A5037664471- Genetic factors in colorectal cancer
- Renal cell carcinoma treatment
- Gastric Cancer Management and Outcomes
- Cancer, Hypoxia, and Metabolism
- Esophageal Cancer Research and Treatment
- Renal and related cancers
- Colorectal Cancer Treatments and Studies
- Gastrointestinal Tumor Research and Treatment
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Cancer Genomics and Diagnostics
- Colorectal Cancer Screening and Detection
- Cardiac tumors and thrombi
- Medical Imaging and Pathology Studies
- Gastrointestinal disorders and treatments
- Tuberous Sclerosis Complex Research
- Metastasis and carcinoma case studies
- Liver Disease Diagnosis and Treatment
- Pancreatic and Hepatic Oncology Research
- Biliary and Gastrointestinal Fistulas
- Cancer-related Molecular Pathways
- Neuroendocrine Tumor Research Advances
- Cancer Diagnosis and Treatment
- Multiple and Secondary Primary Cancers
- Forensic Toxicology and Drug Analysis
- Poisoning and overdose treatments
Centre Hospitalier Universitaire de Limoges
2009-2025
Hôpital Dupuytren
2009-2022
Université de Limoges
2002-2022
Hôpital Universitaire Dupuytren
2004-2020
Université Lille Nord de France
2012
Hôpital Necker-Enfants Malades
1990-2010
Assistance Publique – Hôpitaux de Paris
1996-2010
Hôpital Femme Mère Enfant
2010
Université Paris Cité
2010
Centre Hospitalier Universitaire de Rouen
2010
A distinctive tumor described under the terms Bellini duct carcinoma and low-grade collecting has been referred to by us others as tubulocystic carcinoma. This renal cell subtype is not recognized in World Health Organization 2004 classification. Herein, we present a detailed study of 31 cases further characterize this rare The occurred adults (mean age, 54 years) with strong male predominance (7:1). Grossly, tumors ranged from 0.7 17 cm, exhibited spongy or "bubble wrap" appearance...
Numerous reviews of adenocarcinoma arising in Barrett's esophagus have been reported, but detailed pathologic findings or survival analysis rarely provided. This retrospective study analyzed 67 patients (mean age, 64 years; male-to-female ratio, 10:1) with an treated by surgical resection. Prevalence smokers was 63%, alcohol users, 45%, and hiatal hernia, 73%. Five had another synchronous cancer, seven patients, previous esophageal surgery. Forty percent the tumors were well differentiated,...
Unusual fat-containing renal tumors in a series of 27 cases comprised five categories: atypical and complicated angiomyolipomas (AMLs) (n = 15), including AMLs with extrarenal growth 5), undetectable fat 4), hemorrhagic 6); cell carcinomas (RCCs) 9); lipoma 1); liposarcoma oncocytoma 1). Fat was present within RCCs by the following mechanisms; lipid-producing necrosis large RCC 2), intratumoral bone metaplasia fatty marrow elements calcification small entrapment perirenal 4) or sinus 1)...
KRAS mutations are the most common oncogenic event in colorectal cancer (CRC) progression and their occurrence is associated with lack of response to anti epidermal growth factor receptor (EGFR) targeted therapies. Using preclinical models patients' samples we recently reported that emergence but also amplification acquired resistance EGFR inhibitors cetuximab or panitumumab. We reasoned may be responsible for primary these agents. Furthermore, while prevalence has been well established CRC,...
Phenotypic identification of focal nodular hyperplasia (FNH) and hepatocellular adenoma (HCA) subtypes using immunohistochemical markers has been developed from their molecular characteristics. Our objective was to evaluate the sensitivity these in definitive diagnosis lesions by core needle biopsies. A total 239 biopsies paired with surgical resection specimen (group A) or without an associated B) were reviewed. Using a step-by-step algorithm after standard staining, appropriate...
It is widely believed that demonstration of fat within a well-marginated renal tumor at computed tomography (CT) highly suggestive angiomyolipoma and can rule out cell carcinoma. The authors describe patient in whom CT demonstrated solid mass containing calcifications small amounts fat. Renal carcinoma was diagnosed pathologic examination. had tubular papillary architectural configurations associated with areas osseous metaplasia located the fibrous stroma tumor. should be considered...
Background Renal angiomyolipoma is a benign tumor histologically characterized by proliferation of spindle cells, epithelioid and adipocytic cells in concert with many thick-walled blood vessels. To add further diagnostic confusion, an cell-predominant variant renal has recently been described. HMB-45 immunoreactivity correlates ultrastructural striated organelles that closely resemble premelanosomes, although no evidence melanogenesis documented this tumor. Objective characterize the...
