A5018718380- T-cell and B-cell Immunology
- Systemic Lupus Erythematosus Research
- Immune Cell Function and Interaction
- Graphene and Nanomaterials Applications
- Monoclonal and Polyclonal Antibodies Research
- Cell Adhesion Molecules Research
- Salivary Gland Disorders and Functions
- Chemokine receptors and signaling
- Immunotherapy and Immune Responses
- Carbon Nanotubes in Composites
- Nanoparticles: synthesis and applications
- RNA and protein synthesis mechanisms
- Carbon and Quantum Dots Applications
- IL-33, ST2, and ILC Pathways
- Cytokine Signaling Pathways and Interactions
- Diabetes and associated disorders
- Cancer Immunotherapy and Biomarkers
- interferon and immune responses
- Nanoplatforms for cancer theranostics
- Chemical Synthesis and Analysis
- Protease and Inhibitor Mechanisms
- Antimicrobial Peptides and Activities
- Glycosylation and Glycoproteins Research
- RNA Research and Splicing
- Atherosclerosis and Cardiovascular Diseases
Institut de Biologie Moléculaire et Cellulaire
2015-2025
Centre National de la Recherche Scientifique
2013-2025
Immunologie, Immunopathologie et Chimie Thérapeutique
2011-2024
Université de Strasbourg
2001-2021
Société de Réanimation de Langue Française
2021
University of Puerto Rico at Carolina
2019
University of Trieste
2008
Institut de Biologie Moléculaire des Plantes
1996-2007
Institute of Haematology and Blood Transfusion
2005
Weatherford College
1995
Graphene oxide (GO) is attracting an ever-growing interest in different fields and applications. Not much known about the possible impact of GO sheet lateral dimensions on their effects vitro, especially human primary cells. In attempt to address this issue, we present a study evaluate, how highly soluble 2-dimensional constituted large or small flakes affects monocyte derived macrophages (hMDM). For purpose, size was tuned using sonication three samples were obtained. The non sonicated one...
Follicular helper T cells (TFH) represent a distinct subset of CD4+ specialized in providing help to B lymphocytes, which may play central role autoimmune diseases having major cell component such as systemic lupus erythematosus. Recently, TFH subsets that share common phenotypic and functional characteristics with from germinal centers, have been described the peripheral blood healthy individuals. The aim this study was analyze distribution populations patients. Circulating were defined by...
Abstract The fate of naive CD8+ T cells is determined by the environment in which they encounter MHC class I presented peptide Ags. manner tumor Ags are a longstanding matter debate. Ag presentation might be mediated draining lymph nodes or via cross-presentation professional APC. Either pathway insufficient to elicit protective antitumor immunity. We now demonstrate using syngeneic mouse model, expressing an derived from early region 1A human adenovirus type 5, that inadequate nature CTL...
Abstract Inherent immune suppression represents a major challenge in the treatment of human cancer. The extracellular matrix molecule tenascin-C promotes cancer by multiple mechanisms, yet roles tumor immunity are incompletely understood. Using 4NQO-induced oral squamous cell carcinoma (OSCC) model with abundant and absent tenascin-C, we demonstrated that enforced an immune-suppressive lymphoid stroma via CCL21/CCR7 signaling, leading to increased metastatic tumors. Through TLR4, expression...
Aim: Different studies, carried out by us and others, have investigated the impact of carbon nanotubes (CNTs) in vitro animal models. To date, only a few studies been performed on human cells ex vivo. There is also lack comparison between CNTs with varied functionalization structural properties their different cell types. Materials & Methods: The present vivo study focuses series functionalized multiwalled T B lymphocytes, natural killer (NK) monocytes. Results: Smaller diameter are...
Water-soluble carbon nanotubes functionalized with cell-adhesion peptides do not affect the viability of different cell types, including Jurkat cells, splenocytes, and neurons. They also modify neuronal morphology basic functions, thus representing a promising candidate for exploitation novel drug-delivery systems or designing new generation self-assembling nerve bridges. Detailed facts importance to specialist readers are published as "Supporting Information". Such documents peer-reviewed,...
