A5036173072- Vasculitis and related conditions
- Lipoproteins and Cardiovascular Health
- Otitis Media and Relapsing Polychondritis
- Systemic Lupus Erythematosus Research
- Systemic Sclerosis and Related Diseases
- Peripheral Artery Disease Management
- Venous Thromboembolism Diagnosis and Management
- Vascular Anomalies and Treatments
- Renal Diseases and Glomerulopathies
- Cerebrovascular and Carotid Artery Diseases
- Cardiomyopathy and Myosin Studies
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Antiplatelet Therapy and Cardiovascular Diseases
- Aortic aneurysm repair treatments
- Atherosclerosis and Cardiovascular Diseases
- Sarcoidosis and Beryllium Toxicity Research
- Intracranial Aneurysms: Treatment and Complications
- Diagnosis and Treatment of Venous Diseases
- Coronary Interventions and Diagnostics
- Sports injuries and prevention
- IgG4-Related and Inflammatory Diseases
- Nutrition and Health in Aging
- Long-Term Effects of COVID-19
- Acute Ischemic Stroke Management
- Vascular Procedures and Complications
Hôpital Saint-Antoine
2018-2025
Institut Pierre Louis d‘Épidémiologie et de Santé Publique
2018-2025
Nantes Université
2022-2025
Institut du Thorax
2023-2025
Inserm
2018-2025
Centre National de la Recherche Scientifique
2023-2025
Sorbonne Université
2018-2025
Assistance Publique – Hôpitaux de Paris
2018-2024
Hôpital Européen Georges-Pompidou
2021-2024
Hôpital Européen
2021-2024
A new autoinflammatory syndrome related to somatic mutations of UBA1 was recently described and called VEXAS ('Vacuoles, E1 Enzyme, X-linked, Autoinflammatory, Somatic syndrome').To describe clinical characteristics, laboratory findings outcomes syndrome.One hundred sixteen patients with were referred a French multicentre registry between November 2020 May 2021. The frequency median parameters vital status, from diagnosis the end follow-up, recorded.The main features found be skin lesions...
Objective A new adult-onset autoinflammatory syndrome has been described, named VEXAS (Vacuoles, E1 Enzyme, X-linked, Autoinflammatory, Somatic). We aimed to compare the clinical characteristics, laboratory features and outcomes between idiopathic-relapsing polychondritis (I-RP) VEXAS-relapsing (VEXAS-RP). Methods Patients from French retrospective multicentre cohort of RP were separated into two groups: a VEXAS-RP an I-RP. Results Compared with patients I-RP (n=40), (n=55) men (96% vs 30%,...
Non-infectious aortitis encompasses various histological patterns, but their specific cardiovascular outcomes remain unclear. To evaluate the mortality associated with non-infectious surgical thoracic aortitis. This retrospective multicenter study included patients who underwent aortic surgery and had evidence of The analyzed characteristics presenting either a granulomatous/giant cell pattern or lymphoplasmacytic pattern. Factors were identified using multivariate analysis. Among 5666...
Introduction Idiopathic inflammatory myositis (IIM) are systemic diseases, including dermatomyositis (DM), inclusion body (IBM), immune-mediated necrotising myopathy (IMNM), antisynthetase syndrome (ASSD) and overlap (OM). Patients with IIM have an increased risk of premature death, largely due to cardiovascular events (CVE). The aim this study was describe specific non-specific cardiac involvement in patients IIM, assess the occurrence CVE. Methods We conducted a retrospective observational...
Peripheral arterial dissections are uncommon, with cervical artery being the most prevalent type. Comparative data on evolution of renal, splanchnic, and coronary scarce. This study aimed to characterise assess prognosis non-aortic based their anatomical territories. Patients dissection cervical, coronary, or splanchnic arteries from 2017 - 2022 for which episode was documented at Nantes University Hospital were retrospectively included. A total 185 patients Compared other territories,...
We report the 11 cases of +8-MDS/MPN associated with Behcet's-like syndrome and compare them Behcet's disease Crohn's disease, pool literature for analysis. Data patients Behçet's-like were collected from MINHEMON. Eleven had (median age 75 years [IQR 65–87]; M/F ratio 0.8). MDS diagnosed at same time (7/11, 64%). By comparison 63 idiopathic without MDS, those older vs 48 years; p = .0003) less pseudofolliculitis (11% 62%; .0045) ocular impairment (0% 52%; .0008), but more frequent...
High lipoprotein(a) (Lp[a]) levels are involved in the development of cardiovascular events, particularly myocardial infarction, stroke, and peripheral artery disease. Studies assessing Lp(a) associated with adverse lower-limb events lacking.To assess association between incidence major limb unselected hospitalized patients.This large retrospective monocentric cohort study was conducted from January 1, 2000, to December 31, 2020. Data were derived clinical information system Hôpital Européen...
Introduction Antiphospholipid syndrome (APS) is an autoimmune disease characterised by thrombosis (arterial, venous or small vessel) obstetrical events and persistent antiphospholipid antibodies (aPL), according to the Sydney classification criteria. Many studies have performed cluster analyses among patients with primary APS associated disease, but none has focused solely on APS. We aimed perform a analysis asymptomatic aPL carriers without any assess prognostic value. Methods In this...
Abstract Background From this retrospective study, we aimed to (1) describe the prevalence and characteristics of non-criteria features in primary antiphospholipid syndrome (p-APS) (2) determine their prognostic value. Methods This French multicenter cohort study included all patients diagnosed with p-APS (Sydney criteria) between January 2012 2019. We used Kaplan-Meier adjusted Cox proportional hazards models compare incidence relapse without manifestations. Results One hundred seventy-nine...
We report cases of myelodysplastic syndrome/myeloproliferative neoplasms (MDS/MPN) with trisomy 8 associated inflammatory and autoimmune diseases (IADs).Data for 21 patients 8-MDS/MPN IADs were analyzed compared to 103 without IADs.The median age MDS/MPN was 67 [59-80]. The Behçet's-like disease in 11 (52%) patients, arthritis 4 (19%) Sjögren's syndrome, hemolytic anemia, aseptic abscess, periarteritis nodosa, Sweet's syndrome unclassified vasculitis one patient each. Overall, 17/21 (81%)...
Immune checkpoint inhibitors (ICIs) have revolutionized the management of cancers. The risk factors and pathophysiological mechanisms venous thromboembolic events (VTEs) this new therapeutic class are still to be specified. included patients had cancer should treated with ICI. Data analyzed demographic data, biological immune-related adverse (IRAEs). We studied prevalence VTEs associated VTEs. Of 374 on ICI, over a median follow-up period 15.2 months, number VTE was 50 (13.4%). majority were...
Giant cell arteritis (GCA) is one of the most common large vessel (LVV) vasculitis and associated with a high risk relapse cardiovascular complications. Improving stratification remains significant issue in this patient population. We aimed to perform cluster analysis among GCA identify clusters evaluate their prognostic value.
Proprotein convertase subtilisin kexin type 9 (PCSK9) inhibitors lower low-density lipoprotein (LDL) cholesterol in the vast majority of patients with autosomal dominant familial hypercholesterolemia. Will PCSK9 inhibition monoclonal antibodies, particular alirocumab, be therapeutic value for recessive hypercholesterolemia (ARH)?Primary lymphocytes were obtained from 28 genetically characterized ARH and 11 controls. treated mevastatin incubated increasing doses recombinant or without...