A5100633813- Genetic Associations and Epidemiology
- Bioinformatics and Genomic Networks
- Gene expression and cancer classification
- MicroRNA in disease regulation
- Cancer-related molecular mechanisms research
- RNA modifications and cancer
- Genetic Mapping and Diversity in Plants and Animals
- EEG and Brain-Computer Interfaces
- Epigenetics and DNA Methylation
- Folate and B Vitamins Research
- Immune cells in cancer
- RNA Research and Splicing
- Neurobiology of Language and Bilingualism
- Dementia and Cognitive Impairment Research
- Ferroptosis and cancer prognosis
- Neural dynamics and brain function
- Circular RNAs in diseases
- interferon and immune responses
- Cervical Cancer and HPV Research
- RNA regulation and disease
- Psoriasis: Treatment and Pathogenesis
- Single-cell and spatial transcriptomics
- Alzheimer's disease research and treatments
- AI in cancer detection
- Statistical Methods and Inference
Jiangsu University of Science and Technology
2024-2025
Affiliated Hospital of Jining Medical University
2024
Emory University
2017-2024
Anhui Medical University
2013-2024
Tongji University
2023-2024
Jiangsu University
2024
Second Hospital of Anhui Medical University
2013-2024
Soochow University
2024
China Tobacco
2024
Beijing Academy of Science and Technology
2024
Tamoxifen resistance remains a clinical challenge for hormone receptor-positive breast cancer. Recently, dysregulations in autophagy have been suggested as potential mechanism tamoxifen resistance. Although the long noncoding RNA H19 is involved various stages of tumorigenesis, its role unknown. Here, we assessed development tamoxifen-resistant Quantitative real-time PCR analyzed expression cancer tissues. Knockdown was used to assess sensitivity vitro and vivo. Both knockdown overexpression...
Abstract Numerous substrates have been identified for Type I and II arginine methyltransferases (PRMTs). However, the full substrate spectrum of only type III PRMT, PRMT7, its connection to PRMT remains unknown. Here, we use mass spectrometry reveal features PRMT7-regulated methylation. We find that PRMT7 predominantly methylates a glycine motif; multiple methylation sites are close phosphorylations sites; proximal sequences vulnerable cancer mutations; is enriched in proteins associated...
Psoriatic arthritis (PsA) is a complex chronic musculoskeletal condition that occurs in ~30% of psoriasis patients. Currently, no systematic strategy available utilizes the differences genetic architecture between PsA and cutaneous-only (PsC) to assess risk before symptoms appear. Here, we introduce computational pipeline for predicting among patients using data from six cohorts with >7000 genotyped PsC We identify 9 new loci or its subtypes achieve 0.82 area under receiver operator curve...
Autophagy and ferroptosis have been major foci of biomedical research in recent years. Elucidation their intrinsic molecular relationships is important for cancer prevention treatment. Metformin can directly inhibit tumorigenesis, although the mechanism responsible this not fully understood. Here, we demonstrate that metformin lncRNA‐H19 regulate both autophagy ferroptosis. inducers H19 reverse production lipid reactive oxygen species inhibition induced by metformin. The present study...
Most existing TWAS tools require individual-level eQTL reference data and thus are not applicable to summary-level datasets. The development of methods that can harness is valuable enable in broader settings enhance power due increased sample size. Thus, we develop a framework called OTTERS (Omnibus Transcriptome Test using Expression Reference Summary data) adapts multiple polygenic risk score (PRS) estimate weights from conducts an omnibus TWAS. We show practical powerful tool by both...
Mycoplasma pneumoniae (MP) is commonly detected in children. However, the epidemiological trends of MP Northeast (NE) China are unclear. This retrospective study aimed to investigate prevalence infections this understudied region. The clinical manifestations and bronchoscopic findings observed hospitalized patients with severe pneumonia (SMPP) were collected from comprehensive data obtained six tertiary hospitals NE Inner Mongolian (IM) China, 1 January 2017 31 December 2023. A total...
Abstract Late-life depression is associated with an increased risk for dementia but we have limited knowledge of the molecular mechanisms underlying this association. Here investigated whether brain microRNAs, important posttranscriptional regulators gene expression, contribute to depressive symptoms were assessed annually in 300 participants Religious Orders Study and Rush Memory Aging Project a mean 7 years. Participants underwent annual cognitive testing, clinical assessment status,...