Abstract Background.—Renal angiomyolipoma is a benign tumor histologically characterized by proliferation of spindle cells, epithelioid and adipocytic cells in concert with many thick-walled blood vessels. To add further diagnostic confusion, an cell–predominant variant renal has recently been described. HMB-45 immunoreactivity correlates ultrastructural striated organelles that closely resemble premelanosomes, although no evidence melanogenesis documented this tumor. Objective.—To...
AIMS--To establish the prevalence of c-erbB-2 protein expression in a surgical series Barrett9s adenocarcinomas; and to correlate this with clinicopathological data prognosis. METHODS--Sixty six specimens adenocarcinomas were included retrospective study. Blocks tumour non-dysplastic mucosa stained polyclonal antibody specific for intracytoplasmic domain protein. RESULTS--Seven 66 tumours showed membrane staining The was negative all cases. There no difference between positive regard mean...
Non-infectious aortitis encompasses various histological patterns, but their specific cardiovascular outcomes remain unclear. To evaluate the mortality associated with non-infectious surgical thoracic aortitis. This retrospective multicenter study included patients who underwent aortic surgery and had evidence of The analyzed characteristics presenting either a granulomatous/giant cell pattern or lymphoplasmacytic pattern. Factors were identified using multivariate analysis. Among 5666...
The purpose of this study was to determine the angiogenic profile human oesophageal adenocarcinoma. This carried out on a large series surgically resected Barrett's adenocarcinomas and associated preneoplastic lesions. Vascularization quantified by microvessel counting measurement percentage surface area after immunohistochemistry using CD34 antibody. expression vascular endothelial cell growth factor (VEGF) also examined immunohistochemistry. Results were correlated with...
Context Microsatellite instability (MSI) due to defective mismatch repair (MMR) genes has been reported in the majority of colorectal tumors from patients with hereditary nonpolyposis cancer syndrome and 10% 15% sporadic cancers. The identification cancers associated MSI requires classical molecular testing as gold standard. Objective aim this study was evaluate role immunohistochemistry antibodies directed against 4 MMR proteins a screening tool for carcinomas MSI. Methods In study, 204...
Abstract Context.—Microsatellite instability (MSI) due to defective mismatch repair (MMR) genes has been reported in the majority of colorectal tumors from patients with hereditary nonpolyposis cancer syndrome and 10% 15% sporadic cancers. The identification cancers associated MSI requires classical molecular testing as gold standard. Objective.—The aim this study was evaluate role immunohistochemistry antibodies directed against 4 MMR proteins a screening tool for carcinomas MSI....
Aims: To establish the prevalence of cyclooxygenase‐2 (COX‐2) expression in a large series resected Barrett's adenocarcinoma and associated preneoplastic lesions to correlate this with clinicopathological data prognosis. Methods: COX‐2 was assessed by immunohistochemistry surgical specimens 66 adenocarcinomas 32 cases mucosa (with dysplasia 17 cases). Results: Epithelial protein increased compared normal oesophagus. found 91% specialized negative for dysplasia, 94% 97% adenocarcinoma....
It remains presently unclear whether disease progression in colorectal carcinoma (CRC), from early, to invasive and metastatic forms, is associated a gradual increase genetic instability scheme of sequentially occurring Copy Number Alterations (CNAs). In this work we set determine the existence such links between CRC searched for associations with patient outcome. To aim analyzed 162 Chromosomal Instable (CIN) CRCs comprising 131 primary carcinomas evenly distributed through stage 1 4, 31...
To identify juvenile idiopathic arthritis (JIA) patients who developed IBD during treatment with anti-TNF-alpha agents and better characterize the clinical pathological presentation.A retrospective French multicentre study included a diagnosis of JIA according to ILAR criteria while under therapy before 18 years age. Intestinal biopsies were collected reviewed by same pathologist.Eight included. They had been treated etanercept from 11 78 months onset. Gastro-intestinal symptoms abdominal...
Objective To evaluate the accuracy of endorectal magnetic resonance imaging (MRI) with fast spin‐echo sequences in local staging clinically localized prostate cancer. Patients and methods Seventy‐one patients a clinical T1 (18 patients) or T2 tumour (53 underwent MRI 2–12 weeks before radical prostatectomy. Extraprostatic was diagnosed if showed signs capsular penetration and/or invasion seminal vesicle distal urethra bladder neck. If pathological examination single positive margin no...