A5045642426- CRISPR and Genetic Engineering
- Plant Virus Research Studies
- MicroRNA in disease regulation
- Circular RNAs in diseases
- Cancer-related molecular mechanisms research
- Plant Micronutrient Interactions and Effects
- RNA modifications and cancer
- Cancer-related gene regulation
- Cassava research and cyanide
- Cellular Mechanics and Interactions
- Insect symbiosis and bacterial influences
- Retinal Diseases and Treatments
- NF-κB Signaling Pathways
- Melanoma and MAPK Pathways
- Algal biology and biofuel production
- RNA Research and Splicing
- Plant nutrient uptake and metabolism
- Epigenetics and DNA Methylation
- Animal Genetics and Reproduction
- Esophageal Cancer Research and Treatment
- Cancer-related Molecular Pathways
- Plant-Microbe Interactions and Immunity
- Transgenic Plants and Applications
- Extracellular vesicles in disease
- Cancer Cells and Metastasis
Henan Agricultural University
2020-2025
Beijing University of Chinese Medicine
2025
Chinese University of Hong Kong, Shenzhen
2025
First Affiliated Hospital of Zhengzhou University
2007-2024
Hetao College
2024
Xiamen University
2023
Inner Mongolia Agricultural University
2023
National Engineering Research Center for Wheat
2022
Nantong University
2021
Qingdao University
2021
Abstract The molecular mechanisms underlying estrogen receptor (ER)‐positive breast carcinogenesis and endocrine therapy resistance remain incompletely understood. Here, we report that circPVT1, a circular RNA generated from the lncRNA PVT1, is highly expressed in ERα‐positive cancer cell lines tumor samples functionally important promoting tumorigenesis resistance. CircPVT1 acts as competing endogenous (ceRNA) to sponge miR‐181a‐2‐3p, expression of ESR1 downstream ERα‐target genes growth....
Cutaneous melanoma is very aggressive and results in high mortality rates for cancer patients. Determining molecular targets important developing novel therapies cutaneous melanoma. Cell division cycle associated 8 (CDCA8) a putative oncogene that upregulated multiple types of cancer. The present study aimed to examine the role CDCA8 melanoma, with focus on association its expression prognosis metastasis. First, mRNA tissues was investigated using ONCOMINE Gene Expression Omnibus (GEO)...
The CRISPR/Cas9 system has recently been engineered to confer resistance geminiviruses in plants. However, we show here that the usefulness of this antiviral strategy is undermined by off-target effects identified deep sequencing Arabidopsis. We construct two virus-inducible vectors efficiently inhibit beet severe curly top virus (BSCTV) accumulation both transient assays (Nicotiana benthamiana) and transgenic lines (Arabidopsis). Deep detects no effect candidate sites This kind...
The recent advancements in developing the CRISPR/Cas9 system and various derivative tools (e.g., base editors) have accelerated basic plant science research crop improvement by creating multiple types of genetic variations (Li et al., 2023a). However, use Cas9 protein is frequently limited requirement G/C-rich protospacer-adjacent motif (PAM) sequences, especially triticeae plants, many which are important food forage crops carrying large complex genomes. CRISPR/CasΦ (CRISPR/Cas12j) has...
Viruses often usurp host machineries for their amplification, but it remains unclear if hosts may subvert virus proteins to regulate viral proliferation. Here, we show that the 17K protein, an important virulence factor conserved in barley yellow dwarf viruses (BYDVs) and related poleroviruses, is phosphorylated by GRIK1-SnRK1 kinases, with (P17K) capable of enhancing abundance virus-derived small interfering RNAs (vsiRNAs) thus antiviral RNAi. Furthermore, P17K interacts RNA-degrading...
Triple-negative breast cancer (TNBC) poses a major clinical challenge due to its aggressive progression and limited treatment options, making early diagnosis prognosis critical. MicroRNAs (miRNAs) are crucial post-transcriptional regulators that influence gene expression. In this study, we unveil novel miRNA-mRNA interactions introduce prognostic model based on miRNA-target interaction (MTI), integrating regulatory correlation inference the machine learning method effectively predict...
Summary The LRK10‐like receptor kinases (LRK10L‐RLKs) are ubiquitously present in higher plants, but knowledge of their expression and function is still limited. Here, we report functional analysis TtdLRK10L‐1, a typical LRK10L‐RLK durum wheat ( Triticum turgidum L. ssp. ). introns TtdLRK10L‐1 contained multiple kinds predicted cis ‐elements. To investigate the potential effect these ‐elements on function, two types transgenic lines were prepared, which expressed GFP‐tagged protein...
The epithelial to mesenchymal transition (EMT) is a key step during embryonic morphogenesis and plays an important role in drug resistance metastasis diverse solid tumors. We previously reported that 48 h treatment of anti-cancer doxorubicin could induce EMT human gastric cancer BGC-823 cells. However, the long term effects this transient were unknown. In study we found after with 0.1 μg/ml doxorubicin, most cells died next week, while minor population survived formed colonies. propagated...
To present and evaluate a remote, tool-based system structured grading rubric for adjudicating image-based diabetic retinopathy (DR) grades.We compared three different procedures DR severity assessments among retina specialist panels, including (1) in-person adjudication based on previously described procedure (Baseline), (2) assessing alone (TA), (3) using feature-based (TA-F). We developed allowing graders to review images remotely asynchronously. For both TA TA-F approaches, with...