A5100418899- Cancer-related molecular mechanisms research
- Lung Cancer Treatments and Mutations
- RNA modifications and cancer
- Cancer Immunotherapy and Biomarkers
- Lung Cancer Research Studies
- Circular RNAs in diseases
- Immunotherapy and Immune Responses
- Cancer, Hypoxia, and Metabolism
- Lung Cancer Diagnosis and Treatment
- Genetic factors in colorectal cancer
- Epigenetics and DNA Methylation
- Colorectal Cancer Treatments and Studies
- MicroRNA in disease regulation
- Pancreatic and Hepatic Oncology Research
- Immune Cell Function and Interaction
- Ferroptosis and cancer prognosis
- Cancer, Lipids, and Metabolism
- interferon and immune responses
- Cancer-related gene regulation
- Cancer Genomics and Diagnostics
- RNA Research and Splicing
- Gastric Cancer Management and Outcomes
- Cancer Cells and Metastasis
- Colorectal Cancer Screening and Detection
- MRI in cancer diagnosis
First Affiliated Hospital of Guangzhou Medical University
2023-2025
State Key Laboratory of Respiratory Disease
2021-2025
Union Hospital
2016-2025
Huazhong University of Science and Technology
2016-2025
Chinese Academy of Medical Sciences & Peking Union Medical College
2011-2025
Central Hospital of Wuhan
2018-2025
Shanghai Public Health Clinical Center
2017-2025
Sichuan University
2016-2025
Chongqing Medical University
2017-2025
Beijing Normal University
2025
The RAS/RAF signaling pathway is an important mediator of tumor cell proliferation and angiogenesis. novel bi-aryl urea BAY 43-9006 a potent inhibitor Raf-1, member the RAF/MEK/ERK pathway. Additional characterization showed that suppresses both wild-type V599E mutant BRAF activity in vitro. In addition, demonstrated significant against several receptor tyrosine kinases involved neovascularization progression, including vascular endothelial growth factor (VEGFR)-2, VEGFR-3, platelet-derived...
Causes of mortality are a crucial input for health systems identifying appropriate interventions child survival. We present an updated series cause-specific neonates and children younger than 5 years from 2000 to 2019.
Abstract HER2-directed therapies, such as trastuzumab and lapatinib, are important treatments for breast cancer. However, some tumors do not respond or develop resistance to these agents. We isolated characterized multiple lapatinib-resistant, HER2-positive, estrogen receptor (ER)–positive cancer clones derived from lapatinib-sensitive BT474 cells by chronic exposure lapatinib. show overexpression of AXL a novel mechanism acquired HER2-targeted agents in models. GSK1363089 (foretinib),...
Abstract The systemic immune-inflammation index (SII) based on peripheral lymphocyte, neutrophil and platelet counts has been considered a good that reflects the local immune response inflammation. However, use of SII not reported in cervical cancer. In this study, Kaplan-Meier survival analysis showed high was associated with poor prognosis cancer patients primary validation cohorts. A higher had significant correlation larger tumours but no other clinicopathological parameters. Among all...
Recently, more and evidence are rapidly accumulating that long noncoding RNAs (lncRNAs) involved in human tumorigenesis misregulated many cancers, including colon cancer. LncRNA could regulate essential pathways contribute to tumor initiation progression with their tissue specificity, which indicates lncRNA would be valuable biomarkers therapeutic targets. Colon cancer-associated transcript 1 (CCAT1) is a 2628 nucleotide-lncRNA located the vicinity of well-known transcription factor c-Myc....
Abstract Several studies have shown that tRNAs can be enzymatically cleaved to generate distinct classes of tRNA-derived fragments (tRF). Here, we report tRF/miR-1280, a 17-bp fragment derived from tRNALeu and pre-miRNA, influences Notch signaling pathways support the function cancer stem-like cells (CSC) in colorectal progression. tRF/miR-1280 expression was decreased human specimens cancer. Ectopic reduced cell proliferation colony formation, whereas its suppression reversed these effects....
Abstract Biomarkers such as programmed death receptor 1 ligand (PD-L1) expression, tumor mutational burden (TMB), and high microsatellite instability are potentially applicable to predict the efficacy of immune checkpoint blockade (ICB). However, several challenges defining cut-off value, test platform uniformity, low frequencies limit their broad clinical application. Here we identify comutations in DNA damage response (DDR) pathways homologous recombination repair mismatch (HRR-MMR) or HRR...
Purpose The receptors for hepatocyte and vascular endothelial cell growth factors (MET VEGFR2, respectively) are critical oncogenic mediators in gastric adenocarcinoma. purpose is to examine the safety efficacy of foretinib, an oral multikinase inhibitor targeting MET, RON, AXL, TIE-2, VEGFR2 receptors, treatment metastatic Patients Methods Foretinib tolerability, objective response rate (ORR) were evaluated patients using intermittent (240 mg/day, 5 days every 2 weeks) or daily (80 mg/day)...
Background and Purpose— Preliminary studies suggest that intracranial arteries are capable of accommodating plaque formation by remodeling. We sought to study the ability extent remodel using 3-dimensional high-resolution black blood magnetic resonance imaging investigate its relation ischemic events. Methods— Forty-two patients with cerebrovascular events underwent time-of-flight angiography contrast-enhanced examinations at 3 T for atherosclerotic disease. Each was classified location (eg,...
Background Immunotherapy has become an important treatment option for patients with advanced non-small cell lung cancer (NSCLC). At present, none of these existing biomarkers can effectively stratify true responders and there is urgent need identifying novel biomarkers. Exosomes derived from the serum have been proven to be reliable markers diagnosis. Here, we explored possibility using plasma-derived exosomal microRNAs as potential optimal selection EGFR/ALK negative NSCLC immunotherapy....
Rationale: Liver ischemia-reperfusion (LI/R) injury is characterized by two interconnected phases: local ischemia that causes hepatic cell damage to release damage-associated molecular pattern (DAMPs), and DAMPs recruit immune cells elicit inflammatory cascade for further of hepatocytes.High-mobility group box 1 (HMGB1) a representative DAMP.Studies in macrophages demonstrated HMGB1 secreted after lactylation during sepsis.However, whether mediates secretion from hepatocytes LI/R known.Heat...
Expression of a dominant negative mutant IFNgammaR1 in murine SCK and K1735 tumor cells rendered them relatively unresponsive to IFNgamma vitro more tumorigenic less responsive IL-12 therapy vivo. induced histologic evidence ischemic damage only IFNgamma-responsive tumors, vivo Matrigel vascularization assays revealed that while -unresponsive angiogenesis equally well, its downstream mediator inhibited by the cells. inhibitory activity cells, which may be attributable production chemokine...
Genome-wide association studies of lung cancer reported in populations European background have identified three regions on chromosomes 5p15.33, 6p21.33, and 15q25 that achieved genome-wide significance with p-values 10−7 or lower. These been performed primarily cigarette smokers, raising the possibility observed associations could be related to tobacco use, carcinogenesis, both. Since most women Asia do not smoke, we conducted a study adenocarcinoma never-smoking females (584 cases, 585...
Genome-wide association studies (GWAS) have recently identified KIF1B as susceptibility locus for hepatitis B virus (HBV)–related hepatocellular carcinoma (HCC). To further identify novel loci associated with HBV–related HCC and replicate the previously reported association, we performed a large three-stage GWAS in Han Chinese population. 523,663 autosomal SNPs 1,538 HBV–positive patients 1,465 chronic HBV carriers were genotyped discovery stage. Top candidate initial validation samples of...