A5100381468- Glioma Diagnosis and Treatment
- Radiomics and Machine Learning in Medical Imaging
- Cancer-related molecular mechanisms research
- MicroRNA in disease regulation
- Sarcoma Diagnosis and Treatment
- Bone Tumor Diagnosis and Treatments
- Circular RNAs in diseases
- Machine Learning in Materials Science
- Ferroptosis and cancer prognosis
- RNA modifications and cancer
- Immune cells in cancer
- Cancer Genomics and Diagnostics
- Parathyroid Disorders and Treatments
- Epigenetics and DNA Methylation
- interferon and immune responses
- Mesenchymal stem cell research
- Cancer Immunotherapy and Biomarkers
- RNA Research and Splicing
- Tumors and Oncological Cases
- Medical Imaging and Pathology Studies
- Cancer, Hypoxia, and Metabolism
- Oral and Maxillofacial Pathology
- Medical Imaging Techniques and Applications
- Cell Adhesion Molecules Research
- MRI in cancer diagnosis
Beijing Tian Tan Hospital
2016-2025
Capital Medical University
2016-2025
Huangshan University
2025
First Affiliated Hospital of Fujian Medical University
2021-2025
Fujian Medical University
2020-2025
Tianjin Medical University
2024-2025
Shenyang Agricultural University
2025
Tianjin Third Central Hospital
2025
Beijing Friendship Hospital
2024-2025
First Affiliated Hospital of Harbin Medical University
2014-2024
Abstract Purpose: Glioma tissues consist of not only glioma cells but also glioma-associated nontumor cells, such as stromal and immune cells. These dilute the purity play important roles in biology. Currently, implications variation are sufficiently clarified. Experimental Design: Here, tumor was inferred for 2,249 gliomas 29 normal brain from 5 cohorts. Based on transcriptomic profiling method, we classified CGGA TCGA-RNAseq cohorts RNAseq set discovery. Cases TCGA-microarray, REMBRANDT,...
The aim of this study was to develop a radiomics signature for prediction progression-free survival (PFS) in lower-grade gliomas and investigate the genetic background behind signature. In retrospective study, training (n = 216) validation 84) cohorts were collected from Chinese Glioma Genome Atlas Cancer Atlas, respectively. For each patient, total 431 features extracted preoperative T2-weighted magnetic resonance images. A generated cohort, its prognostic value evaluated both cohorts....
Intraoperative histology is essential for surgical guidance and decision-making. However, frozen-sectioned hematoxylin eosin (H&E) staining suffers from degraded accuracy, whereas the gold-standard formalin-fixed paraffin-embedded (FFPE) H&E too lengthy intraoperative use. Stimulated Raman scattering (SRS) microscopy has shown rapid of brain tissue with lipid/protein contrast but challenging to yield images identical nucleic acid-/protein-based FFPE stains interpretable pathologists. Here,...
Patients with high ALDH1A3-expressing glioblastoma (ALDH1A3hi GBM) show limited benefit from postoperative chemoradiotherapy. Understanding the mechanisms underlying such resistance in these patients is crucial for development of new treatments. Here, we that interaction between ALDH1A3 and PKM2 enhances latter's tetramerization promotes lactate accumulation stem cells (GSCs). By scanning lactylated proteome lactate-accumulating GSCs, XRCC1 undergoes lactylation at lysine 247 (K247)....
Abstract RNA is rarely used as a therapeutic target due to its flexible structure and instability. CRISPR‐Cas13a powerful tool for knockdown, the potential application of in cancer cells should be further studied. In this study, overexpression LwCas13a by lentivirus glioma reveals that crRNA‐EGFP induces “collateral effect” after knocking down gene EGFP‐expressing cells. EGFRvIII unique EGFR mutant subtype glioma, system death EGFRvIII‐overexpressing Bulk single‐cell sequencing analysis...
