Kexin Chen
A5100627368- Advanced ceramic materials synthesis
- RNA modifications and cancer
- Cancer-related molecular mechanisms research
- Cancer Genomics and Diagnostics
- MicroRNA in disease regulation
- Genetic Associations and Epidemiology
- Epigenetics and DNA Methylation
- Intermetallics and Advanced Alloy Properties
- MXene and MAX Phase Materials
- Cancer Risks and Factors
- Advanced materials and composites
- Lung Cancer Treatments and Mutations
- Circular RNAs in diseases
- Global Cancer Incidence and Screening
- Genetic factors in colorectal cancer
- Cancer Immunotherapy and Biomarkers
- Ferroptosis and cancer prognosis
- Cancer-related Molecular Pathways
- Nutrition, Genetics, and Disease
- BRCA gene mutations in cancer
- Breast Cancer Treatment Studies
- RNA Research and Splicing
- Immune cells in cancer
- Molecular Biology Techniques and Applications
- Gastric Cancer Management and Outcomes
Tianjin Medical University Cancer Institute and Hospital
2016-2025
Zhejiang University
2023-2025
Huazhong University of Science and Technology
2014-2025
Shanghai Model Organisms (China)
2025
Affiliated Hospital of Hangzhou Normal University
2025
Sichuan University
2012-2025
Hefei University of Technology
2024-2025
Harbin Medical University
2013-2025
Third Affiliated Hospital of Harbin Medical University
2013-2025
Ningxia Medical University
2022-2025
Background Colorectal cancer (CRC) remains one of the major types and related death worldwide. Sensitive, non-invasive biomarkers that can facilitate disease detection, staging prediction therapeutic outcome are highly desirable to improve survival rate help determine optimized treatment for CRC. The small non-coding RNAs, microRNAs (miRNAs), have recently been identified as critical regulators various diseases including may represent a novel class biomarkers. purpose this study was identify...
Despite the vital roles of reactive radical species in coupled iron–carbon composite/persulfate (PS) system for eliminating pollutants, nonradical contributions are typically overlooked. Herein, we developed two efficient magnetic iron–char composites via low-temperature (BCFe-400) and high-temperature (BCFe-700) pyrolysis. The activated PS through pathways sulfamethoxazole (SMX) degradation. In BCFe-400/PS system, high-valent iron Fe(IV) was dominant active oxidation, evidenced by methyl...
Fusion genes are chromosomal aberrations that found in many cancers and can be used as prognostic markers drug targets clinical practice. Fusions lead to production of oncogenic fusion proteins or enhanced expression oncogenes. Several recent studies have reported some escape microRNA regulation via 3'-untranslated region (3'-UTR) deletion. We performed whole transcriptome sequencing identify glioma discovered FGFR3-TACC3 fusions 4 48 glioblastoma samples from patients both mixed European...
MUC16, which encodes cancer antigen 125 (CA-125), is frequently mutated in gastric (GC); however, its association with tumor mutation load (TML) and outcome patients GC has not been established, to date.To investigate whether MUC16 mutations are associated TML prognosis GC.Statistical analysis of genomic data from 437 samples obtained The Cancer Genome Atlas (TCGA) 256 an Asian cohort. Both cohorts contained involved previous studies. Data were TCGA on September 3, 2017, the cohort March 5,...
Immune checkpoint blockade (ICB) therapies have revolutionized the treatment of human cancers including lung adenocarcinoma (LUAD).However, our understanding immune subtyping LUAD and its association with clinical response inhibitor remains incomplete.Here we performed molecular analysis from Cancer Genome Atlas (TCGA) validated findings TCGA cohort in 9 independent validation cohorts.We conducted consensus nonnegative matrix factorization (NMF).Potential ICB therapy was estimated Tumor...
Acral melanoma is a dismal subtype of occurring in glabrous acral skin, and has higher incidence East Asians. We perform single-cell RNA sequencing for 63,394 cells obtained from 5 3 cutaneous samples to investigate tumor heterogeneity immune environment. define orthogonal functional cell clusters that are involved TGF-beta signaling, Type I interferon, Wnt Cell cycle, Cholesterol efflux signaling. Signatures enriched TGF-beta, cholesterol signaling significantly associated with good...
Abstract Cancer of unknown primary (CUP) site poses diagnostic challenges due to its elusive nature. Many cases CUP manifest as pleural and peritoneal serous effusions. Leveraging cytological images from 57,220 at four tertiary hospitals, we developed a deep-learning method for tumor origin differentiation using histology (TORCH) that can identify malignancy predict in both hydrothorax ascites. We examined performance on three internal ( n = 12,799) two external 14,538) testing sets. In...
Epstein-Barr virus (EBV) infection is associated with clinical symptoms, treatment response, need for surgical intervention, and an enhanced likelihood of lymphoma among patients ulcerative colitis (UC). However, existing studies have primarily concentrated on the epidemiological associations between EBV UC, leaving mechanisms by which exacerbates poorly understood. Clinical specimens UC a mouse model dextran sulfate sodium-induced concurrent murine γ-herpesvirus 68 (MHV-68) were utilized to...
Most (70%) epithelial ovarian cancers (EOCs) are diagnosed late. Non-invasive biomarkers that facilitate disease detection and predict outcome needed. The microRNAs (miRNAs) represent a new class of biomarkers. This study was to identify validate plasma miRNAs as in EOC.We evaluated samples 360 EOC patients 200 healthy controls from two institutions. All were grouped into screening, training validation sets. We scanned the circulating by TaqMan low-density array screening set...
Studies of related individuals have consistently demonstrated notable familial aggregation cancer. We aim to estimate the heritability and genetic correlation attributable additive effects common single-nucleotide polymorphisms (SNPs) for cancer at 13 anatomical sites.
Genetic factors play an important role in the etiology of both sporadic and familial breast cancer. We aimed to discover novel genetic susceptibility loci for conducted a four-stage genome-wide association study (GWAS) 19,091 cases 20,606 controls East-Asian descent including Chinese, Korean, Japanese women. After analyzing 690,947 SNPs 2,918 2,324 controls, we evaluated 5,365 replication 3,972 3,852 controls. Ninety-four were further 5,203 5,138 finally top 22 investigated up 17,423...
Significance We have identified a lethal subtype of gastric cancer (GC) that is characterized by high levels clonal heterogeneity and TP53 (tumor protein P53) mutation. also uncovered key novel mutations in the targetable NRG1 (neuregulin-1) ERBB4 (V-Erb-B2 avian erythroblastic leukemia viral oncogene homolog 4) ligand-receptor pair BRCA2 (breast 2, early onset) as new genetic markers to predict better survival for GC. Our study represents approach GC personalized medicine clinical...
We have evaluated and provided evidence that the ryanodine receptor 3 gene (RYR3), which encodes a large protein forms calcium channel, is important for growth, morphology, migration of breast cancer cells. A putative binding site microRNA-367 (miR-367) exists in 3'UTR RYR3, genetic variant, rs1044129 A→G, present this region. confirmed miR-367 regulates expression reporter driven by RYR3 regulation was affected genotype. thermodynamic model based on base pairing secondary structure mRNA...