Here microRNAs (miRNAs) with potentially therapeutic effects were screened and explored during liver fibrogenesis angiogenesis via targeting the important mediators. Chimera mice EGFP+ bone marrow mesenchymal stromal cells (BMSCs) fed methionine-choline-deficient high-fat (MCDHF) diet to induce injury. Increased expression of platelet-derived growth factor receptor-beta (PDGFR-β) was detected in MCDHF mice, a positive correlation fibrosis markers. BMSCs contributed significant proportion...
Genome‐wide association studies (GWAS) have revealed hundreds of genetic loci associated with the vulnerability to major psychiatric disorders, and post‐GWAS analyses shown substantial correlations among these disorders. This evidence supports existence a higher‐order structure psychopathology at both phenotypic levels. Despite recent efforts by collaborative consortia such as Hierarchical Taxonomy Psychopathology (HiTOP), this remains unclear. In study, we tested multiple alternative...
Transcriptome-wide association studies (TWAS) have been widely used to integrate transcriptomic and genetic data study complex human diseases. Within a test dataset lacking data, traditional two-stage TWAS methods first impute gene expression by creating weighted sum that aggregates SNPs with their corresponding cis-eQTL effects on reference transcriptome. Traditional then employ linear regression model assess the between imputed phenotype, thereby assuming effect of SNP phenotype is...
Ferroptosis, which is characterized by the accumulation of intracellular iron and subsequent lipid peroxidation, a newly discovered form regulated cell death plays an important role in tumor suppression. Herein, we showed that Polyphyllin III, major saponin extracted from Paris polyphylla rhizomes, exerted its proliferation-inhibitory effect on MDA-MB-231 triple-negative breast cancer cells mainly through ACSL4-mediated peroxidation elevation ferroptosis induction. ACSL4 deletion partly...
Abstract Cuproptosis is a newly discovered form of cell death. It regulated by string genes. The genes are identified to influence the tumor progression, but in glioma, cuproptosis-related little studied. Cancer Genome Atlas (TCGA) and Genotype-Tissue Expression (GTEx) were used screen for SLC31A1 gene expression glioma healthy tissue samples. results validated using Gene Omnibus (GEO) quantitative real-time polymerase chain reaction (qPCR). Human Protein (HPA) National Institute’s Clinical...
Long non‑coding RNA (lncRNA) H19 and Lin28 protein have been shown to participate in various pathophysiological processes, including cellular proliferation, autophagy epithelial‑mesenchymal transition (EMT). A number of studies investigated lncRNAs, microRNAs mRNAs, their roles the initiation progression cancer, doing so identifying competitive endogenous (ceRNA) networks, H19/let‑7/Lin28 network. However, whether ceRNA network is involved EMT breast cancer (BC) remains unclear. The present...
Background: Innate immune memory, also termed "trained immunity", is thought to protect against experimental models of infection, including sepsis.Trained immunity via reprogramming monocytes/ macrophages has been reported result in enhanced inflammatory status and antimicrobial activity infection sepsis.However, a safe efficient way induce trained remains unclear.Methods: β-glucan prototypical agonist for inducing immunity.Ferumoxytol, superparamagnetic iron oxide (SPIO) with low...
Abstract The therapeutic effect of mesenchymal stem cells (MSCs) on sepsis has been well-known. However, a comprehensive understanding the relationship between MSCs and macrophages remains elusive. Superparamagnetic iron oxide (SPIO) is one most commonly used tracers for MSCs. Our previous study shown that SPIO enhanced in macrophage-dependent manner. fate SPIO-labeled (MSC ) after infusion unknown direct interaction MSC unclear. Mice were injected intravenously with at 2 h Escherichia coli...
PRMT1 plays a vital role in breast tumorigenesis; however, the underlying molecular mechanisms remain incompletely understood. Herein, we show that critical RNA alternative splicing, with preference for exon inclusion. methylome profiling identifies methylates splicing factor SRSF1, which is SRSF1 phosphorylation, binding RNA, and In tumors, overexpression associated increased arginine methylation aberrant inclusion, are cancer cell growth. addition, identify selective inhibitor, iPRMT1,...
Transcriptome-wide association study (TWAS) is an influential tool for identifying genes associated with complex diseases whose genetic effects are likely mediated through transcriptome. TWAS utilizes reference and transcriptomic data to estimate effect sizes of variants on gene expression (i.e., a broad sense quantitative trait loci, eQTL). These estimated employed as variant weights in gene-based tests, facilitating the mapping risk genome-wide (GWAS) data. However, most existing...