A5012126538- Hepatitis C virus research
- Liver Disease Diagnosis and Treatment
- Hepatitis B Virus Studies
- Cancer Mechanisms and Therapy
- GaN-based semiconductor devices and materials
- PI3K/AKT/mTOR signaling in cancer
- Immune Cell Function and Interaction
- Wind and Air Flow Studies
- Ga2O3 and related materials
- HIV Research and Treatment
- Protein Tyrosine Phosphatases
- Cytokine Signaling Pathways and Interactions
- Liver physiology and pathology
- Building Energy and Comfort Optimization
- Hearing, Cochlea, Tinnitus, Genetics
- interferon and immune responses
- T-cell and B-cell Immunology
- Neural dynamics and brain function
- Animal Vocal Communication and Behavior
- Liver Disease and Transplantation
- Monoclonal and Polyclonal Antibodies Research
- HIV/AIDS drug development and treatment
- Hearing Loss and Rehabilitation
- Cancer-related molecular mechanisms research
- Innovations in Concrete and Construction Materials
Fujian Medical University
2023-2025
Fuzhou Maternity and Child Health Care Hospital
2023-2025
Fujian Women and Children Hospital
2023-2025
Shandong First Medical University
2025
Massachusetts General Hospital
2015-2024
Harvard University
2015-2024
Chongqing University
2024
Tsinghua University
2003-2024
National Taipei University of Technology
2024
Taipei Veterans General Hospital
2024
Infection of the rhesus monkey with simian immunodeficiency virus macaques (SIVmax) was employed to explore early immune events associated initial containment an acute AIDS infection. In nine monkeys infected intravenously uncloned SIVmac strain 251, high-level p27 plasma antigenemia usually detected transiently from approximately day 7 through 21 following inoculation. replication in lymph nodes measured by situ RNA hybridization closely paralleled time course and magnitude viremia. The...
To explore the roles played by specific human immunodeficiency virus type 1 (HIV-1) genes in determining vivo replicative capacity of AIDS viruses, we have examined replication kinetics and virus-specific immune responses rhesus monkeys following infection with two chimeric simian/human viruses (SHIVs). These were composed simian SIVmac239 expressing HIV-1 env associated auxiliary tat, vpu, rep. Virus was assessed during primary measuring plasma SIVmac p27 levels quantifying lymph nodes...
ABSTRACT Emerging data have indicated that hepatitis C virus (HCV) subverts the host antiviral response to ensure its persistence. We previously demonstrated HCV protein expression suppresses type I interferon (IFN) signaling by leading reduction of phosphorylated STAT1 (P-STAT1). also core directly bound STAT1. However, detailed mechanisms which impacts IFN components not been fully clarified. In this report, we show interaction domain resides in N-terminal portion (amino acids [aa] 1 23)....
Near-ultraviolet nitride-based light-emitting diodes (LEDs) with peak emission wavelengths around 410 nm were fabricated onto c-face patterned sapphire substrates (PSS). It was found that the electroluminescence intensity of PSS LED shown 63% larger than conventional LED. For a typical lamp-form operating at forward current 20 mA, output power and external quantum efficiency estimated to be 10.4 mW 14.1%, respectively. The improvement in light could attributed decrease threading dislocations...
Single-cell analysis technologies such as mass cytometry allow for measurements of cellular heterogeneity with unprecedented dimensionality. Here, we applied dimensionality reduction and automated clustering methods on human T helper (TH) cells derived from peripheral blood tonsils, which showed differential cell composition extensive TH heterogeneity. Notably, this revealed numerous subtypes follicular (TFH) that followed a continuum spanning both tonsils. Furthermore, identified tonsillar...
Several genome-wide association studies (GWAS) have identified a genetic polymorphism associated with the gene locus for interleukin 28B (IL28B), type III interferon (IFN), as major predictor of clinical outcome in hepatitis C. Antiviral effects IFN family previously been shown against several viruses, including C virus (HCV), and resemble function I utilization intracellular Janus kinase signal transducer activator transcription (JAK-STAT) pathway. Effects unique to IL28B that would...
Spleen tyrosine kinase (SYK) plays a critical role in immune cell signaling pathways and has been reported as biomarker for human hepatocellular carcinoma (HCC). We sought to investigate the mechanism by which SYK promotes liver fibrosis evaluate therapeutic target fibrosis. evaluated cellular localization of association between expression fibrogenesis normal, hepatitis B virus (HBV)‐infected, C (HCV)‐infected non‐alcoholic steatohepatitis (NASH) tissue (n=36, 127, 22 30, respectively). A...
Background: Remodeling of the extracellular matrix (ECM) is a hallmark heart failure (HF). Our previous analysis secretome murine cardiac fibroblasts returned ADAMTS5 (a disintegrin and metalloproteinase with thrombospondin motifs 5) as one most abundant proteases. cleaves chondroitin sulfate proteoglycans such versican. The contribution its substrate versican to HF unknown. Methods: Versican remodeling was assessed in mice lacking catalytic domain (Adamts5 ΔCat ). Proteomics applied study...
Abnormal neddylation activation is frequently observed in human cancers and inhibition has been proposed as a therapy for cancer. Here, we report that MLN4924, small-molecule inhibitor of activating enzyme, increases glutamine uptake breast cancer cells by causing accumulation transporter ASCT2/SLC1A5, via inactivation CRL3-SPOP E3 ligase. We show the ligase SPOP promotes ASCT2 ubiquitylation, whereas itself auto-ubiquitylated upon deprivation. Thus, inversely regulate metabolism. knockdown...
Cellular immune responses mediated by CD8+ lymphocytes exert efficient control of virus replication during primary simian immunodeficiency (SIV) infection. However, the role that antibodies may play in early remains unclear. To evaluate how antibody affect SIVmac infection, we depleted rhesus monkeys B cells with anti-CD20 antibody. In normal immunized tetanus toxoid, treatment and resulting depletion inhibited generation antitetanus antibodies, while tetanus-specific T-cell were preserved....
Several groups of mammals such as bats, dolphins and whales are known to produce ultrasonic signals which used for navigation hunting by means echolocation, well communication. In contrast, frogs birds sounds during night- day-time hours that audible humans; their so pervasive together with those insects, they considered the primary nature. Here we show an Old World frog (Amolops tormotus) oscine songbird (Abroscopus albogularis) living near noisy streams reliably acoustic contain prominent...
Responses to alpha interferon (IFN-α)-based treatment are dependent on both host and viral factors vary markedly among patients infected with different hepatitis C virus (HCV) genotypes (GTs). Patients GT3 viruses consistently respond better IFN than do GT1 viruses. The mechanisms underlying this difference not well understood. In study, we sought determine the effects of HCV NS5A proteins from signaling. We found that overexpression either or significantly inhibited IFN-induced...
Abstract HCV replication disrupts normal endoplasmic reticulum (ER) function and activates a signaling network called the unfolded protein response (UPR). UPR is directed by three ER transmembrane proteins including ATF6, IRE1 PERK. increases TGF-β1 oxidative stress, which play important roles in liver fibrogenesis. has been shown to induce through generation of reactive oxygen species (ROS) p38 MAPK, JNK, ERK1/2 NFκB-dependent pathways. However, relationship between HCV-induced stress...