A5077414771- Cancer-related molecular mechanisms research
- RNA modifications and cancer
- MicroRNA in disease regulation
- Circular RNAs in diseases
- Ubiquitin and proteasome pathways
- Biochemical and Molecular Research
- Epigenetics and DNA Methylation
- Autophagy in Disease and Therapy
- Histone Deacetylase Inhibitors Research
- Peptidase Inhibition and Analysis
- Cancer, Hypoxia, and Metabolism
- Cancer Cells and Metastasis
- PI3K/AKT/mTOR signaling in cancer
- Inflammasome and immune disorders
- Cancer-related Molecular Pathways
- TGF-β signaling in diseases
- Anesthesia and Neurotoxicity Research
- Cancer, Lipids, and Metabolism
- Adenosine and Purinergic Signaling
- Cancer-related gene regulation
- Berberine and alkaloids research
- NF-κB Signaling Pathways
- Diet, Metabolism, and Disease
- Cell death mechanisms and regulation
- Helicobacter pylori-related gastroenterology studies
Harbin Medical University
2016-2025
First Affiliated Hospital of Harbin Medical University
2016-2025
Duke Medical Center
2019-2021
Zunyi Medical University
2018
The Fifth People’s Hospital of Suzhou
2017
The role of LncRNA ADAMTS9-AS2 in the regulation chemoresistance gastric cancer (GC) is largely unknown. Here we found that was low-expressed GC tissues and cells compared to their normal counterparts. In addition, inhibited miR-223-3p expressions by acting as competing endogenous RNA, levels showed negative correlations tissues. Of note, overexpression cell viability motility sponging miR-223-3p. were lower, higher cisplatin-resistant (CR-GC) than parental cisplatin-sensitive (CS-GC) cells....
Abstract Pyroptosis is a type of regulated cell death executed by gasdermin family members. However, how gasdermin-mediated pyroptosis negatively remains unclear. Here, we demonstrate that mannose, hexose, inhibits GSDME-mediated activating AMP-activated protein kinase (AMPK). Mechanistically, mannose metabolism in the hexosamine biosynthetic pathway increases levels metabolite N -acetylglucosamine-6-phosphate (GlcNAc-6P), which binds AMPK to facilitate phosphorylation LKB1. Activated then...
Accumulating evidences show that long noncoding RNAs (lncRNA) play essential roles in the development and progression of various malignancies. However, their functions remains poorly understood many lncRNAs have not been defined colorectal cancer (CRC). In this study, we investigated role DLEU1 CRC.Quantitative real-time PCR was used to detect expression survival analysis adopted explore association between prognosis CRC patients. cells were stably transfected with lentivirus approach cell...
UVRAG (UV radiation resistance associated) is an important regulator of mammalian macroautophagy/autophagy by interacting with BECN1, PIK3C3, and RUBCN. Phosphorylation MTORC1 negatively regulates autophagosome maturation under nutrient-enriched conditions. However, how ubiquitination regulated still unknown. Here we report that ubiquitinated SMURF1 at lysine residues 517 559, which decreases the association RUBCN promotes maturation. deubiquitinase ZRANB1 specifically cleaves SMURF1-induced...
RIOK1 has recently been shown to play important roles in cancers, but its posttranslational regulation is largely unknown. Here we report that methylated at K411 by SETD7 methyltransferase and lysine-specific demethylase 1 (LSD1) reverses methylation. The mutated (K411R) cannot be exhibits a longer half-life than does the RIOK1. FBXO6 specifically interacts with K411-methylated through FBA domain induce ubiquitination. Casein kinase 2 (CK2) phosphorylates T410, which stabilizes antagonizing...
Abstract Altered expression of microRNA-590-5p (miR-590-5p) is involved in tumorigenesis, however, its role colorectal cancer (CRC) remains to be determined. In this study, we focused on examining the effects different levels miR-590-5p cells and normal cells. Results showed that there are lower human CRC tissues than control tissues. Similarly, our xenograft mouse model, knockdown promoted progression CRC. However, an overexpression mice inhibited angiogenesis, tumor growth, lung...
Colorectal cancer (CRC) is the second major cause of tumor-related deaths. MicroRNAs (miRNAs) have pivotal roles in CRC progression. Here, we describe effect miR-181d on cell metabolism and underlying molecular mechanism. Our data firmly demonstrated that knockdown suppressed proliferation, migration, invasion by impairing glycolysis. Mechanistically, stabilized c-myc through directly targeting 3'-UTRs CRY2 FBXL3, which subsequently increased glucose consumption lactate production....
CDC-like kinase 3 (CLK3) is a dual specificity that functions on substrates containing serine/threonine and tyrosine. But its role in human cancer remains unknown. Herein, we demonstrated CLK3 was significantly up-regulated cholangiocarcinoma (CCA) identified recurrent Q607R somatic substitution represented gain-of-function mutation the domain. Gene ontology term enrichment suggested high expression CCA patients mainly associated with nucleotide metabolism reprogramming, which further...