Although the treatment of brain tumors by targeting kinase-regulated macroautophagy/autophagy, is under investigation, precise mechanism underlying autophagy initiation and its significance in glioblastoma (GBM) remains to be defined. Here, we report that PAK1 (p21 [RAC1] activated kinase 1) significantly upregulated promotes GBM development. The Cancer Genome Atlas analysis suggests oncogenic role mainly associated with autophagy. Subsequent experiments demonstrate indeed serves as a...
Stem cells are characterized by their capability to self-renew and terminally differentiate into multiple cell types. Somatic or adult stem have a finite self-renewal capacity lineage-restricted. The use of for therapeutic purposes has been topic recent interest given the ethical considerations associated with embryonic (ES) cells. Mesenchymal (MSCs) that can osteogenic, adipogenic, chondrogenic, myogenic lineages. Owing ease isolation unique characteristics, MSCs widely regarded as...
Background: Researches on immunotherapy of glioma has been increasing exponentially in recent years. However, autoimmune-like side effects current immune checkpoint blockade hindered the clinical application glioma. The discovery TIM-3, a tumor-specific checkpoint, shed new light solution this dilemma. We aimed at investigating role TIM-3 transcriptome level and its relationship with practice glioma.Methods: A cohort 325 patients RNA-seq data from Chinese Glioma Genome Atlas (CGGA project)...
There has been no significant improvements for immune checkpoint inhibitors since its first use. Tumour-associated macrophages (TAMs) are critical mediators in the PD-1/PD-L1 axis, contributing to immunosuppressive tumour microenvironment. This study aims investigate potential role of PD-L1 regulating TAMs glioblastoma. Gene expression data and clinical information glioma patients were collected from TCGA (n = 614) CGGA 325) databases. Differentially expressed genes between high low groups...
P53 mutation status is a pivotal biomarker for gliomas. Here, we developed machine-learning model to predict p53 in lower-grade gliomas based on radiomic features extracted from conventional magnetic resonance (MR) images.Preoperative MR images were retrospectively obtained 272 patients with primary grade II/III The randomly allocated 2:1 ratio training (n = 180) or validation 92) set. A total of 431 each patient. lest absolute shrinkage and selection operator (LASSO) method was used feature...
Long-term potentiation (LTP) is a form of synaptic plasticity that results in enhanced strength. It associated with the formation and enlargement dendritic spines-tiny protrusions accommodating excitatory synapses. Both LTP spine remodelling are crucial for brain development, cognition pathophysiology neurological disorders. The role microRNAs (miRNAs) maintenance LTP, however, not well understood. Using next-generation sequencing to profile miRNA transcriptomes, we demonstrate miR-26a...
Transcriptional deregulation has a vital role in glioblastoma multiforme (GBM). Thus, identification of epigenetic modifiers essential for oncogenic transcriptional programs is key to designing effective therapeutics this deadly disease. Here we report that Protein Arginine Methyltransferase 2 (PRMT2) highly expressed GBM and correlated with poor prognosis. The silencing or inactivation PRMT2 inhibits cell growth stem self-renewal vitro, suppresses orthotopic tumor growth, accompanied...
Ferroptosis is a form of iron-dependent programmed cell death. Regulation ferroptosis in tumor cells novel treatment modality. The present study aimed to investigate ferroptosis-related long non-coding RNAs (lncRNAs) and construct prognostic model for colon adenocarcinoma (COAD). RNA- sequencing data genes were obtained from Cancer Genome Atlas database FerrDb database. COAD patients randomly assigned training- validation groups. Least Absolute Shrinkage Selection Operator regression Cox...
Objective: We aimed to summarize the clinicopathological characteristics and prognostic features of various molecular subtypes diffuse gliomas (DGs) in Chinese population. Methods: In total, 1,418 patients diagnosed with DG between 2011 2017 were classified into 5 according 2016 WHO classification central nervous system tumors. The IDH mutation status was determined by immunohistochemistry and/or DNA sequencing, 1p/19q codeletion detected fluorescence situ hybridization. median clinical...
