A5018956614- Algebraic structures and combinatorial models
- Advanced Topics in Algebra
- Advanced biosensing and bioanalysis techniques
- Advanced Polymer Synthesis and Characterization
- Nonlinear Waves and Solitons
- Dendrimers and Hyperbranched Polymers
- Nanocluster Synthesis and Applications
- Organ Transplantation Techniques and Outcomes
- biodegradable polymer synthesis and properties
- Heat shock proteins research
- Polymer Surface Interaction Studies
- Nanopore and Nanochannel Transport Studies
- RNA Interference and Gene Delivery
- Nanoparticle-Based Drug Delivery
- Click Chemistry and Applications
- Hydrogels: synthesis, properties, applications
- Nanomaterials for catalytic reactions
- Advanced Nanomaterials in Catalysis
- Advanced Sensor and Energy Harvesting Materials
- Electrospun Nanofibers in Biomedical Applications
- Liver Disease and Transplantation
- Organic Electronics and Photovoltaics
- Advanced Harmonic Analysis Research
- Conducting polymers and applications
- Luminescence and Fluorescent Materials
China Pharmaceutical University
2025
Obstetrics and Gynecology Hospital of Fudan University
2021-2024
China University of Geosciences
2011-2024
Nationwide Children's Hospital
2012-2024
Nanjing Medical University
2013-2024
Jiangsu Province Hospital
2007-2024
117th Hospital of People's Liberation Army
2022-2024
Zhejiang University
2022-2024
Tsinghua University
2009-2024
Institute of Physics
2021-2024
The precise and large-scale identification of intact glycopeptides is a critical step in glycoproteomics. Owing to the complexity glycosylation, current overall throughput, data quality accessibility glycopeptide lack behind those routine proteomic analyses. Here, we propose workflow for high-throughput N-glycopeptides at proteome scale using stepped-energy fragmentation dedicated search engine. pGlyco 2.0 conducts comprehensive control including false discovery rate evaluation all three...
Abstract MicroRNAs (miRNAs) are being developed to enhance tissue regeneration. Here we show that a hyperbranched polymer with high miRNA-binding affinity and negligible cytotoxicity can self-assemble into nano-sized polyplexes ‘double-shell’ miRNA distribution transfection efficiency. These encapsulated in biodegradable microspheres enable controllable two-stage (polyplexes miRNA) delivery. The attached cell-free nanofibrous scaffolds spatially control the release of miR-26a. This...
Dual-crosslinked alginate hydrogels with a high Ca<sup>2+</sup> content were successfully prepared, which extended their properties, and showed potential application as skin strain sensor.
Abstract Background Remimazolam tosilate (HR7056, RT), a novel ultrashort-acting benzodiazepine, can be used for procedural sedation and general anaesthesia. However, few studies have focused on the sedative effect of RT during gastrointestinal endoscopy in elderly patients. The purpose this study is to compare propofol Methods A total 82 patients aged ≥65 years with an American Society Anaesthesiologists (ASA) grade I-II body mass index (BMI) 18.0 30.0 kg/m 2 who were scheduled from Jan...
Rationale: Liver ischemia-reperfusion (LI/R) injury is characterized by two interconnected phases: local ischemia that causes hepatic cell damage to release damage-associated molecular pattern (DAMPs), and DAMPs recruit immune cells elicit inflammatory cascade for further of hepatocytes.High-mobility group box 1 (HMGB1) a representative DAMP.Studies in macrophages demonstrated HMGB1 secreted after lactylation during sepsis.However, whether mediates secretion from hepatocytes LI/R known.Heat...
Nanopore sensing technology, as an emerging analytical method, has the advantages of simple operation, fast output, and label-free been widely used in fields such protein analysis, gene sequencing, biomarker detection. Inspired by biological ion channels, scientists have prepared various artificial solid-state nanopores/nanochannels. Biological channels extremely high transport selectivity, while nanopores/nanochannels poor selectivity. The selectivity nanopores nanochannels can be enhanced...
