A5061420460- Cancer-related molecular mechanisms research
- RNA Research and Splicing
- CRISPR and Genetic Engineering
- PARP inhibition in cancer therapy
- Circular RNAs in diseases
- Ferroptosis and cancer prognosis
- RNA modifications and cancer
Second Affiliated Hospital of Shantou University Medical College
2023
Shantou University
2023
Abstract The molecular mechanisms underlying estrogen receptor (ER)‐positive breast carcinogenesis and endocrine therapy resistance remain incompletely understood. Here, we report that circPVT1, a circular RNA generated from the lncRNA PVT1, is highly expressed in ERα‐positive cancer cell lines tumor samples functionally important promoting tumorigenesis resistance. CircPVT1 acts as competing endogenous (ceRNA) to sponge miR‐181a‐2‐3p, expression of ESR1 downstream ERα‐target genes growth....
Endocrine therapy is the frontline treatment for estrogen receptor (ER) positive breast cancer patients. However, primary and acquired resistance to endocrine drugs remain as a major challenge in clinic. Here, this work identifies an estrogen-induced lncRNA, LINC02568, which highly expressed ER-positive functional important cell growth vitro tumorigenesis vivo well drug resistance. Mechanically, demonstrates that LINC02568 regulates estrogen/ERα-induced gene transcriptional activation trans...
Nicotinamide N-methyltransferase (NNMT) and Dickkopf-1 (DKK1) play an important role in the development of breast cancer, purpose this study was designed to examine clinical prognostic significance NNMT DKK1 cancer.The GEPIA2 database used evaluate expression survival mRNA cancer. Then immunohistochemical carried out on 374 cases tissue identify protein DKK1. Next, cancer explored by COX Kaplan-Meier models.Protein correlated with lymph node metastasis histological grade (P < .05) while...