatory function. Numerous researches have demonstrated that MSC-macrophage crosstalk played a key role in the engineering. Macrophages could regulate differentiation MSCs via different molecular mechanisms, including extracellular vesicles. Apoptotic macrophages generate large amounts apoptotic vesicles (apoVs). ApoVs rich proteins,...
As the representative of fenamic acids, an important group NSAIDs, flufenamic acid (FFA) has been used for anti-inflammation and analgesia in clinic. Recently, researches have focused on role some members NSAIDs promoting osteogenesis. However, little attention paid to subgroup it remains unclear whether FFA other acids could regulate mesenchymal stem cells' (MSCs) lineage commitment bone regeneration. Here we treated two kinds human MSCs with at different concentrations vitro examined...
Mitochondrial phosphoenolpyruvate carboxykinase (PCK2) is a rate-limiting enzyme that plays critical roles in multiple physiological processes. The decompensation of PCK2 leads to various energy metabolic disorders. However, little known regarding the effects on osteogenesis by human mesenchymal stem cells (hMSCs). Here, we report novel function as positive regulator MSCs osteogenic differentiation. In addition its well-known role anabolism, demonstrate regulates autophagy. deficiency...
Poly-ε-caprolactone (PCL) is a promising synthetic material in bone tissue engineering (BTE). Particularly, the introduction of rapid prototyping (RP) represents possibility manufacturing PCL scaffolds with customized appearances and structures. Bio-Oss natural mineral matrix significant osteogenic effects; however, it has limitations being constructed maintained into specific shapes sites. In this study, we used RP fabricated hollow-structured cage-shaped scaffold loaded to form hybrid for...
Early childhood caries (ECC) is a widespread oral disease that harms children's health in China. Although previous studies have linked ECC prevalence to socioeconomic status, few measured the degree of inequality. This study aimed evaluate inequality children aged 3 5 years China and identify contributor We extracted data on 5-year-old from fourth National Oral Health Survey. by average household income per capita. used capita measure ECC. To describe both qualitatively quantitatively, we...
This study explored catastrophic health expenditure in China, due to out-of-pocket payments for dental care, and its associated individual- contextual-level factors. We pooled data from 31,566 adults who participated the third National Oral Health Survey with province-level different sources. defined (CDHE) as services and/or medication problems during last year that exceeded 10% 20% of household income. The association individual contextual factors was evaluated using two-level logistic...