Systemic lupus erythematosus (SLE) is a systemic autoimmune disease characterized by loss of tolerance toward self-nucleic acids, autoantibody production, interferon expression and signaling, defect in the regulatory T (T reg ) cell compartment. In this work, we identified that platelets from patients with active SLE preferentially interacted cells via P-selectin/P-selectin glycoprotein ligand-1 (PSGL-1) axis. Selectin interaction PSGL-1 blocked suppressive properties particularly follicular...
Primary Sjögren's syndrome (SS) is the second most frequent systemic autoimmune disease, affecting 0.1% of general population. To characterize molecular and clinical variabilities among patients with primary SS, we integrated transcriptomic, proteomic, cellular, genetic data phenotypes in a cohort 351 SS.We analyzed blood transcriptomes genotypes SS who were participants multicenter prospective cohort. We replicated transcriptome analysis 3 independent cohorts (n = 462 patients). determined...
Humoral responses are central to the development of chronic autoimmune diseases such as systemic lupus erythematosus. Indeed, autoantibody deposition is responsible for tissue damage, kidneys being one main target organs. As source pathogenic antibodies, plasma cells therefore critical players in this harmful scenario, both at and local levels. The aim present study was analyze NZB/W mice get a better understanding mechanisms underlying their involvement renal inflammation process. Using...
Functionalized carbon nanohorns (f-CNH) are uptaken by macrophages, without affecting cell viability. f-CNH induce the production of reactive oxygen species and pro-inflammatory cytokines. The level inflammation, although moderate, should be taken into consideration when using for drug delivery. However, it could exploited as an intrinsic adjuvant function biomedical applications requiring some activation immune system. Supporting information this article is available on WWW under...
Coinhibitory receptors play an important role in the prevention of autoimmune diseases, such as systemic lupus erythematosus (SLE), by limiting T cell activation. B and lymphocyte attenuator (BTLA) is inhibitory receptor, similar to cytotoxic lymphocyte-associated protein 4 (CTLA-4) programmed death 1 (PD1), that negatively regulates immune response. The BTLA pathogenesis diseases humans and, more specifically, SLE largely unknown. We investigated expression on various subsets, we did not...
(NZB × NZW)F1 and MRL/Faslpr lupus mice present a similar phenotype with spectrum of autoantibodies associated very severe nephritis. It is thought, however, that in contrast to other lupus-prone such as mice, do not generate ribonucleoproteins (RNP) Sm/RNP. In this study, we demonstrate contrary previous reports, the autoimmune response directed against Sm/RNP antigens also occurs NZB NZW mice. CD4+ T cells from unprimed 10-week-old proliferate secrete IL-2 peptide 131–151 U1-70K protein,...
Background An important question in dengue pathogenesis is the identity of immune cells involved control virus infection at site mosquito bite. There evidence that immature myeloid dendritic plays a crucial role and interaction viral envelope E glycoprotein with CD209/DC-SIGN key element for their productive infection. Dermal macrophages express CD209, yet little known about Methods Findings Here, we showed dermal bound recombinant fused to green fluorescent protein. Because stain IL-10...
The co-inhibitory receptor B and T Lymphocyte Attenuator (BTLA) negatively regulates cell activation. We have previously shown an altered BTLA expression by regulatory cells impaired capacity of to inhibit CD4+ activation in lupus patients. In this study, we analyzed function the NZB/W lupus-mouse model examined therapeutic potential targeting. were young (10-12-week-old) old-diseased mice (>35-week-old with proteinuria) comparison age-related BALB/W control mice. 20-22 weeks old (n=10)...
An important hallmark of systemic lupus erythematosus is the production autoantibodies specific for nuclear Ags, among which nucleosomes and their constituents, DNA histones. It widely admitted that some these contribute largely in pathogenesis because nephritogenic potential. However, underlying mechanisms are still debated. In this study, we analyzed autoimmune response against histone H2B during course disease lupus-prone (NZBxNZW)F1 mice, both lymphoid organs kidneys, assessed its...
Functionalized carbon nanotubes are increasingly exploited as innovative components for the development of advanced biomedical devices. In this study we report a novel synthetic route formation single-walled nanotube (SWCNT)–polyaniline (PANI) hybrids by in situ chemical polymerization. The surfactant sodium dodecylsulfate (SDS) is used template monomer assembly and resulting composite preserves characterized tight binding between SWCNTs PANI. Having idea integrating these new types SWCNT...