A5006007052- Neuroinflammation and Neurodegeneration Mechanisms
- IL-33, ST2, and ILC Pathways
- Immune Cell Function and Interaction
- Probiotics and Fermented Foods
- Gut microbiota and health
- S100 Proteins and Annexins
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Ubiquitin and proteasome pathways
- Glioma Diagnosis and Treatment
- Cell Adhesion Molecules Research
- T-cell and B-cell Immunology
- Retinal Diseases and Treatments
- Endoplasmic Reticulum Stress and Disease
- Apelin-related biomedical research
- Seaweed-derived Bioactive Compounds
- Barrier Structure and Function Studies
- Alzheimer's disease research and treatments
- Renin-Angiotensin System Studies
- Inflammatory mediators and NSAID effects
- Complement system in diseases
- Ferroptosis and cancer prognosis
- Cellular transport and secretion
- Nanoplatforms for cancer theranostics
- Immune Response and Inflammation
- Peptidase Inhibition and Analysis
Fudan University
2017-2024
State Key Laboratory of Medical Neurobiology
2017-2024
Kyoto University
2019-2022
Harbin Medical University
2019
First Affiliated Hospital of Harbin Medical University
2019
Jiangnan University
2017
China Agricultural University
2013-2016
Neovascularization and vascular remodeling are functionally important for brain repair after stroke. We show that neutrophils accumulate in the peri-infarct cortex during all stages of ischemic Neutrophils producing intravascular intraparenchymal neutrophil extracellular traps (NETs) peak at 3-5 days. Neutrophil depletion reduces blood-brain barrier (BBB) breakdown enhances neovascularization 14 Peptidylarginine deiminase 4 (PAD4), an enzyme essential NET formation, is upregulated...
Abstract Intracerebral hemorrhage associated with thrombolytic therapy tissue plasminogen activator (tPA) in acute ischemic stroke continues to present a major clinical problem. Here, we report that infusion of tPA resulted significant increase markers neutrophil extracellular traps (NETs) the cortex and plasma mice subjected photothrombotic middle cerebral artery occlusion. Peptidylarginine deiminase 4 (PAD4), critical enzyme for NET formation, is also significantly upregulated brains...
Blood–brain barrier (BBB) breakdown and inflammation occurring at the BBB have a key, mainly deleterious role in pathophysiology of ischemic stroke. Neddylation is ubiquitylation-like pathway that critical various cellular functions by conjugating neuronal precursor cell-expressed developmentally down-regulated protein 8 (NEDD8) to target proteins. However, roles neddylation stroke remain elusive. Here, we report NEDD8 conjugation increased during acute phase after was present intravascular...
Invariant natural killer T (iNKT) cells are a group of innate-like lymphocytes that recognize lipid antigens. They supposed to be tissue resident and important for systemic local immune regulation. To investigate the heterogeneity iNKT cells, we recharacterized in thymus peripheral tissues. were divided into three subpopulations by expression cell receptor CD244 chemokine CXCR6 designated as C0 (CD244-CXCR6-), C1 (CD244-CXCR6+), or C2 (CD244+CXCR6+) cells. The development maturation from...
Glioblastoma multiforme (GBM) has been considered the most aggressive glioma type.Temozolomide (TMZ) is main first-line chemotherapeutic agent for GBM.Decreased mutS homolog 6 (MSH6) expression clinically recognized as one of principal reasons GBM resistance to TMZ.However, specific functions MSH6 in GBM, addition its role mismatch repair, remain unknown.Methods: Bioinformatics were employed analyze mRNA and protein levels clinical samples predict potential cancer-promoting mechanisms...
Blood-brain barrier (BBB) defects and cerebrovascular dysfunction contribute to amyloid-β (Aβ) brain accumulation drive Alzheimer disease (AD) pathology. By regulating vascular functions inflammation in the microvasculature, a disintegrin metalloprotease with thrombospondin type I motif, member 13 (ADAMTS13) plays significant protective effect atherosclerosis stroke. However, whether ADAMTS13 influences AD pathogenesis remains unclear. Using vivo multiphoton microscopy, histological,...
Interleukin-15 (IL-15) is a cytokine critical for maintenance of intestinal intra-epithelial lymphocytes (IELs), especially CD8αα + IELs (CD8αα IELs). In the intestine, IL-15 produced by epithelial cells (IECs), blood vascular endothelial (BECs) and hematopoietic cells. However, precise role on still unknown. To address question, we generated two kinds conditional knockout (IL-15cKO) mice: villin-Cre (Vil-Cre) Tie2-Cre IL-15cKO mice. IEC-derived was specifically deleted in Vil-Cre mice,...
BACKGROUND: Ischemic stroke is often accompanied by oxidative stress and inflammatory response, both of which work synergistically to exacerbate the disruption blood-brain barrier ischemic brain injury. ALK (anaplastic lymphoma kinase), a cancer-associated receptor tyrosine kinase, was found play role in inflammation. In this study, we investigated inhibition murine model stroke. METHODS: Focal cerebral ischemia induced temporary occlusion right middle artery mice with filament. The...
T cell development and homeostasis requires IL-7R α-chain (IL-7Rα) signaling. Tyrosine Y449 of the IL-7Rα is essential to activate STAT5 PI3K, whereas PI3K recruitment methionine M452. How activates regulates both signaling pathways differentially remains unclear. To characterize differential signaling, we established two lines mutant mice: IL-7R-Y449F mice IL-7R-M452L mice. showed decreased signals, but significantly increased owing a competition between through IL-7Rα. The number T, B,...
A probiotic strain Lactobacillus paracasei L9,which was isolated from human intestine, investigated for its immunomodulatory activity in vivo. Results showed that L9 improved systemic immunity by enhancing the phagocytic of peritoneal macrophages, proliferation ratio splenocytes, IgG level serum and IgA mucosa. Further, L9induced theTh1-polarized immune response elevating IFN-?/IL-4 This effect confirmed enhanced IL-12-inducing macrophages after vitro stimulation L9. Also detected increased...
Abstract Neddylation is a ubiquitylation-like pathway that critical in various cellular functions by conjugating NEDD8 to target proteins. However, the roles of neddylation stroke, remain elusive. Here, we report conjugation increased after ischemic stroke and was abundantly present neutrophils, whereas cullin-1, key substrate neddylation, upregulated endothelium. Inhibition MLN4924, inactivated cullin-RING E3 ligase (CRL), reduced brain infarction improved functional outcomes. MLN4924...