A unique quintuple-modality theranostic nanoprobe (QMT) is developed with gold nanostars for surface-enhanced Raman scattering (SERS), magnetic resonance imaging (MRI), computed tomography (CT), two-photon luminescence (TPL) and photothermal therapy (PTT). The synthesized were tagged a SERS reporter linked an MRI contrast agent Gd3+. In vitro experiments demonstrated the QMT to be potential future biomedical applications.

Exosomal miRNAs have vital functions in mediating intercellular communication as well tumor occurrence and development. Thus, our research was aimed at exploring the regulatory mechanisms of exosomal miR-130b-3p/DEP domain containing 1 (DEPDC1)/transforming growth factor-β (TGF-β) signaling pathway non-small cell lung cancer (NSCLC). Here we indicated that miR-130b-3p expression decreased serum NSCLC patients, it significant diagnostic value. Moreover, elevated levels suppressed...

Purpose To provide visualization of the brachytherapy seeds and differentiation with natural structures in MRI by taking advantage their high magnetic susceptibility to generate positive‐contrast images. Methods The method is based on mapping using an equivalent short‐TE sequence a kernel deconvolution algorithm regularized L 1 minimization. An appealing aspect that signals from surrounding areas where signal noise ratio (SNR) sufficiently are used derive seeds, even though SNR immediate...

Single-dose preoperative stereotactic body radiotherapy is a novel technique for the early-stage breast cancer, and treatment response pattern of this needs to be investigated on quantitative basis. In work, dynamic contrast-enhanced magnetic resonance imaging diffusion-weighted were used study in unique cohort patients with cancer treated radiation. Fifteen female qualified received single-dose 1 3 prescription doses: 15 Gy, 18 21 Gy. Magnetic scans including both acquired before planning...

Abstract Magnetic resonance imaging (MRI) plays an important role in the modern radiation therapy (RT) workflow. In comparison with computed tomography (CT) imaging, which is dominant modality RT, MRI possesses excellent soft‐tissue contrast for radiographic evaluation. Based on quantitative models, can be used to assess tissue functional and physiological information. With developments of scanner design, acquisition strategy, advanced data analysis, modeling, multiparametric (mpMRI), a...

Recent developments in magnetic resonance (MR) functional quantitative imaging have made it a potentially powerful tool to assess treatment response radiation therapy. With its abilities capture information on underlying tissue characteristics, MR can be valuable assessing and as such optimize therapeutic outcome. Various techniques, including diffusion weighted imaging, tensor spectroscopy dynamic contrast enhanced been investigated found useful for assessment of radiotherapy. However,...

The fast MRI method of skipped phase encoding and edge deghosting (SPEED) is further developed with array coil enhancement, thus termed SPEED‐ACE. In SPEED‐ACE, space sparsely sampled at every step using a set receiver coils simultaneously, similar to SENSE, leading sensitivity‐weighted images up layers overlapping aliasing ghosts. ghosted are enhanced by differential filter yield maps, in which the ghost greatly reduced since sparseness edges reduces chance overlapping. Typical maps can be...

Abstract As biotechnology advances rapidly, a tremendous amount of cancer genetic data has become available, providing an unprecedented opportunity for understanding the mechanisms cancer. To understand effects duplications and deletions on progression, two genomes (normal tumor) were sequenced from each five stomach patients in different stages (I, II, III IV). We developed phylogenetic model analyzing data. The assumes that duplication deletion occur accordance with continuous time Markov...

This paper presents a new magnetic resonance imaging (MRI) phase correction method. The linear method using autocorrelation proposed by Ahn and Cho (AC method) is extended to handle nonlinear terms, which are often important for polynomial expansion of variation in MRI. coefficients statistically determined from cascade series n-pixel-shift rotational differential fields (RDFs). RDF represents local vector rotations complex field relative itself after being shifted n pixels. We have found...

To accelerate non-contrast-enhanced MR angiography (MRA) with inflow inversion recovery (IFIR) a fast imaging method, Skipped Phase Encoding and Edge Deghosting (SPEED).IFIR uses preparatory pulse to reduce signals from static tissue, while leaving arterial blood unaffected, resulting in sparse vasculature on modest tissue background. By taking advantage of vascular sparsity, SPEED can be simplified single-layer model achieve higher efficiency both scan time reduction image reconstruction....

To develop a 4-dimensional computerized magnetic resonance imaging phantom with image textures extracted from real patient scans for liver motion studies.The proposed was developed based on the current version of extended cardiac-torso and clinical scan. Initially, voxelized in abdominal-chest region at end exhalation phase. Structures/tissues were classified into 4 categories: (1) Seven key textured organs, including liver, gallbladder, spleen, stomach, heart, kidneys, pancreas, mapped...

