A5100334845- Epigenetics and DNA Methylation
- Cancer Genomics and Diagnostics
- RNA modifications and cancer
- Cancer Cells and Metastasis
- Cancer-related gene regulation
- Microtubule and mitosis dynamics
- Genomics and Chromatin Dynamics
- Acute Myeloid Leukemia Research
- Prostate Cancer Treatment and Research
- Renal cell carcinoma treatment
- Cancer Research and Treatments
- Kruppel-like factors research
- Neuroblastoma Research and Treatments
- Chromosomal and Genetic Variations
- Protein Degradation and Inhibitors
- Cancer-related molecular mechanisms research
- Monoclonal and Polyclonal Antibodies Research
- Cancer-related Molecular Pathways
- Glioma Diagnosis and Treatment
- Gene expression and cancer classification
- Immunotherapy and Immune Responses
- RNA Research and Splicing
- Glutathione Transferases and Polymorphisms
- Histone Deacetylase Inhibitors Research
- Immune Cell Function and Interaction
The University of Texas MD Anderson Cancer Center
2016-2025
First Hospital of China Medical University
2025
Yangzhou University
2023-2025
The University of Texas Southwestern Medical Center
2022-2025
Sichuan Agricultural University
2023-2025
Wuhan Polytechnic University
2025
Second Hospital of Anhui Medical University
2025
Anhui Medical University
2025
Guangzhou University of Chinese Medicine
2022-2024
Shenzhen Institutes of Advanced Technology
2024
Primary biliary cirrhosis is a chronic granulomatous cholangitis, characteristically associated with antimitochondrial antibodies. Twin and family aggregation data suggest that there significant genetic predisposition to primary cirrhosis, but the susceptibility loci are unknown.To identify conferring risk for we carried out genomewide association analysis in which DNA samples from 2072 Canadian U.S. subjects (536 patients 1536 controls) were genotyped more than 300,000 single-nucleotide...
Importance Programmed cell death ligand 1 inhibitors combined with chemotherapy has changed the approach to first-line treatment in patients extensive-stage small lung cancer (SCLC). It remained unknown whether adding a programmed (PD-1) inhibitor provided similar or better benefits SCLC, which would add evidence on efficacy of checkpoint SCLC. Objective To evaluate and adverse event profile PD-1 serplulimab plus compared placebo as Design, Setting, Participants This international,...
In mammals, caloric restriction consistently results in extended lifespan. Epigenetic information encoded by DNA methylation is tightly regulated, but shows a striking drift associated with age that includes both gains and losses of at various sites. Here, we report epigenetic conserved across species the rate correlates lifespan when comparing mice, rhesus monkeys, humans. Twenty-two to 30-year-old monkeys exposed 30% since 7-14 years showed attenuation age-related compared ad libitum-fed...
Abstract MicroRNAs play important roles in regulating tumour development, progression and metastasis. Here we show that one of the miR-200 family members, miR-141, is under-expressed several prostate cancer (PCa) stem/progenitor cell populations both xenograft primary patient tumours. Enforced expression miR-141 CD44 + bulk PCa cells inhibits stem properties including holoclone sphere formation, as well invasion, suppresses regeneration Moreover, enforces a strong epithelial phenotype with...
Abstract The prostate gland mainly contains basal and luminal cells constructed as a pseudostratified epithelium. Annotation of epithelial transcriptomes provides foundation for discoveries that can impact disease understanding treatment. Here we describe genome-wide transcriptome analysis human benign prostatic populations using deep RNA sequencing. Through molecular biological characterizations, show the differential gene-expression profiles account their distinct functional properties....
To explore the roles played by specific human immunodeficiency virus type 1 (HIV-1) genes in determining vivo replicative capacity of AIDS viruses, we have examined replication kinetics and virus-specific immune responses rhesus monkeys following infection with two chimeric simian/human viruses (SHIVs). These were composed simian SIVmac239 expressing HIV-1 env associated auxiliary tat, vpu, rep. Virus was assessed during primary measuring plasma SIVmac p27 levels quantifying lymph nodes...
Acute myeloid leukemia (AML) is one of the most common types adult acute leukemia. Standard chemotherapies can induce complete remission in selected patients; however, a majority patients eventually relapse and succumb to disease. Thus, development novel therapeutics for AML urgently needed. Human C-type lectin-like molecule-1 (CLL-1) type II transmembrane glycoprotein, its expression restricted cells blasts. Moreover, CLL-1 expressed stem (LSCs), but absent hematopoietic (HSCs), which may...
