A5101478419- Microbial Community Ecology and Physiology
- Food Allergy and Anaphylaxis Research
- Plant Gene Expression Analysis
- Gut microbiota and health
- Probiotics and Fermented Foods
- Protein Hydrolysis and Bioactive Peptides
- Genomics and Phylogenetic Studies
- Plant Molecular Biology Research
- Glycosylation and Glycoproteins Research
- Bacteriophages and microbial interactions
- Fungal Biology and Applications
- Plant Virus Research Studies
- Biological and pharmacological studies of plants
- Plant Pathogens and Fungal Diseases
- Monoclonal and Polyclonal Antibodies Research
- vaccines and immunoinformatics approaches
- Reproductive Biology and Fertility
- Cancer-related molecular mechanisms research
- Aquaculture disease management and microbiota
- Microbial Metabolism and Applications
- Microbial Metabolites in Food Biotechnology
- Infant Nutrition and Health
- Pharmacological Effects of Natural Compounds
- Marine and coastal ecosystems
- Heme Oxygenase-1 and Carbon Monoxide
Chinese Academy of Medical Sciences & Peking Union Medical College
2016-2024
Second Affiliated Hospital of Zhejiang University
2020-2024
Anhui Medical University
2022-2024
Second Hospital of Anhui Medical University
2022-2024
Zhejiang Chinese Medical University
2022-2024
Ministry of Agriculture and Rural Affairs
2019-2023
Chinese Academy of Agricultural Sciences
2019-2023
Institute of Food Science and Technology
2019-2023
Institute of Medical Biology
2023
Cardiff University
2022
The SAR11 Alphaproteobacteria are the most abundant heterotrophs in oceans and believed to play a major role mineralizing marine dissolved organic carbon. Their genomes among smallest known for free-living heterotrophic cells, raising questions about how they successfully utilize complex matter with limited metabolic repertoire. Here we show that conserved genes subgroup Ia (Candidatus Pelagibacter ubique) encode pathways oxidation of variety one-carbon compounds methyl functional groups...
In recent years, a lot of efforts have been made in conformational epitope prediction as antigen proteins usually bind antibodies with an assembly sequentially discontinuous and structurally compact surface residues. Currently, only few methods for spatial are available focus on single residue propensity scales or continual segments clustering. the method SEPPA, concept ‘unit patch triangle’ was introduced to better describe local context protein surface. Besides that, SEPPA incorporated...
Rheumatoid arthritis, a chronic autoimmune disease, is characterized by synovial hyperplasia and cartilage erosion. Here, we investigated the potential mechanism of action quercetin, main component flavonoids, in treating rheumatoid arthritis.
In Magnaporthe oryzae, pyriform conidia are the primary inoculum and main source for disease dissemination in field. this study, we identified characterized COM1 gene that was disrupted three insertional mutants producing slender conidia. encodes a putative transcription regulator unique to filamentous ascomycetes. The com1 disruption deletion had similar defects conidium morphology were significantly reduced virulence on rice barley seedlings. Microscopic examination revealed Δcom1...
Summary The Pelagibacterales order (SAR11) in Alphaproteobacteria dominates marine surface bacterioplankton communities, where it plays a key role carbon and nutrient cycling. SAR11 phages, known as pelagiphages, are among the most abundant phages ocean. Four pelagiphages that infect Pelagibacter HTCC1062 have been reported. Here, we report 11 new Podoviridae family. Comparative genomics classified these into HTVC019Pvirus genus, which includes previously reported HTVC011P HTVC019P....
Abstract Dendrobium is known for its pharmacological actions including anti-cancer effect, anti-fatigue gastric ulcer protective and so on. At present, only studies on endophytic fungi of affecting the metabolites host plants have been reported, very little research has done bacteria. In this study, we demonstrated great diversity bacteria in 6 samples from different origins cultivars. According to results culture-independent method, bacterial community stems showed obvious was influenced by...
The present study examines the effect of polyphenols extract adlay (Coix lachryma-jobi L. var. ma-yuen Stapf) (APE) on high cholesterol diet fed rats (HCD). APE was orally administrated by gavage at doses 10, 40 and 200 mg total phenolics/kg body weight once a day for 28 days. At end four weeks, serum triglyceride (TG), (TC), low density lipoprotein (LDL-C) (HDL-C), markers oxidative stress viz., malondialdehyde (MDA), superoxide dismutase (SOD), catalase (CAT) glutathione peroxidase...
The goal of this study was to characterize the function microRNA-27a-3p (miR-27a-3p) in polycystic ovary syndrome (PCOS). miR-27a-3p expression analyzed excised granulosa cells (GCs) from 21 patients with PCOS and 12 normal undergoing vitro fertilization cycle treatments 17 nontreated cuneiform ovarian resection samples 13 control without PCOS. We found that significantly increased both GCs ovaries compared controls. Insulin treatment human granulosa-like tumor cell line (KGN) resulted...
Cow milk (CM) allergy is one of the most common food allergies worldwide; abundant CM proteins, such as casein (CN), β-lactoglobulin (β-LG), and ɑ-lactalbumin (ɑ-LA), are all potentially allergenic. Reducing antigenicity continues to be a major challenge. However, previous studies have focused on individual allergic proteins. Thus, in present study, we aimed evaluate effects different food-grade enzymes CN, β-LG, ɑ-LA natural CM. The degree hydrolysis (DH) molecular mass (MW) distribution...
Cow milk (CM) allergy is a worldwide concern. Currently, few studies have been performed on the immunoreactivity of CM and fewer still antigenicity in vivo vitro. In this study, we assessed potential allergenicity enzymatically hydrolyzed using vitro ELISA oral sensitization challenge BALB/c mice. Alcalase-, Protamex-, Flavourzyme-treated (all from Novozymes) diminished IgE binding capacity, with greatest reductions 56.31%, 50.62%, 56.45%, respectively. Allergic symptoms levels total IgG
Dietary flaxseed (FS) is a nutritional whole grain with high contents of omega-3 fatty acids and lignans anti-inflammatory antioxidant properties. We evaluated FS in murine model pulmonary ischemia-reperfusion injury (IRI) by dietary supplementation 0% (control) or 10% (treatment) before IRI. Mice fed undergoing IRI had significant decrease arterial oxygenation (Pa(O(2))) increase bronchoalveolar lavage (BAL) protein compared sham-operated mice. However, mice improvement both Pa(O(2)) BAL In...
Many major marine bacterial lineages such as SAR11, Prochlorococcus, SAR116, and several Roseobacter have members that are abundant, relatively slow-growing, genome streamlined. The isolation of phages infect SAR11 SAR116 demonstrated the dominance these in virosphere. However, no been isolated from bacteria RCA lineage, another abundant group bacteria. In this study, seven three different strains were characterized. All belong to Podoviridae family sizes ranging 39.6 58.1 kb. Interestingly,...