A5076484800- RNA modifications and cancer
- Cancer Cells and Metastasis
- Autonomous Vehicle Technology and Safety
- Ferroptosis and cancer prognosis
- Cytokine Signaling Pathways and Interactions
- Epigenetics and DNA Methylation
- Cancer-related gene regulation
- Kruppel-like factors research
- Real-time simulation and control systems
- Cancer, Hypoxia, and Metabolism
- Vehicle emissions and performance
- Cancer, Lipids, and Metabolism
- Wnt/β-catenin signaling in development and cancer
- Cancer-related molecular mechanisms research
- Mechanisms of cancer metastasis
- Traffic control and management
- FOXO transcription factor regulation
- AI in cancer detection
- Breast Lesions and Carcinomas
- Lung Cancer Treatments and Mutations
- Cancer-related Molecular Pathways
- 3D Printing in Biomedical Research
- MicroRNA in disease regulation
- Hippo pathway signaling and YAP/TAZ
- HER2/EGFR in Cancer Research
Zhejiang University
2021-2025
Sir Run Run Shaw Hospital
2021-2025
Ministry of Education of the People's Republic of China
2023
Technical University of Darmstadt
2023
Blood Center of Zhejiang Province
2021-2022
Jianghan University
2017
Abstract Ferroptosis, which is characterized by intracellular iron accumulation and lipid peroxidation, a newly described form of regulated cell death that may play key role in tumour suppression. In the present study, we investigated expression profiles biological effects fascin actin-bundling protein 1 (Fascin, gene name FSCN1 ) breast cancer. addition, bioinformatics analysis TCGA cancer database gain- loss-of-function studies showed Fascin enhances sensitivity to erastin-induced...
Abnormal neddylation activation is frequently observed in human cancers and inhibition has been proposed as a therapy for cancer. Here, we report that MLN4924, small-molecule inhibitor of activating enzyme, increases glutamine uptake breast cancer cells by causing accumulation transporter ASCT2/SLC1A5, via inactivation CRL3-SPOP E3 ligase. We show the ligase SPOP promotes ASCT2 ubiquitylation, whereas itself auto-ubiquitylated upon deprivation. Thus, inversely regulate metabolism. knockdown...
Abstract Triple-negative breast cancer is still a difficult point in clinical treatment at present, and deep study of its pathogenesis has great value. Therefore, our research mainly focuses on exploring the progression triple-negative determines important role HJURP/YAP1/NDRG1 transcriptional regulation axis cancer. We observed significantly increased HJURP expression levels compared to other subtypes. could affect level ubiquitination modification YAP1 protein then regulate downstream...
Rheumatoid arthritis (RA) is a debilitating systemic autoimmune disorder that significantly impairs quality of life. To elucidate the molecular alterations in RA progression, we performed comprehensive super-omics analyses on synovial tissues from patients with joint trauma, arthritis, and RA. These included transcriptomics, proteomics, metabolomics, microbiomics, fourteen PTMs (phosphorylation, acetylation, lactylation, O-GlcNAc glycosylation, arginine monomethylation, lysine dimethylation,...
Breast cancer is one of the most prevalent cancers among women, and early diagnosis crucial in reducing mortality rate. This study aims to identify novel, reliable, specific biomarkers for breast using 5-Hydroxymethylcytosine (5hmC) signatures circulating cell-free DNA (cfDNA). We utilized sensitive 5hmC seal method map profiles cfDNA samples from 203 patients 60 healthy individuals. Machine learning models were applied marker with high sensitivity specificity. A global loss was observed...
Background Triple-negative breast cancer is characterized by a poor prognosis and lack of targeted treatments, thus, new targeting markers therapeutic strategies are urgently needed. We previously indicated that PLAC8 promotes tumorigenesis exerts multidrug resistance in cancer. Therefore, we aimed to characterize the PLAC8-regulated network triple-negative Methods measured levels cell lines found post-translationally modified ubiquitin-fold modifier 1 (UFM1). Then, revealed regulatory...
Chemoresistance is a daunting challenge to the prognosis of patients with breast cancer. Signal transducer and activator transcription (STAT) 5a plays vital roles in development various cancers, but its function cancer controversial, role chemoresistance remains unexplored. Here we identified STAT5a as inducer that regulates expression ABCB1 can be targeted by pimozide, an FDA-approved psychotropic drug. First, found were expressed at higher levels doxorubicin-resistant cell lines...
Sorafenib is widely used in treating advanced hepatocellular carcinoma (HCC). However, its effectiveness prolonging patient survival limited by the development of drug resistance. To systematically investigate resistance mechanisms Sorafenib, an integrative analysis combining posttranslational modification (PTM) omics and CRISPR/Cas9 knockout library screening was conducted. This identified ubiquitination at lysine 21 (K21) on chaperonin-containing TCP1 subunit 3 (CCT3) as being associated...
In order to facilitate rapid prototyping and testing in the advanced motorsport industry, we consider problem of imitating outperforming professional race car drivers based on demonstrations collected a high-fidelity Driver-in-the-Loop (DiL) hardware simulator. We formulate contextual reinforcement learning learn human-like stochastic policy with domain-informed choices for states, actions, reward functions. To leverage very limited training data build diverse behavior, fit probabilistic...
BackgroundCancer-associated fibroblasts (CAFs) constitute the primary constituents of tumor microenvironment (TME) and exert significant influences on cancer progression. However, adequate comprehension CAF profiles in breast cancer, as well precise mechanisms underlying their promotion remains lacking.ObjectivesTo discerns biological differences between normal (NFs) CAFs explore mechanism.MethodsThree pairs NFs were isolated from patients diverse subtypes who had not undergone prior...
Drug resistance is a daunting challenge in the treatment of breast cancer, making it an urgent problem to solve studies. Cell lines are important tools basic and preclinical studies; however, few cell from drug-resistant patients available. Herein, we established novel HER2-positive cancer line pleural effusion metastatic patient. This has potent proliferative capability tumorigenicity nude mice but weak invasive colony-forming capability. The molecular subtype its sensitivity...
Accurate pathologic diagnosis and molecular classification of breast mass biopsy tissue is important for determining individualized therapy (neo)adjuvant systemic therapies invasive cancer. The CassiII rotational core system a novel technique with guide needle "stick-freeze" technology. comprehensive assessments including the concordance rates biomarker status between were evaluated in this study. Estrogen receptor (ER), progesterone (PgR), human epidermal growth factor 2 (HER2), Ki67...
The direction of electro-mechanical integration in advanced education is a comprehensive major which includes the collection machines, electricity, automatic control and detection, computer applications other disciplines.The orientation was determined, general knowledge, subject foundation, specialty, practice quality development developed, research teaching reform methods, improving staff structure put forward according to requirements, local economic construction social planning analysis...
Engineering a high-performance race car requires direct consideration of the human driver using real-world tests or Human-Driver-in-the-Loop simulations. Apart from that, offline simulations with human-like models could make this vehicle development process more effective and efficient but are hard to obtain due various challenges. With work, we intend provide better understanding behavior introduce an adaptive model based on imitation learning. Using existing findings interview professional...
Engineering a high-performance race car requires direct consideration of the human driver using real-world tests or human-driver-in-the-loop simulations. Alternatively, offline simulations with human-like models could make this vehicle development process more effective and efficient but are hard to obtain due various challenges. With work, we intend provide better understanding behavior from expert knowledge introduce an adaptive model based on imitation learning. Using existing findings in...