A5100320351- Cancer-related molecular mechanisms research
- Cytokine Signaling Pathways and Interactions
- RNA modifications and cancer
- Circular RNAs in diseases
- Cancer-related gene regulation
- RNA Research and Splicing
- Epigenetics and DNA Methylation
- interferon and immune responses
- MicroRNA in disease regulation
- Cancer Immunotherapy and Biomarkers
- Inflammasome and immune disorders
- Genomics and Chromatin Dynamics
- Protein Degradation and Inhibitors
- Mechanisms of cancer metastasis
- Ubiquitin and proteasome pathways
- Crystallization and Solubility Studies
- Ferroptosis and cancer prognosis
- X-ray Diffraction in Crystallography
- RNA regulation and disease
- Protein Tyrosine Phosphatases
- RNA Interference and Gene Delivery
- Alzheimer's disease research and treatments
- Trace Elements in Health
- Genomics, phytochemicals, and oxidative stress
- Kruppel-like factors research
Xiamen University
2016-2025
Chongqing Medical University
2018-2025
First Hospital of China Medical University
2018-2025
China Medical University
2018-2025
Dalian Medical University
2020-2024
Institute of Hydrobiology
2023-2024
Nanjing University
2015-2024
Qingdao University
2017-2024
Second Affiliated Hospital of Chongqing Medical University
2020-2024
University of Chinese Academy of Sciences
2023-2024
Background: Smooth muscle cells (SMCs) play significant roles in atherosclerosis via phenotypic switching, a pathological process which SMC dedifferentiation, migration, and transdifferentiation into other cell types. Yet how SMCs contribute to the pathophysiology of remains elusive. Methods: To reveal trajectories during identify molecular targets for disease therapy, we combined fate mapping single-cell RNA sequencing both mouse human atherosclerotic plaques. We also performed biology...
Nonresolving inflammation in the intestine predisposes individuals to development of colitis-associated cancer (CAC). Inflammasomes are thought mediate intestinal homeostasis, and their dysregulation contributes inflammatory bowel diseases CAC. However, few agents have been reported reduce CAC by targeting inflammasomes. Here we show that small molecule andrographolide (Andro) protects mice against azoxymethane/dextran sulfate sodium-induced colon carcinogenesis through inhibiting NLRP3...
Progressive cerebral accumulation of tau aggregates is a defining feature Alzheimer’s disease (AD). A popular theory that seeks to explain the apparent spread neurofibrillary tangle pathology proposes aggregated passed from neuron neuron. Such templated seeding process requires transferred contains microtubule binding repeat domains are necessary for aggregation. While it not clear how protein such as can move cell cell, previous reports have suggested this may involve extracellular vesicles...
Abstract Numerous substrates have been identified for Type I and II arginine methyltransferases (PRMTs). However, the full substrate spectrum of only type III PRMT, PRMT7, its connection to PRMT remains unknown. Here, we use mass spectrometry reveal features PRMT7-regulated methylation. We find that PRMT7 predominantly methylates a glycine motif; multiple methylation sites are close phosphorylations sites; proximal sequences vulnerable cancer mutations; is enriched in proteins associated...
Abstract Esophageal cancer (EC) is a type of aggressive without clinically relevant molecular subtypes, hindering the development effective strategies for treatment. To define subtypes EC, we perform mass spectrometry-based proteomic and phosphoproteomics profiling EC tumors adjacent non-tumor tissues, revealing catalog proteins phosphosites that are dysregulated in ECs. The cohort stratified into two subtypes—S1 S2—based on analysis, with S2 subtype characterized by upregulation...
Abstract Background Esophageal squamous cell carcinoma (ESCC) is a common invasive malignancy worldwide with poor clinical outcomes. Increasing amount of long non-coding RNAs (lncRNAs) have been reported to be involved in cancer development. However, lncRNAs that are functional ESCC and the underlying molecular mechanisms remain largely unknown. Methods Transcriptomic analysis was performed identify dysregulated tissue samples. The high expression LINC00680 validated by RT-qPCR, oncogenic...
