A5056713408- Platelet Disorders and Treatments
- Immunodeficiency and Autoimmune Disorders
- Blood groups and transfusion
- Chronic Lymphocytic Leukemia Research
- Systemic Lupus Erythematosus Research
- Blood disorders and treatments
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Renal Diseases and Glomerulopathies
- Autoimmune Bullous Skin Diseases
- Immune Cell Function and Interaction
- Eosinophilic Disorders and Syndromes
- T-cell and B-cell Immunology
- Vasculitis and related conditions
- Pneumocystis jirovecii pneumonia detection and treatment
- Cell Adhesion Molecules Research
- Acute Myeloid Leukemia Research
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Sarcoidosis and Beryllium Toxicity Research
- HIV-related health complications and treatments
- Autoimmune and Inflammatory Disorders
- Urticaria and Related Conditions
- Blood properties and coagulation
- Liver Diseases and Immunity
- Otitis Media and Relapsing Polychondritis
- Hepatitis C virus research
Hôpital Cardiologique du Haut-Lévêque
2016-2025
Université de Bordeaux
2016-2025
Inserm
2015-2025
Centre Hospitalier Universitaire de Bordeaux
2015-2024
Bordeaux Population Health
2015-2024
Centre National de la Recherche Scientifique
1993-2024
Immunology from Concept and Experiments to Translation
2024
Hôpital d'Hautepierre
2023
Sorbonne Université
2023
Université de Montpellier
2020-2023
Common variable immunodeficiency is characterized by recurrent infections and defective immunoglobulin production.The DEFI French national study prospectively enrolled adult patients with primary hypogammaglobulinemia. Clinical events before inclusion were retrospectively analyzed at that time.From April 2004 through 2007, 341 enrolled, 252 of whom had received a diagnosis common immunodeficiency; those, 110 male, 142 female, 228 white. The median age first symptoms was 19 years. 33.9 delay...
OBJECTIVES: The enteropathy associated with common variable immunodeficiency (CVID) is poorly characterized, and its possible relationships well-defined causes of enteropathy, such as celiac sprue (CS), remain debated. We aimed to assess the clinical histopathological features CVID. METHODS: medical files 50 CVID patients gastrointestinal symptoms were analyzed retrospectively. Histological, phenotypic, molecular analysis intestinal endoscopic specimens was centrally performed. RESULTS:...
Summary Romiplostim was effective, safe, and well‐tolerated over 6–12 months of continuous treatment in Phase 3 trials patients with immune thrombocytopenia ( ITP ). This report describes up to 5 years weekly romiplostim 292 adult a long‐term, single‐arm, open‐label study. Outcome measures included adverse events (including bleeding, thrombosis, malignancy, reticulin/fibrosis), platelet response (platelet count >50 × 10 9 per litre), the proportion requiring rescue treatments....
We investigated the production of IL-2, IFN-gamma, IL-10 and IL-4 by PBMC from 24 patients with SLE 10 healthy individuals. Basal mitogen-stimulated (lipopolysaccharide phytohaemagglutinin (LPS + PHA)) cytokine was determined in a whole blood assay (WBA). Supernatants were collected assayed specific ELISAs. Although IL-2 IFN-gamma contents did not differ significantly between controls under both conditions, statistically significant correlations found each disease activity (SLAM index) after...
Common variable immunodeficiency (CVID) is a primary immune deficiency defined by defective antibody production. In most series, small proportion of patients present with opportunistic infections (OIs).The French DEFI study has enrolled hypogammaglobulinemia and allows detailed clinical immunologic description previous OIs and/or at risk for OIs.Among 313 CVID, 28 (8.9%) presented late-onset combined (LOCID), the occurrence an OI CD4(+) T cell count <200 x 10(6) cells/L, were compared...
An algorithm for the detection of pulmonary arterial hypertension (PAH), based on presence dyspnea and findings Doppler echocardiographic evaluation velocity tricuspid regurgitation (VTR) right-sided heart catheterization (RHC), which was applied in a large multicenter systemic sclerosis (SSc) population, estimated prevalence PAH to be 7.85%. The aim this observational study investigate incidence (PH) during 3-year followup patients from same cohort (the ItinérAIR-Sclérodermie...
Summary In anecdotal reports, some patients with immune thrombocytopenia ( ITP ) maintained platelet counts after discontinuing romiplostim. Here, we examined rates of response (≥50 × 10 9 /l), remission , splenectomy and adverse events in primary duration ≤6 months who were treated romiplostim for ≤12 months. The starting dose was 1 μg/kg; concomitant rescue treatments permitted to maintain counts. Patients ≥50 /l at the end 12 entered a taper which decreased as long maintained. Remission...
Summary Patients with common variable immunodeficiency (CVID) are at high risk of developing immune thrombocytopenia (ITP) and/or autoimmune haemolytic anaemia (AHA). Given their underlying immunodeficiency, immunosuppressive treatment these manifestations may increase the infection. To assess efficacy and safety rituximab in patients CVID‐associated ITP/AHA, a multicentre retrospective study was performed. Thirty‐three patients, 29 adults four children, were included. received an average...
Abstract Objectives The aim of this study was to investigate whether the quadrivalent human papillomavirus ( HPV ) vaccine Gardasil is associated with a change in risk autoimmune disorders AD s) young female subjects. Design Systematic case–control incident s vaccination women across France. Participants and setting A total 113 specialised centres recruited (from December 2007 April 2011) females aged 14–26 years cases six types s: idiopathic thrombocytopenic purpura ITP ), central...
Objective Findings from the WEGENT trial and other short‐term studies have suggested that azathioprine (AZA) or methotrexate (MTX) could effectively maintain remission of granulomatosis with polyangiitis (Wegener's) (GPA) microscopic (MPA). This study was undertaken to examine whether differences in rates relapse adverse events would appear after discontinuation these 2 maintenance regimens, when assessed over a longer followup period. Methods Long‐term outcomes patients enrolled were...
Abstract Autoimmunity can occur when a checkpoint of self-tolerance fails. The study familial autoimmune diseases reveal pathophysiological mechanisms involved in more common diseases. Here, by whole-exome/genome sequencing we identify heterozygous, autosomal-dominant, germline loss-of-function mutations the SOCS1 gene ten patients from five unrelated families with early onset manifestations. intracellular protein is known to downregulate cytokine signaling inhibiting JAK-STAT pathway....
Thrombopoietin receptor agonists (TPOra) are the only treatments for immune thrombocytopenia (ITP) which evidence of efficacy and safety from randomized, placebo-controlled trials is available. We sought to determine long-term tolerability TPOra romiplostim, with a particular focus on thrombosis, bleeding, bone marrow (BM) reticulin, neoplasms/haematological malignancies fatal events.
Background. Good syndrome (GS) is a rare condition in which thymoma associated with hypogammaglobulinemia. It characterized by increased susceptibility to bacterial, viral, and fungal infections, as well autoimmunity. Most patients have no circulating B cells.