Jean‐David Bouaziz
A5081595212- Autoimmune Bullous Skin Diseases
- Cutaneous lymphoproliferative disorders research
- Eosinophilic Disorders and Syndromes
- Dermatology and Skin Diseases
- Inflammatory Myopathies and Dermatomyositis
- Autoimmune and Inflammatory Disorders
- Skin Diseases and Diabetes
- Urticaria and Related Conditions
- T-cell and B-cell Immunology
- Immune Cell Function and Interaction
- