A5029009109- Hepatocellular Carcinoma Treatment and Prognosis
- Cancer-related molecular mechanisms research
- RNA modifications and cancer
- Liver Disease Diagnosis and Treatment
- Gut microbiota and health
- Cancer Immunotherapy and Biomarkers
- Immune Cell Function and Interaction
- Cardiac electrophysiology and arrhythmias
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Ultrasound and Hyperthermia Applications
- T-cell and B-cell Immunology
- Immunotherapy and Immune Responses
- Cancer-related gene regulation
- Colorectal Cancer Treatments and Studies
- Genetic Associations and Epidemiology
- Glutathione Transferases and Polymorphisms
- Pancreatic and Hepatic Oncology Research
- Epigenetics and DNA Methylation
- Cardiac Imaging and Diagnostics
- Lung Cancer Treatments and Mutations
- Cancer, Lipids, and Metabolism
- Ion channel regulation and function
- Carcinogens and Genotoxicity Assessment
- Liver Disease and Transplantation
- Colorectal Cancer Screening and Detection
Second Hospital of Anhui Medical University
2024-2025
Anhui Medical University
2020-2025
Chinese Academy of Sciences
2025
Shanghai Institute of Nutrition and Health
2025
Huzhou Central Hospital
2014-2024
Zhejiang Chinese Medical University
2023-2024
Huzhou University
2019-2024
Peking University
2006-2024
Dalian Ocean University
2011-2024
Southern Marine Science and Engineering Guangdong Laboratory (Guangzhou)
2022-2024
It is assumed that anti-CTLA-4 antibodies cause tumor rejection by blocking negative signaling from B7-CTLA-4 interactions. Surprisingly, at concentrations considerably higher than plasma levels achieved clinically effective dosing, the antibody Ipilimumab blocks neither B7 trans-endocytosis CTLA-4 nor binding to immobilized or cell-associated B7. Consequently, does not increase on dendritic cells (DCs) either CTLA4 gene humanized (Ctla4h/h) human CD34+ stem cell-reconstituted NSG™ mice. In...
Diabetes is a detriment to male reproductive health, notably through its capacity diminish secretion from accessory glands such as the seminal vesicles and prostate, which are crucial for function. Curcumin, naturally derived polyphenol renowned anti-inflammatory antioxidative attributes, has demonstrated potential in mitigating tissue damage across various organs diabetic patients. Despite established benefits, specific impact of curcumin on vesicle context diabetes remains underexplored....
Recent evidence from several relatively small nested case‐control studies in prospective cohorts shows an association between longer telomere length measured phenotypically peripheral white blood cell (WBC) DNA and increased lung cancer risk. We sought to further explore this relationship by examining a panel of seven telomere‐length associated genetic variants large study 5,457 never‐smoking female Asian cases 4,493 controls using data previously reported genome‐wide study. Using group...
Abstract Background The smoking prevalence among men in China is high, but the head and neck cancer incidence rates are low. This study's purpose was to investigate impact of tobacco, betel quid, alcohol on risk East Asia. Methods A multicenter case‐control study (921 patients with 806 controls) Asia conducted. odds ratio (OR) 95% confidence interval (CI) were estimated using logistic regression. Results Head risks elevated for tobacco (OR = 1.58), quid 8.23), 2.29). total attributable...
Non-small cell lung cancer (NSCLC) is one of the most common malignancies worldwide. In this study, we investigated Ultrahigh Performance Liquid Chromatography-Quadrupole Time-of-Flight Mass Spectrometry and Gas Chromatography Time-of-Flight/Mass Spectrometry-based non-targeted metabolomic profiles serum samples obtained from early-stage NSCLC patients healthy controls (HC). Metabolic pathways biological relevance potential biomarkers were extensively studied to gain insights into...
The Role of Contrast-Enhanced Sonography Focal Liver Lesions Before Percutaneous BiopsyWei Wu1, Min-Hua Chen1, Shan-Shan Yin1, Kun Yan1, Zhi-Hui Fan1, Wei Yang1, Ying Dai1, Ling Huo1 and Ji-You Li2Audio Available | Share
CD24 is overexpressed in nearly 70% human cancers, whereas TP53 the most frequently mutated tumour-suppressor gene that functions a context-dependent manner. Here we show both targeted mutation and short hairpin RNA (shRNA) silencing of retard growth, progression metastasis prostate cancer. competitively inhibits ARF binding to NPM, resulting decreased ARF, increase MDM2 decrease levels p53 target p21/CDKN1A. prevents functional inactivation by somatic viral oncogenes, including SV40 large T...
Aging is one of the factors leading to cancer. Gut microbiota related aging and colorectal cancer (CRC).A total 11 metagenomic data sets CRC were collected from R package curated Metagenomic Data. After batch effect correction, healthy individuals samples divided into three age groups. Ggplot2 Microbiota Process packages used for visual description species composition PCA in samples. LEfSe analysis was performed relative abundance healthy/CRC groups according age. Spearman correlation...
Mitochondrial DNA (mtDNA)-encoded proteins function in eukaryotes as subunits of respiratory complexes that also contain nuclear (nDNA)-encoded subunits. The importance functional interactions between mtDNA- and nDNA-encoded was previously demonstrated by testing the survivability cybrid cells or individuals containing nDNA mtDNA from different populations species. This report focuses on multisubunit complex cytochrome c oxidase (COX), made up both mtDNA-encoded A combination evolutionary...
Abstract Background The colorectum includes ascending colon, transverse descending sigmoid and rectum. Different sites of colorectal cancer (CRC) are different in many aspects, including clinical symptoms, biological behaviour, prognosis. Purpose This study aimed to analyse prognosis, genes, bacteria, fungi, microbial metabolome CRC. Methods Surveillance, Epidemiology, End Results (SEER) database STAT were used statistically describe the prognosis RNA sequences CRC from Broad Institute’s...
Abstract Background Sodium butyrate (NaB) is produced through the fermentation of dietary fiber that not absorbed and digested by small intestine. Purpose Here, we aimed to investigate effects NaB on proliferation, invasion, metastasis CRC cells their potential underlying molecular mechanism(s). Methods The cell counting kit-8 (CCK-8) assay EdU were used detect proliferation ability, flow cytometry was induction apoptosis cycle progression, scratch-wound healing transwell assays evaluate...
Immune checkpoint inhibitors (ICIs), such as nivolumab and ipilimumab, not only elicit antitumor responses in a wide range of human cancers but also cause severe immune-related adverse events (irAEs), including death. A largely unmet medical need is to treat irAEs without abrogating the immunotherapeutic effect ICIs. Although abatacept has been used irAEs, it risks neutralizing anti–cytotoxic T lymphocyte–associated protein 4 (CTLA-4) monoclonal antibodies administered for cancer therapy,...