The kynurenine pathway (KP) serves as the primary route for tryptophan metabolism in most mammalian organisms, with its downstream metabolites actively involved various physiological and pathological processes. Indoleamine 2,3-dioxygenase (IDO) (TDO) serve initial pivotal enzymes of KP, IDO playing important intricate roles cardiovascular diseases. Multiple KP have been observed to exhibit elevated concentrations plasma across diseases, such atherosclerosis, hypertension, acute myocardial...
Osteosarcoma (OS) is associated with poor prognosis due to its high incidence of metastasis and chemoresistance. It often arises in areas rapid bone growth long bones during the adolescent spurt. Although certain genetic conditions alterations increase risk developing OS, molecular pathogenesis poorly understood. Recently, defects differentiation have been linked cancers, as they are cell proliferation. Treatments overcoming these enable terminal subsequent tumor inhibition. OS development...
Gliomas are the most common malignant tumors of brain. Immune checkpoints have been increasingly emphasized as targets for treating tumors. B7‐H3 has identified an immune checkpoint that shows potential value targeting therapies. We set out to characterize expression pattern and biological function in brain gliomas using high‐throughput data obtained from Chinese Glioma Genome Atlas (CGGA) Cancer (TCGA) projects. was upregulated more higher‐grade than lower‐grade both CGGA TCGA datasets....
To investigate the association between imaging features and low-grade gliomas (LGG) related epilepsy, to propose a radiomics-based model for prediction of LGG-associated epilepsy. This retrospective study consecutively enrolled 286 patients with LGGs (194 in primary cohort 92 validation cohort). T2-weighted MR images (T2WI) were used characterize risk factors LGG-related epilepsy: Tumor location 3-D determined, following which interactions these two kinds analyzed. Elastic net was applied...
Abstract Amplification of epidermal growth factor receptor (EGFR) and active mutant EGFRvIII occurs frequently in glioblastoma (GBM) contributes to chemo/radio‐resistance various cancers, especially GBM. Elucidating the underlying molecular mechanism temozolomide (TMZ) resistance GBM could benefit cancer patients. A genome‐wide screening under a clustered regularly interspaced short palindromic repeats (CRISPR)‐Cas9 library is conducted identify genes that confer TMZ EGFRvIII‐expressing...
// Jinquan Cai 1,5,* , Pei Yang 2,4,5,* Chuanbao Zhang Wei Yanwei Liu 2,4,5 Zhaoshi Bao Xing 1,5 Wenzhong Du Hongjun Wang ,Tao Jiang 2,3,4,5 and Chuanlu 1 Department of Neurosurgery, The Second Affiliated Hospital Harbin Medical University, Harbin, China 2 Beijing Neurosurgical Institute, Capital University ,Beijing, 3 Institute for Brain Disorders Tumor Center 4 Tiantan Hospital, Beijing, 5 Chinese Glioma Cooperative Group (CGCG), * These authors contributed equally to the work...
Radiotherapy for esophageal squamous cell carcinoma (ESCC) patients is limited by resistance to ionizing radiation (IR). However, the roles and mechanisms of microRNAs in radioresistance are obscure. Here, we investigated that microRNA-205 (miR-205) was upregulated radioresistant (RR) ESCC cells compared with parental cells. Overexpression miR-205 promoted colony survival post-IR, whereas depletion sensitized IR vitro vivo. Further, demonstrated enhancing DNA repair, inhibiting apoptosis...
CDC-like kinase 3 (CLK3) is a dual specificity that functions on substrates containing serine/threonine and tyrosine. But its role in human cancer remains unknown. Herein, we demonstrated CLK3 was significantly up-regulated cholangiocarcinoma (CCA) identified recurrent Q607R somatic substitution represented gain-of-function mutation the domain. Gene ontology term enrichment suggested high expression CCA patients mainly associated with nucleotide metabolism reprogramming, which further...