A5054574187- T-cell and B-cell Immunology
- Immunotherapy and Immune Responses
- Immune Cell Function and Interaction
- High voltage insulation and dielectric phenomena
- CAR-T cell therapy research
- Advancements in Semiconductor Devices and Circuit Design
- vaccines and immunoinformatics approaches
- Cancer Immunotherapy and Biomarkers
- Semiconductor materials and devices
- Electrostatic Discharge in Electronics
- Immune Response and Inflammation
- Plasma Diagnostics and Applications
- Pancreatic and Hepatic Oncology Research
- Plasma Applications and Diagnostics
- Ocular Surface and Contact Lens
- Colorectal Cancer Treatments and Studies
- Silicon Carbide Semiconductor Technologies
- Power Transformer Diagnostics and Insulation
- Immunodeficiency and Autoimmune Disorders
- Systemic Lupus Erythematosus Research
- Aerosol Filtration and Electrostatic Precipitation
- Diabetes and associated disorders
- Cancer therapeutics and mechanisms
- Integrated Circuits and Semiconductor Failure Analysis
- Atrial Fibrillation Management and Outcomes
Icahn School of Medicine at Mount Sinai
2016-2025
National Defense Medical College
2008-2025
Kyoto University
1999-2025
National Cancer Center
2015-2025
University of Hyogo
2009-2024
RIKEN
2003-2024
Pioneer (Japan)
2024
RIKEN Nishina Center
2008-2024
Baylor University
2009-2021
Kyoto Prefectural University of Medicine
2021
A T cell subset that emerges in blood after seasonal influenza vaccinations correlates with the development of protective antibody responses.
Abstract Small, soluble metabolites not only are essential intermediates in intracellular biochemical processes, but can also influence neighbouring cells when released into the extracellular milieu 1–3 . Here we identify metabolite and neurotransmitter GABA as a candidate signalling molecule synthesized secreted by activated B plasma cells. We show that cell-derived promotes monocyte differentiation anti-inflammatory macrophages secrete interleukin-10 inhibit CD8 + T cell killer function....
Tertiary lymphoid structures (TLS) are transient ectopic aggregates whose formation might be caused by chronic inflammation states, such as cancer. However, how TLS induced in the tumor microenvironment (TME) and they affect patient survival not well understood. We investigated distribution relation to infiltrating lymphocytes (TILs) related gene expression high-grade serous ovarian cancer (HGSC) specimens. CXCL13 correlated with presence infiltration of T cells B cells, it was a favorable...
Dendritic cells (DCs) loaded with killed allogeneic tumors can cross-prime tumor-specific naive CD8 T in vitro, thereby providing an option to overcome human leukocyte antigen restriction inherent loading DC vaccines peptides. We have vaccinated 20 patients stage IV melanoma autologous monocyte-derived DCs Colo829 cell line. were generated by culturing monocytes granulocyte macrophage-colony stimulating factor (granulocyte factor) and interleukin (IL-4) activated additional culture tumor...
Although it is accepted that regulatory T cells (T regs) contribute to cancer progression, most studies in the field consider nonantigen-specific suppression. Here, we show presence of tumor antigen-specific CD4(+) regs blood patients with metastatic melanoma. These recognize a broad range antigens, including gp100 and TRP1 (melanoma tissue differentiation antigens), NY-ESO-1 (cancer/testis antigen) survivin (inhibitor apoptosis protein (IAP) family antigen). proliferate peripheral...
Abstract The immune mechanism leading to the generation of protective antibody responses following influenza trivalent inactivated vaccine (TIV) vaccinations remains largely uncharacterized. We recently reported that TIV vaccination induced a transient increase circulating ICOS + PD-1 CXCR3 T follicular helper (cTfh) cells in blood, which positively correlated with induction measured at day 28. However, whether and how these directly contribute response unclear. In this study, we analyzed...
Key Points IL-12Rβ1–deficient subjects displayed substantially less circulating memory Tfh and B cells than control subjects. The IL-12–STAT4 axis is associated with the development functions of in vivo humans.