Abstract Although nanomaterial‐mediated phototherapy, in particular photothermal therapy (PTT) and photodynamic (PDT), is extensively investigated recent years, the ablation mechanism, evolution, rehabilitation process of vivo solid tumor after phototherapy are rarely explored yet remain a terra incognita. Herein, kind bismuth ferrite nanoparticles (abbreviated as BFO NPs) strategically designed synthesized with desirable size bioactivity brand‐new phototherapeutic agent for which strong...

The epithelial-to-mesenchymal transition (EMT) program is critical for epithelial cell cancer progression and fibrotic diseases. FOXO1 influences a broad range of physiological pathological processes. However, the mechanism by which inhibits EMT not fully understood. In this study, we demonstrated that overexpression inhibited motility invasiveness in vitro lung metastasis vivo. addition, found couldreverse program. silencing siRNA hepatocellular carcinoma (HCC) lines enhanced expression...

Abstract Background Nuciferine (NF), extracted from the leaves of N. nucifera Gaertn , has been shown to exhibit anti-tumor and anti-viral pharmacological properties. It can also penetrate blood brain barrier (BBB). However, mechanism by which NF inhibits glioblastoma (GBM) progression is not well understood. We aimed determine effect on GBM cell lines clarify potential molecular involved. Methods U87MG U251 were used in vitro assess efficacy NF. Cytotoxicity, viability, proliferation...

Sonophotocatalysis is one of the most significant outcomes exploration interaction between piezoelectric field and charge carriers, which exhibits potential applications in dye degradation, water splitting, sterilization. Although several heterojunction catalysts have been applied to improve sonophotocatalytic capability, importance morphology on capability has not emphasized. In this study, brush-like ZnO nanorod arrays are synthesized a stainless-steel mesh subsequently vulcanized into...

CD4+ CD25+ regulatory T cells (Tregs), a crucial component of the infiltration immune in tumor microenvironment, are associated with progression and metastasis hepatocellular carcinoma (HCC).The mechanism Tregs invasion HCC was investigated vivo vitro using immunohistochemical analysis, western blot, quantitative reverse transcription-PCR (qRT-PCR).Analysis 78 clinical samples indicated that high expression strongly poor cancer-free survival overall patients. The reduced E-cadherin enhanced...

Of all pathological types of renal cell cancer (RCC), clear carcinoma (ccRCC) has the highest incidence.Cyclovirobuxine (CVB), a triterpenoid alkaloid isolated from Buxus microphylla, exhibits antitumour activity against gastric and breast cancer; however, mechanism by which CVB inhibits ccRCC remains unclear.The aim our study was to explore effects on elucidate its exact mechanism.Cell viability, proliferation, cycle distribution, apoptosis, wound healing invasion were...

Oxidative stress and inflammatory responses are critical factors in calcium oxalate (CaOx) crystal-induced renal injury. Reactive oxygen species (ROS) usually produced the cytoplasm mitochondria trigger priming activation of NLRP3 inflammasome, thereby regulating cytokines inflammation. Polydatin is a plant rhizome extract with anti-inflammatory, antioxidant, antitumor effects. However, it remains not clear whether how these pathophysiological processes exists CaOx injury.Here, we measured...

Glioblastoma multiforme (GBM) has been considered the most aggressive glioma type.Temozolomide (TMZ) is main first-line chemotherapeutic agent for GBM.Decreased mutS homolog 6 (MSH6) expression clinically recognized as one of principal reasons GBM resistance to TMZ.However, specific functions MSH6 in GBM, addition its role mismatch repair, remain unknown.Methods: Bioinformatics were employed analyze mRNA and protein levels clinical samples predict potential cancer-promoting mechanisms...

Cryptotanshinone (CTT), extracted from the root of Salvia miltiorrhiza Bunge (Danshen), exhibits activities against a variety human cancers in vitro and vivo. The purpose this study was to investigate potential inhibitory effect CTT on bladder cancer. In study, we found that inhibited cancer cell proliferation, migration, invasion promoted apoptosis. addition, modulated expression proteins via PI3K/AKT pathway, inhibition signalling due induction PTEN expression. Taken together, results...

Lung cancer is the leading cause of cancer‑related mortality worldwide. Non‑small cell lung (NSCLC) most common pathological subtype and associated with low 5‑year overall survival rates. Therefore, novel effective chemotherapeutic drugs are urgently required for improving outcomes patients cancer. Cyclovirobuxine D (CVB‑D) a natural steroidal alkaloid, used treatment cardiovascular diseases in Traditional Chinese Medicine. Several studies have also demonstrated antitumor effects CVB‑D....