Abstract The molecular mechanisms underlying estrogen receptor (ER)‐positive breast carcinogenesis and endocrine therapy resistance remain incompletely understood. Here, we report that circPVT1, a circular RNA generated from the lncRNA PVT1, is highly expressed in ERα‐positive cancer cell lines tumor samples functionally important promoting tumorigenesis resistance. CircPVT1 acts as competing endogenous (ceRNA) to sponge miR‐181a‐2‐3p, expression of ESR1 downstream ERα‐target genes growth....
Soluble oligomers of amyloid β-protein (Aβ) have been defined as aggregates in supernatants following ultracentrifugation aqueous extracts from Alzheimer's disease (AD) brains and are believed to be upstream initiators synaptic dysfunction, but little is known about their structures. We now report the unexpected presence Aβ fibrils synaptotoxic high-speed AD extracted by soaking an buffer. The did not appear form during preparation, counts EM correlated with ELISA quantification. Cryo-EM...
Tyrosine phosphatase SHP2 is a promising drug target in cancer immunotherapy due to its bidirectional role both tumor growth promotion and T-cell inactivation. Its allosteric inhibitor SHP099 known inhibit cell vitro vivo. However, whether SHP099-mediated inhibition retards vivo via anti-tumor immunity remains elusive. To address this, CT-26 colon xenograft model was established mice since this line insensitive SHP099. Consequently, minimally affected immuno-deficient nude mice, but...
Aberrant activation of NLRP3 inflammasome has an important function in the pathogenesis various inflammatory diseases. Although many components and mediators have been identified, how is regulated to prevent excessive inflammation unclear. Here we show stimulators trigger Src homology-2 domain containing protein tyrosine phosphatase-2 (SHP2) translocation mitochondria, interact with dephosphorylate adenine nucleotide translocase 1 (ANT1), a central molecule controlling mitochondrial...
Transcriptional deregulation has a vital role in glioblastoma multiforme (GBM). Thus, identification of epigenetic modifiers essential for oncogenic transcriptional programs is key to designing effective therapeutics this deadly disease. Here we report that Protein Arginine Methyltransferase 2 (PRMT2) highly expressed GBM and correlated with poor prognosis. The silencing or inactivation PRMT2 inhibits cell growth stem self-renewal vitro, suppresses orthotopic tumor growth, accompanied...
Most tumor cells take up more glucose than normal cells. Splicing dysregulation is one of the molecular hallmarks cancer. However, role splicing factor in metabolism and development remains poorly defined. Here, we show that upon intake, SRSF5 specifically induced through Tip60-mediated acetylation on K125, which antagonizes Smurf1-mediated ubiquitylation. promotes alternative CCAR1 to produce CCAR1S proteins, promote growth by enhancing consumption acetyl-CoA production. Conversely,...
Abstract The methyltransferase like 3 (METTL3) has been generally recognized as a nuclear protein bearing oncogenic properties. We find predominantly cytoplasmic METTL3 expression inversely correlates with node metastasis in human cancers. It remains unclear if is functionally distinct from cytosolic driving tumorigenesis and, any, how tumor cells sense insults to coordinate functions within these intracellular compartments. Here, we report an acetylation-dependent regulation of localization...
Parkinson's disease (PD) is a neurodegenerative disorder characterized by the gradual loss of dopaminergic neurons in substantia nigra and accumulation α-synuclein aggregates called Lewy bodies. Here, nanodecoys were designed from rabies virus polypeptide with 29 amino acid (RVG29)-modified red blood cell membrane (RBCm) to encapsulate curcumin nanocrystals (Cur-NCs), which could effectively protect neurons. The RVG29-RBCm/Cur-NCs escaped reticuloendothelial system (RES) uptake, enabled...