A5075692951- HIV Research and Treatment
- Systemic Lupus Erythematosus Research
- HIV/AIDS drug development and treatment
- Platelet Disorders and Treatments
- HIV-related health complications and treatments
- Immune Cell Function and Interaction
- HIV/AIDS Research and Interventions
- T-cell and B-cell Immunology
- Immunodeficiency and Autoimmune Disorders
- Chronic Lymphocytic Leukemia Research
- Pneumocystis jirovecii pneumonia detection and treatment
- Blood groups and transfusion
- Mycobacterium research and diagnosis
- Hepatitis C virus research
- Eosinophilic Disorders and Syndromes
- Viral-associated cancers and disorders
- Cell Adhesion Molecules Research
- Tuberculosis Research and Epidemiology
- Systemic Sclerosis and Related Diseases
- Cytomegalovirus and herpesvirus research
- Renal Diseases and Glomerulopathies
- Liver Diseases and Immunity
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Polyomavirus and related diseases
- Autoimmune Bullous Skin Diseases
Hôpital Cardiologique du Haut-Lévêque
2010-2023
Université de Bordeaux
2006-2022
Bordeaux Population Health
2018-2022
Immunology from Concept and Experiments to Translation
2020
Centre Hospitalier Universitaire de Bordeaux
2009-2018
Centre de Recherche Inria Bordeaux - Sud-Ouest
2018
General Department of Preventive Medicine
2016
Centre National de la Recherche Scientifique
2002-2015
Hôpital Beau-Séjour
2011
Weatherford College
2010
Objective: To compare mortality rates in combination antiretroviral therapy (cART)-treated HIV-infected adults with the general population according to level of CD4 cell count reached and duration exposure cART. Methods: initiating a protease inhibitor-containing treatment between 1997 1999 were selected Agence Nationale de Recherches sur le Sida et les hépatites virales (ANRS) APROCO AQUITAINE cohorts. counts estimated during follow-up using 2-phase mixed linear model. Standardized ratios...
Abstract Objective Cytotoxic T lymphocyte–mediated killing using granzyme B has recently been proposed to be a preferential and selective source of autoantigens in systemic autoimmune diseases, including lupus erythematosus (SLE), while other reports have indicated that cytolytic activity SLE patients was decreased. The aim this study examine the phenotypic functional status CD8+ cells patients. Methods Phenotype analysis carried out flow cytometry. cytotoxic potential its consequences were...
We investigated the production of IL-2, IFN-gamma, IL-10 and IL-4 by PBMC from 24 patients with SLE 10 healthy individuals. Basal mitogen-stimulated (lipopolysaccharide phytohaemagglutinin (LPS + PHA)) cytokine was determined in a whole blood assay (WBA). Supernatants were collected assayed specific ELISAs. Although IL-2 IFN-gamma contents did not differ significantly between controls under both conditions, statistically significant correlations found each disease activity (SLAM index) after...
In the autoimmune disease lupus, platelets activated by self-antigens contribute to pathology triggering secretion of interferon from immune cells.
Hydroxychloroquine (HCQ) is an important medication for treating systemic lupus erythematosus (SLE). Its blood concentration ([HCQ]) varies widely between patients and a marker predictor of SLE flares. This prospective randomised, double-blind, placebo-controlled, multicentre study sought to compare standard adjusted HCQ dosing schedules that target [HCQ] ≥1000 ng/ml reduce was measured in 573 with (stable disease SELENA-SLEDAI≤12) treated at least 6 months. Patients from 100 750 were...
The present study aimed to determine plasma lipid levels in 95 HIV-infected patients divided into four groups according the CD4 lymphocyte counts comparatively a control group of 20 HIV-negative normolipidaemic subjects. A relationship between lipidic abnormalities and immune or nutritional status was also investigated. below 200 mm-3 (groups 1 2) had significantly lower total cholesterol than controls. 400 lymphocytes 1, 2, 3) higher triglycerides Lp(a) but LDL-cholesterol In all...
Bortezomib is an active agent in AL amyloidosis and responses to this drug combination with cyclophosphamide dexamethasone are both rapid deep. Here we present international, multicenter series of 60 patients Mayo Clinic stage III cardiac assess the impact regimen improving outcomes poor-risk group. The median follow-up for entire cohort 11.8 months. overall response rate was 68%. In a landmark analysis, examining who survived more than 3 months, 86%. A seen 32% patients. estimated 1-year...
Abstract Objective Recent studies have revealed a potential implication of CD8+ T lymphocytes in the pathogenesis systemic lupus erythematosus (SLE) through their ability to induce tissue damage. The aim present study was analyze localization cells kidneys patients with class III and IV nephritis establish correlations histologic, biologic, clinical features SLE. Methods Twenty‐five consecutive SLE or were enrolled. Phenotype analyses blood renal immunohistochemistry performed. Results...
Tregs are impaired in human systemic lupus erythematosus (SLE) and contribute to effector T cell activation. However, the mechanisms responsible for Treg deficiency SLE remain unclear. We hypothesized that OX40L/OX40 axis is implicated regulatory follicular helper (Tfr) dysfunction SLE. engagement on Tfr cells not only specifically their ability regulate proliferation, but also suppress (Tfh) cell-dependent B activation immunoglobulin secretion. Antigen-presenting from patients with active...
AbstractBACKGROUND. Highly active antiretroviral therapies (HAART) in HIV-infected patients are often associated with lipodystrophy syndrome and metabolic disorders. Atherogenic lipid profile could expose these to atheromatous cardiovascular disease. We describe carotid artery intima-media thickness (IMT), a surrogate marker of atherosclerosis, according HIV status, treatment, conventional risk factors. METHOD. In multicenter prospective cohort study we have surveyed subjects IMT measurement...
JC virus (JCV) acts as an opportunistic in immunocompromised human immunodeficiency type 1 (HIV-1)-infected patients. The role of peripheral blood cells central nervous system invasion, before the onset progressive multifocal leukoencephalopathy (PML), remains controversial. In order to clarify JCV latency or reactivation status blood, 72 HIV-1-infected patients were studied, together with 7 HIV-1-positive PML and 50 donors. Blood leukocytes, plasma, B lymphocytes investigated by two...
Assessment of genotypic changes in the reverse transcriptase gene HIV-1 occurring antiretroviral naive patients treated by stavudine plus didanosine combination therapy.Sequence analysis (codons 1-230) was performed after amplification from plasma samples collected at baseline and end treatment 39 previously treatment-naive for 24-48 weeks.At baseline, mutations associated with zidovudine resistance were detected two patients: Asp67Asn/Lys219Gln Leu210Trp. Among subjects, 18 (46%) developed...
The role of antiphospholipid antibodies in the pathogenesis thrombocytopenia observed during primary antibody syndrome (APAS) and systemic lupus erythematosus (SLE) remains controversial. We have used MAIPA test to examine frequency specificity anti‐platelet directed against major platelet membrane glycoproteins (GP IIb–IIIa, GP Ib–IX, Ia–IIa IV) patients where SLE APAS were associated or not with thrombocytopenia. Results compared a series 26 ITP patients, 46% whom shown possess one more...
We evaluated the impact of cytomegalovirus (CMV)–induced immune responses, autoimmune-induced and microbial translocation on activation in 191 human immunodeficiency virus type 1–infected patients from ANRS CO3 Aquitaine Cohort. All enrolled subjects had achieved long-term virological suppression during receipt combination antiretroviral therapy (cART). HLA-DR+/CD38+ expression was 16.8% among CD8+ T cells. Independent age, CD4+ T-cell count, 16S ribosomal DNA load, regulatory positive...
Antisynthetase syndrome (aSS) corresponds to an overlapping inflammatory myopathy identified by various myositis-specific autoantibodies (directed against tRNA-synthetases). Myocardial involvement in this condition is poorly described. From a registry of 352 aSS patients, 12 cases myocarditis were retrospectively on the basis unexplained increase troponin T/I levels associated with either suggestive cardiac magnetic resonance imaging (MRI) findings, nonsignificant coronary artery...
Abstract Objective HCQ is an essential medication in SLE, proven to lengthen survival and reduce flares. Its use, however, limited by its rare but severe ophthalmological complications. Here, we aimed analyse factors associated with retinopathy including blood levels. Methods This case–control study compared SLE patients without retinopathy, defined abnormal results for at least two of the following tests: automated visual fields, spectral-domain optical coherence tomography (SD-OCT),...
Systemic lupus erythematosus (SLE) is a systemic autoimmune disease characterized by loss of tolerance toward self-nucleic acids, autoantibody production, interferon expression and signaling, defect in the regulatory T (T reg ) cell compartment. In this work, we identified that platelets from patients with active SLE preferentially interacted cells via P-selectin/P-selectin glycoprotein ligand-1 (PSGL-1) axis. Selectin interaction PSGL-1 blocked suppressive properties particularly follicular...
To assess the impact of HIV-1 protease mutations and intracellular plasma lopinavir minimum concentrations (Cmin) on virological success or failure lopinavir/ritonavir-containing highly active antiretroviral therapy (HAART).HIV-1-infected HAART-experienced patients included in an observational study, received lopinavir/ritonavir (400/100 mg twice a day) plus two to three nucleoside reverse transcriptase inhibitors (NRTI) one NRTI non-NRTI. A viral load less than 50 copies/ml at month 6...