Cyclovirobuxine D (CVB‑D) is an alkaloid, which mainly derived from Buxus microphylla. It has been reported that CVB‑D positive effects on breast cancer, gastric cancer and other malignant tumors. However, to the best of our knowledge, there are no reports regarding colorectal (CRC). The purpose present study was determine anticancer further elucidate its molecular mechanism(s). DLD‑1 LoVo cell lines were selected evaluate antitumor effect CVB‑D. Cytotoxicity, viability proliferation...

Green synthesized 3D CuS hollow nanoflowers are for the first time proved to be a <italic>T</italic>₁ positive MRI contrast agent imaging-guided thermochemotherapy.

Polydatin, extracted from Polygonum cuspidatum, is known for its anti-platelet aggregation and anti-inflammatory effects. However, studies on the association of polydatin with cancer are limited, particularly regards to epithelial-mesenchymal transition (EMT)-associated migration invasion cells. The purpose present study was reveal potential anticancer effects hepatocellular carcinoma (HCC) cells, EMT. MTT assay used determine cell viability. Migration were evaluated through wound healing...

Hepatocellular carcinoma (HCC), the sixth most common malignancy worldwide, is characterized by a dismal prognosis due to high recurrence and metastasis rates. Thus, need for development of novel chemotherapeutic drugs urgent. Cyclovirobuxine D (CVB-D), steroidal alkaloid extracted from Buxus microphylla that has been extensively used relieve symptoms cardiovascular diseases, shown promising antineoplastic effects in recent studies. However, therapeutic underlying mechanisms CVB-D on HCC...

Calcium oxalate (CaOx) crystals can activate inflammatory cytokines by triggering inflammasomes, which cause damage to the adhered epithelium, a dysfunctional microenvironment and even renal failure. However, comprehensive in-depth understanding of mechanisms underlying effects these on cytokine function in tubular epithelial cells (TECs) remains limited be explored.We detected pyroptosis TECs induced after exposure CaOx demonstrated significance activation subsequent processes through...

Malignant gliomas are a group of aggressive neoplasms among human cancers. The curative effects current treatments finite for improving the prognosis patients. Hyperthermia (HT) is an effective treatment cancers; however, HT with different temperatures in MG and relevant mechanisms remain unclear. MTT assay Annexin V‑fluorescein isothiocyanate/propidium iodide staining were used investigating proliferation apoptosis C6 cells, respectively. Western blotting was applied to detect expression...

Fangchinoline (FAN), an alkaloid extracted from Stephania tetrandra, has a variety of biological and pharmacological activities, but evidence its effects on colon adenocarcinoma (COAD) is limited. Therefore, the present study aimed to elucidate molecular mechanisms by which FAN affects COAD. The cytotoxicity, viability proliferation DLD‑1 LoVo cells were assessed in presence using MTT colony formation assays. apoptosis cell cycle COAD analysed flow cytometry, migration invasion these wound...

BaTiO 3 –TiO 2 hollow spheres were synthesized for efficient MWDT in cancer treatment, enabling precise tumor elimination with minimal damage to healthy tissues by enhancing production of ROSs upon microwave triggering.

The aim of the present study was to investigate effect Forkhead family transcription factor P3 (Foxp3) knockdown on function cluster differentiation (CD)4+CD25+ regulatory T cell (Tregs) and tumor growth a hepatocellular carcinoma (HCC) mouse model. CD4+CD25+ Tregs CD4+CD25- cells were sorted from peripheral blood mononuclear (PBMCs) patients with HCC. Then, ultrasound-targeted microbubble destruction (UTMD)-mediated Foxp3-microRNA (miRNA) transfected into Tregs. Subsequently, co-cultured...

Purpose Seismic isolation, as an effective risk mitigation strategy of building/bridge structures, is incorporated into AP1000 nuclear power plants (NPPs) to alleviate the seismic damage that may occur traditional structures NPPs during their service. This promote passive safety concept in structural design against earthquakes. Design/methodology/approach In conjunction with tuned-mass-damping (TMD) integrated resistance system satisfy multi-functional purposes. The proposed...

A surface porous morphology and PtO_x payload synergistically induced an enhancement of the <italic>r</italic>₁ value to 20.48 mM⁻¹ s⁻¹ in a Mn₃O₄/PtO_x nanocomposite for MR imaging.