Myocardial ischemia/reperfusion (MI/R) injury is a major cause of adverse outcomes revascularization following myocardial infarction. Anaerobic glycolysis during ischemia well-studied, but the role aerobic early phase reperfusion incompletely understood. Lactylation Histone H3 (H3) an epigenetic indicator glycolytic switch. Heat shock protein A12A (HSPA12A) atypic member HSP70 family. In present study, we report that ischemia, HSPA12A was downregulated and flux decreased in cardiomyocytes....
Aptamer-based probes are pivotal components in various sensing strategies, owing to their exceptional specificity and versatile programmable structure. Nevertheless, numerous aptamer-based usually offer only a single function, limiting capacity meet the diverse requirements of multi-faceted systems. Here, we introduced supersandwich DNA (SSW-DNA), designed modified on outer surface nanochannels with hydrophobic inner walls, enabling dual functionality: qualitative detection for on-site...
The Friedewald formula (FF) is useful for calculating serum low-density lipoprotein cholesterol (LDL-C) values, but has a remarkable deviation and limitation especially in hypertriglyceridemia. We modify the which now more suitable LDL-C calculation. 2180 cases were classified into three groups according to their TG concentrations (A: < 200 mg/dl, n = 1220; B: 200-400 480; C: 400-1000 480). of measured or estimated by 1) direct measurement (DM); 2) FF; 3) our modified (MFF): (mg/dl)...
Herein, we report a facile fabrication of polymer (azobenzene and α-cyclodextrin-functionalized hyaluronic acid) gold nanobipyramids (AuNBs) conjugated mesoporous silica nanoparticles (MSNs) to be used as an injectable drug delivery system for sustained cancer treatment. Because the specific affinity between acid (HA) on MSNs CD44 antigen overexpressed tumor cells, can selectively attach cells. The nanocomposite material then exploits thermoresponsive interactions α-cyclodextrin azobenzene,...
In addition to T cells' roles in immune response and autoimmune diseases, certain types of cells, called regulatory cells (Tregs), play important microenvironment modulation for resolution tissue regeneration. However, there are currently few options available other than introducing more Tregs or immunosuppressive drugs locally enrich Tregs. Herein, poly(l-lactic acid) (PLLA) nanofibrous spongy microspheres (NF-SMS), PLLA/polyethylene glycol (PEG) co-functionalized mesoporous silica...
Combination of photodynamic therapy and chemotherapy has been emerging as a new strategy for cancer treatment. Conventional photosensitizer tends to aggregate in aqueous media, which causes fluorescence quenching, reduces reactive oxygen species (ROS) production, limits its clinical application therapy. Traditional nanoparticle drug delivery system also disadvantages, such low loading content, leakage, off-target toxicity normal tissues. Here, we developed reduction-sensitive co-delivery...
ADVERTISEMENT RETURN TO ISSUEPREVCommunication to the...Communication the EditorNEXTPreparation of Azido Polycarbonates and Their Functionalization via Click ChemistryXiaojin Zhang, Zhenlin Zhong*, Renxi Zhuo*View Author Information Key Laboratory Biomedical Polymers Ministry Education, Department Chemistry, Wuhan University, 430072, P. R. China*Tel +86 27 6875 4061; Fax 4509; e-mail [email protected] (Z.Z.), (R.Z.).Cite this: Macromolecules 2011, 44, 7, 1755–1759Publication Date (Web):March...
Stimuli-responsive polymeric micelles <italic>via</italic> click chemistry are divided into six major sections (temperature, light, ultrasound, pH, enzymes, and redox).
Mesoporous silica nanocarriers with pH-switchable antifouling zwitterionic surface, enzyme responsive drug release properties and blue fluorescence are reported. Prolonged circulation in the blood system zero premature as well efficient cellular uptake intracellular tumor tissue achieved.