Zhihua Yin
A5023597320- Cancer-related molecular mechanisms research
- RNA modifications and cancer
- MicroRNA in disease regulation
- Circular RNAs in diseases
- Systemic Lupus Erythematosus Research
- DNA Repair Mechanisms
- RNA Research and Splicing
- Epigenetics and DNA Methylation
- Genetic factors in colorectal cancer
- Immune Cell Function and Interaction
- T-cell and B-cell Immunology
- Lung Cancer Treatments and Mutations
- Glutathione Transferases and Polymorphisms
- Carcinogens and Genotoxicity Assessment
- Genetic Associations and Epidemiology
- Telomeres, Telomerase, and Senescence
- Ferroptosis and cancer prognosis
- interferon and immune responses
- Atherosclerosis and Cardiovascular Diseases
- Cancer-related Molecular Pathways
- Cytokine Signaling Pathways and Interactions
- Folate and B Vitamins Research
- Spondyloarthritis Studies and Treatments
- Cervical Cancer and HPV Research
- Cholangiocarcinoma and Gallbladder Cancer Studies
China Medical University
2016-2025
Shenzhen University Health Science Center
2022-2025
Nanchang University
2024-2025
Duke University
2025
Memorial Sloan Kettering Cancer Center
2024
University of California, Berkeley
2024
East China Normal University
2022-2024
Zhejiang Chinese Medical University
2023
Chongqing Medical University
2023
Tsinghua University
2022
Age-associated B cells (ABCs) accumulate during infection, aging, and autoimmunity, contributing to lupus pathogenesis. In this study, we screened for transcription factors driving ABC formation found that zinc finger E-box binding homeobox 2 (ZEB2) is required human mouse differentiation in vitro. ABCs are reduced ZEB2 haploinsufficient individuals mice lacking Zeb2 cells. with toll-like receptor 7 (TLR7)–driven lupus, essential autoimmune pathology. binds +20-kb myocyte enhancer factor 2b...
Lung adenocarcinoma is a heterogernous disease that creates challenges for classification and management. The purpose of this study to identify specific miRNA markers closely associated with the survival LUAD patients from large dataset significantly altered miRNAs, assess prognostic value expression profile OS in LUAD. We obtained profiles corresponding clinical information 372 Cancer Genome Atlas (TCGA), identified most miRNAs between tumor normal samples. Using analysis supervised...
Abstract Since most variants that impact polygenic disease phenotypes localize to non-coding genomic regions, understanding the consequences of regulatory element will advance human mechanisms. Here, we report systemic lupus erythematosus (SLE) risk variant rs2431697 as likely causal for SLE through disruption a element, modulating miR-146a expression. Using epigenomic analysis, genome-editing and 3D chromatin structure show tags cell-type dependent distal enhancer specific physically...
Recent evidence from several relatively small nested case‐control studies in prospective cohorts shows an association between longer telomere length measured phenotypically peripheral white blood cell (WBC) DNA and increased lung cancer risk. We sought to further explore this relationship by examining a panel of seven telomere‐length associated genetic variants large study 5,457 never‐smoking female Asian cases 4,493 controls using data previously reported genome‐wide study. Using group...
To evaluate associations by EGFR mutation status for lung adenocarcinoma risk among never-smoking Asian women, we conducted a meta-analysis of 11 loci previously identified in genome-wide association studies (GWAS). Genotyping an additional 10,780 cases and 10,938 controls from Asia confirmed with eight known single nucleotide polymorphisms (SNPs). Two new signals were observed at significance (P < 5 × 10-8), namely, rs7216064 (17q24.3, BPTF), overall risk, rs3817963 (6p21.3, BTNL2) which is...
Systemic lupus erythematosus (SLE) is a complex autoimmune disease characterized by augmented type I interferon signaling. High-throughput technologies have identified plenty of SLE susceptibility SNPs yet the exact roles most them are still unknown. Functional studies principally focused on in coding regions, with limited attention paid to noncoding regions. Long RNAs (lncRNAs) important players shaping immune response and show relationship diseases. In order reveal role located near...
Objective: Lupus nephritis (LN) is one of the most serious complications systemic lupus erythematosus (SLE). Type I interferon (IFN-I) associated with pathogenesis LN. Long non-coding RNAs (lncRNAs) have been implicated in SLE, however, roles lncRNAs LN are still poorly understood. Here, we identified and investigated function LN-associated lncRNA RP11-2B6.2 regulating IFN-I signaling pathway. Methods: RNA sequencing was used to analyze expression kidney biopsies from patients controls....
Despite strong evidence that human genetic variants affect the expression of many key transcription factors involved in autoimmune diseases, establishing biological links between non-coding risk and gene targets they regulate remains a considerable challenge. Here, we combine genetic, epigenomic, CRISPR activation approaches to screen for functional IRF8 expression. We demonstrate locus containing rs2280381 is cell-type-specific enhancer spatially interacts with promoter. Further, mediates...
Exosomal miRNAs have vital functions in mediating intercellular communication as well tumor occurrence and development. Thus, our research was aimed at exploring the regulatory mechanisms of exosomal miR-130b-3p/DEP domain containing 1 (DEPDC1)/transforming growth factor-β (TGF-β) signaling pathway non-small cell lung cancer (NSCLC). Here we indicated that miR-130b-3p expression decreased serum NSCLC patients, it significant diagnostic value. Moreover, elevated levels suppressed...
Abamectin is an insecticide, miticide and nematicide that has been extensively used in agriculture for many years. The excessive use of abamectin inevitably pollutes water soil might even cause adverse effects on aquatic biota. However, it currently unclear how exposure causes neurotoxicity organisms. Herein, the early neural system development was assessed zebrafish embryos following exposure. After treatment with a concentration gradient (0.055, 0.0825, 0.11 mg/L), survival rate, average...