DNMT3L (DNMT3-like), a member of the DNMT3 family, has no DNA methyltransferase activity but regulates de novo methylation. While biochemical studies show that is capable interacting with both DNMT3A and DNMT3B stimulating their enzymatic activities, genetic evidence suggests essential for DNMT3A-mediated methylation in germ cells dispensable during embryogenesis, which mainly mediated by DNMT3B. How what determines its functional specificity are not well understood. Here we DNMT3L-deficient...
Ductal carcinoma in situ (DCIS) is a noninvasive precursor lesion to invasive breast carcinoma. We still have no understanding on why only some DCIS lesions evolve cancer whereas others appear not do so during the life span of patient. Here, we performed full exome (tumor vs. matching normal), transcriptome, and methylome analysis 30 pure high-grade (HG-DCIS) 10 normal epithelial samples. Sixty-two percent HG-DCIS cases displayed mutations affecting driver genes or potential drivers....
Abstract Expression of androgen receptor (AR) in prostate cancer (PCa) is heterogeneous but the functional significance AR heterogeneity remains unclear. Screening ~200 castration-resistant PCa (CRPC) cores and whole-mount sections (from 89 patients) reveals 3 expression patterns: nuclear (nuc-AR), mixed nuclear/cytoplasmic (nuc/cyto-AR), low/no (AR −/lo ). Xenograft modeling demonstrates that + CRPC enzalutamide-sensitive resistant. Genome editing-derived AR-knockout LNCaP cell clones...
TET1 is a 5-methylcytosine dioxygenase and its DNA demethylating activity has been implicated in pluripotency reprogramming. However, the precise role of methylation regulation outside developmental reprogramming still unclear. Here, we show that overexpression catalytic domain but not full length (TET1-FL) induces massive global demethylation differentiated cells. Genome-wide mapping reveals 5-hydroxymethylcytosine production by TET1-FL inhibited as increases, which can be explained...
// Fuling Zhou 1, 2, * , Ming Li Yongchang Wei 3, Kevin Lin 4 Yue Lu Jianjun Shen Gary L. Johanning 1 Feng Wang-Johanning Viral Oncology Program, Center for Cancer and Metabolism, SRI International, Menlo Park, California, USA 2 Department of Clinical Hematology, Zhongnan Hospital, Wuhan University, Wuhan, Hubei, China 3 Radiation Medical Oncology, Epigenetics Molecular Carcinogenesis, Science The University Texas MD Anderson Center, Smithville, Texas, Co-first authors Correspondence to:...
Abstract Purpose: We investigated the role of human endogenous retrovirus type K (HERV-K) envelope (env) gene in pancreatic cancer. Experimental Design: shRNA was employed to knockdown (KD) expression HERV-K cancer cells. Results: env detected seven cell lines and 80% patient biopsies, but not two normal or uninvolved tissues. A new splice variant discovered several lines. Reverse transcriptase activity virus-like particles were observed culture media supernatant obtained from Panc-1 Panc-2...
// Chang Liu 1, 4 , Cathy Eng 1 Jianjun Shen 3 Yue Lu Yoko Takata Amir Mehdizadeh George J. 2 Miguel A. Rodriguez-Bigas Yanan Li Ping Yixiang Mao Manal M. Hassan Fangyu Wang Donghui Department of Gastrointestinal Medical Oncology, The University Texas MD Anderson Cancer Center, Houston, Texas, USA Surgical Epigenetics and Molecular Carcinogenesis, Smithville, Gastroenterology Hepatology, Jinling Hospital, Southern University, Nanjing, China Correspondence to: Li, email: dli@mdanderson.org...
The transcription factor SOX9 plays an essential role in determining the fate of several cell types and is a master regulation chondrocyte development. Our aim was to determine which genes genome chondrocytes are either directly or indirectly controlled by SOX9. We used RNA-Seq identify whose expression levels were affected ChIP-Seq those that harbor SOX9-interaction sites. For RNA-Seq, RNA profile primary Sox9flox/flox mouse infected with Ad-CMV-Cre compared same cells control adenovirus....