The complete mitochondrial genome of the navel orangeworm Amyelois transitella (Insecta: Lepidoptera: Pyralidae) was assembled from Illumina sequencing reads (Illumina Inc., San Diego, CA). is a double-stranded circular molecule 15 205 bp, comprising 22 transfer RNAs (tRNAs), 13 protein-coding genes (PCGs), two ribosomal (rRNAs), and one control region. All PCGs are initiated with ATN codons, except for COX1 putative CGA initiation codon. Six (COX1, COX2, CYTB, ND2, ND3, ND4) harbor an...

The fast imaging method named skipped phase encoding and edge deghosting (SPEED) has been demonstrated to reduce scan time considerably with typical magnetic resonance data. In this work, SPEED is simplified improved efficiency accelerate the of sparse objects; we refer as S‐SPEED. S‐SPEED partially samples ‐space into two interleaved data sets, each same skip size but a different relative shift in encoding. sampled are then Fourier transformed ghosted images aliasing ghosts. Given...

This study compares the shutter-speed (SS) and Tofts models as used in assessing therapeutic response a longitudinal DCE-MRI experiment. Sixteen nu/nu mice with implanted colorectal adenocarcinoma cell line (LS-174T) were randomly assigned into treatment/control groups (n = 8/group) received bevacizumab/saline twice weekly (Day1/Day4/Day8). All scanned at one pre- (Day0) two post-treatment (Day2/Day9) time points using high spatiotemporal resolution pulse sequence. The CA extravasation rate...

Abstract The fast MRI method of Skipped Phase Encoding and Edge Deghosting (SPEED) is further developed to accelerate multiple acquisitions. In a single acquisition, SPEED first acquires three sparse ghosted edge maps with an undersampling factor N/3, which are modeled double‐layer structure described by equations two unknown ghosts, each unique ghost order index. By minimizing least‐square‐error, pair indexes determined. Based on them, the corresponding ghosts resolved, leading deghosted...

Abstract Study question Can artificial intelligence (AI) be used to forecast the number of oocyte collections that will occur at a clinic multiple days in advance? Summary answer An AI model can accurately predict how many across up seven advance. What is known already There exists significant variability duration ovarian stimulation for patients going through IVF, which often lead peaks and valleys workload embryology laboratory. On given day, laboratory being under or over resourced poor...

Abstract Context Primary adrenal lymphoma (PAL) is difficult to distinguish from other masses. Soluble interleukin-2 receptor (sIL-2R) a diagnostic biomarker for nodal non-Hodgkin lymphoma, whose association with PAL unknown. Objective The aim of this study was determine the utility serum sIL-2R Patients PAL. Design Prospective cohort study. Settings and Participants A total 118 patients masses who were willing be tested levels tertiary hospital between 2019 2021 included. Main Outcomes...

Purpose: Pre-operative stereotactic body radiosurgery (SBRT) was delivered in a single fraction to treat patients with early stage breast cancer; however, few data are available regarding radiation-induced changes by SBRT. In this work, diffusion weighted imaging (DWI) and dynamic contrast enhanced (DCE) MRI were used assess the following Methods: study, 24 cancer enrolled. A prescription dose of 15, 18 or 21Gy using intensity-modulated radiotherapy. Patients be scanned about 1-week before...

Purpose: T2‐weighted MR provides excellent delineation of malignant liver lesions due to its superior tumor‐to‐tissue contrast. This study aims develop a novel retrospective 4D‐MRI technique for imaging organ/tumor respiratory motion with improved soft‐tissue Method and Materials: Determine the number repeated scans (NR) required obtaining sufficient phase information each slice is critical component in developing this needs substantial testing many samples. To do that, computer simulations...

Purpose: To investigate the feasibility of using classic textural feature extraction in radiotherapy response assessment, we studied a unique cohort early stage breast cancer patients with paired pre - and post-radiation Diffusion Weighted MRI (DWI-MRI) Dynamic Contrast Enhanced (DCE-MRI). Methods: 15 female from our prospective phase I trial evaluating preoperative were included this retrospective study. Each patient received single-fraction radiation treatment, DWI DCE scans conducted...

Purpose: To develop a computerized pharmacokinetic model‐free Gross Tumor Volume (GTV) segmentation method based on dynamic contrastenhanced MRI (DCE‐MRI) data that can improve physician GTV contouring efficiency. Methods: 12 patients with biopsy‐proven early stage breast cancer post‐contrast enhanced DCE‐MRI images were analyzed in this study. A fuzzy c‐means (FCM) clustering‐based was applied to segment 3D from pre‐operative data. region of interest (ROI) is selected by...