// Xuehui Hong 1, 2, * , Yang Xu 3, Xingfeng Qiu Yuekun Zhu 4 Xing Feng 5 Zhijie Ding 1 Shifeng Zhang Lifeng Zhong Yifan Zhuang Chen Su Xinya 6 Jianchun Cai 2 Department of Gastrointestinal Surgery, Zhongshan Hospital Xiamen University, Xiamen, Fujian, China Institute Oncology, Medical College 3 General The Second Affiliated Harbin Harbin, Heilongjiang, First Radiation Cancer New Jersey, Rutgers Brunswick, USA Imaging and Ultrasound, These authors contributed equally to this work...
TRAF-binding domain (Trabid), one of deubiquitination enzymes, was recently reported to activate Wnt/ β-catenin signaling pathway. However, the role Trabid in tumors including hepatocellular carcinoma (HCC) and underlying mechanisms controlling its activity remain poorly understood. Here, we report that is significantly downregulated HCC tumor samples cell lines compared with normal controls expression level negatively correlated pathological grading, recurrence, metastasis. The...
Cancer cells metabolize different energy sources to generate biomass rapidly. The purine biosynthetic pathway was recently identified as an important source of metabolic intermediates for these processes. However, very little known about the regulatory mechanisms metabolism in hepatocellular carcinoma (HCC). We explored role dual‐specificity tyrosine (Y) phosphorylation–regulated kinase 3 (Dyrk3) HCC metabolism. Dyrk3 significantly down‐regulated compared with normal controls. Its...
Background: Slow transit constipation (STC) is an intestinal disease characterized by colonic dyskinesia which involves multiple factors such as neuroendocrine, substance metabolism, gut microbiota, ion channels, and aquaporin. Increasing evidence indicates that modulation of immune signaling, activation cells, secretion cytokines impact oxidative stress, disruption the mucosal barrier subsequent dysfunction in STC. However, landscape microenvironment (IME) disease-specific cell type STC...
Background: Colorectal cancer (CRC) is one of most common cancers worldwide. Long non-coding RNA SNHG6 has been reported to act as essential regulators in several cancers. However, the functional role and molecular mechanism colorectal remain unclear. Methods: Quantitative real-time polymerase chain reaction (PCR) was performed evaluate expression CRC tissues. Colony formation, transwell assays vivo mice models were carried out assess effect on biological functions. Results: In present...
Cyclovirobuxine D (CVB‑D) is an alkaloid, which mainly derived from Buxus microphylla. It has been reported that CVB‑D positive effects on breast cancer, gastric cancer and other malignant tumors. However, to the best of our knowledge, there are no reports regarding colorectal (CRC). The purpose present study was determine anticancer further elucidate its molecular mechanism(s). DLD‑1 LoVo cell lines were selected evaluate antitumor effect CVB‑D. Cytotoxicity, viability proliferation...
The difference between left- and right-sided colon cancer has become the focus of global attention, researchers have found differences in morbidity, molecular biological characteristics, response to targeted drug therapy cancer. Therefore, identification more effective predictive indicators is critical for providing guidance future clinical work. We collected samples from different sites regions analyzed identities distributions differentially expressed species microbiota left right sides...
Despite considerable recent advancements in colorectal cancer (CRC) therapy, the prognosis of patients with advanced disease remains poor. Further understanding molecular mechanisms and treatment strategies this is required. Zinc finger protein 692 (ZNF692), also known as AREBP Zfp692, was first reported to have an important role gluconeogenesis. A study demonstrated that ZNF692 overexpressed lung adenocarcinoma (LUAD) tissues knockdown inhibited LUAD cell proliferation, migration, invasion...
Abstract The abnormal expression of adipocyte enhancer binding protein 1 (AEBP1) has been implicated in the carcinogenesis and progression various types human tumors. However, role AEBP1 colon adenocarcinoma (COAD) remains largely unelucidated. In this study, we explored clinical significance biological function COAD. We observed that was overexpressed COAD tissues cells correlated with tumor size, level histologic differentiation, lymph node metastasis, cancer stage patients. addition,...
Objective To investigate the protective effects of dexmedetomidine (DEX) in oxygen-glucose deprivation/reoxygenation (OGD/R) injury, which is involved a number ischaemic diseases. Methods An vitro OGD/R injury model was generated using mouse Neuro 2A neuroblastoma (N2A) cells. Different concentrations DEX were administrated to CV-65 used inhibit p38 microtubule associated protein kinase/extracellular signal-regulated kinases (MAPK/ERK) signalling. Cell proliferation, cell cycle, apoptosis,...
Purpose: Hepatocellular carcinoma (HCC) is one of the most common malignant tumors. The biological behavior HCC closely related to epithelial-mesenchymal transition (EMT), and EMT plays an important role in progression, migration metastasis HCC. P21-activated kinase 3 (PAK3) a serine/threonine protein kinase, PAK3 affects EMT, proliferation, invasion Methods: In this study, relationship between was first analyzed by bioinformatics, then, expression clinical samples detected...