A5012313374- Immune Cell Function and Interaction
- T-cell and B-cell Immunology
- Cytomegalovirus and herpesvirus research
- Renal and Vascular Pathologies
- Cytokine Signaling Pathways and Interactions
- Cell death mechanisms and regulation
- Renal Transplantation Outcomes and Treatments
- Systemic Lupus Erythematosus Research
- Phagocytosis and Immune Regulation
- Immune Response and Inflammation
- Immunodeficiency and Autoimmune Disorders
- Immunotherapy and Immune Responses
- Cultural Heritage Materials Analysis
- HIV Research and Treatment
- MRI in cancer diagnosis
- RNA Interference and Gene Delivery
- Pediatric Urology and Nephrology Studies
- Renal cell carcinoma treatment
- Archaeology and ancient environmental studies
- Monoclonal and Polyclonal Antibodies Research
- Complement system in diseases
- Asthma and respiratory diseases
- Advanced MRI Techniques and Applications
- Renal Diseases and Glomerulopathies
- CAR-T cell therapy research
Immunology from Concept and Experiments to Translation
2005-2024
Centre National de la Recherche Scientifique
2012-2024
Université de Bordeaux
2011-2023
Bordeaux Population Health
2015-2021
Centre Hospitalier Universitaire de Bordeaux
2008-2019
Délégation Paris 5
2018-2019
Université Paris Cité
2018-2019
Université du Québec à Chicoutimi
1996-2017
Hôpital Pellegrin
2005-2016
Biotherapy of Genetic Diseases, Inflammatory Disorders and Cancers
2003-2015
Abstract PGE2 is a well-known immunomodulator produced in the immune response by APCs, such as dendritic cells (DCs), most potent APC of system. We investigated biosynthetic capacity bone marrow-derived DC (BM-DC) and effects PG on APC. observed that BM-DC produce other proinflammatory mediators, leukotriene B4 NO, after LPS exposure. Constitutively present BM-DC, cyclooxygenase (COX)-1 did not contribute significantly to total pool compared with LPS-induced COX-2-produced PGE2. Treatment...
In normal individuals, γδ T cells account for less than 6% of total peripheral lymphocytes and mainly express T-cell receptor (TCR) Vδ2-Vγ9 chains. We have previously observed a dramatic expansion in the blood renal allograft recipients only when they developed cytomegalovirus (CMV) infection. This increase was long lasting (more 1 year), associated with an activation cells, concerned Vδ1 or Vδ3 subpopulations. Analysis TCR junctional diversity revealed that CMV infection these patients...
Abstract Objective Cytotoxic T lymphocyte–mediated killing using granzyme B has recently been proposed to be a preferential and selective source of autoantigens in systemic autoimmune diseases, including lupus erythematosus (SLE), while other reports have indicated that cytolytic activity SLE patients was decreased. The aim this study examine the phenotypic functional status CD8+ cells patients. Methods Phenotype analysis carried out flow cytometry. cytotoxic potential its consequences were...
We investigated the production of IL-2, IFN-gamma, IL-10 and IL-4 by PBMC from 24 patients with SLE 10 healthy individuals. Basal mitogen-stimulated (lipopolysaccharide phytohaemagglutinin (LPS + PHA)) cytokine was determined in a whole blood assay (WBA). Supernatants were collected assayed specific ELISAs. Although IL-2 IFN-gamma contents did not differ significantly between controls under both conditions, statistically significant correlations found each disease activity (SLAM index) after...
Long-lasting expansion of Vdelta2(neg) gammadelta T cells is a hallmark cytomegalovirus (CMV) infection in kidney transplant recipients. The ligands these and their role remain elusive. To better understand immune function, we generated cell clones from several transplanted patients. Numerous patient Vdelta1(+), Vdelta3(+), Vdelta5(+) expressing diverse Vgamma chains, but not control Vgamma9Vdelta2(+) clones, displayed strong reactivity against CMV-infected cells, as shown by production...
In the autoimmune disease lupus, platelets activated by self-antigens contribute to pathology triggering secretion of interferon from immune cells.
Unusual fat-containing renal tumors in a series of 27 cases comprised five categories: atypical and complicated angiomyolipomas (AMLs) (n = 15), including AMLs with extrarenal growth 5), undetectable fat 4), hemorrhagic 6); cell carcinomas (RCCs) 9); lipoma 1); liposarcoma oncocytoma 1). Fat was present within RCCs by the following mechanisms; lipid-producing necrosis large RCC 2), intratumoral bone metaplasia fatty marrow elements calcification small entrapment perirenal 4) or sinus 1)...
Significance Human γδ T lymphocytes have innate-like and adaptive-like functions can circulate in blood or reside tissues. They are activated by specific antigens recognized their T-cell receptor recognize infected transformed cells, suggesting that cellular stress is involved antigen expression. However, molecular characterization of stress-induced remains elusive, hampering our understanding the role cells cancer infections. In present study we identify annexin A2 as such known a...
In normal persons, circulating γδ T cells comprise a minor cell subset (0.5%–6% of total lymphocytes). were studied in the context therapeutic immunosuppression transplanted patients. Flow cytometry detected an expansion 31 205 renal allograft recipients and 2 41 uremic patients but none 45 healthy subjects. Univariate statistical analysis identified cytomegalovirus (CMV) infection (P < .001), second graft antithymocyte globulin treatment = .01) as three variables associated with high levels...
γδ T cells undergo massive expansion in the peripheral blood of renal transplant recipients who are infected with cytomegalovirus (CMV). In a 3-year prospective study, relationship between evolution CMV infection and kinetics cell amplification was followed for 10 months after transplantation. Patients late (⩾45 days) had significantly longer (P<.0001) higher (P<.0003) pp65 antigenemia more-symptomatic disease than did patients early expansion. Analysis data each patient showed that is...
It is widely believed that demonstration of fat within a well-marginated renal tumor at computed tomography (CT) highly suggestive angiomyolipoma and can rule out cell carcinoma. The authors describe patient in whom CT demonstrated solid mass containing calcifications small amounts fat. Renal carcinoma was diagnosed pathologic examination. had tubular papillary architectural configurations associated with areas osseous metaplasia located the fibrous stroma tumor. should be considered...
Abstract Objective Recent studies have revealed a potential implication of CD8+ T lymphocytes in the pathogenesis systemic lupus erythematosus (SLE) through their ability to induce tissue damage. The aim present study was analyze localization cells kidneys patients with class III and IV nephritis establish correlations histologic, biologic, clinical features SLE. Methods Twenty‐five consecutive SLE or were enrolled. Phenotype analyses blood renal immunohistochemistry performed. Results...
Renal biopsies were performed in 211 patients which 10 days of excretory urography or renal arteriogrpahy diatrizoate, iothalamate ioxithalamate had been used. In 47 specimens, osmotic nephrosis the proximal tubular cells was found. Previous function normal patients, moderately impaired 19, and severely 18. Tubular atrophy and/or necrosis associated with histological features 29 patients. Diffuse more often found biopsied soon after roentgenography also severe insufficiency, but not...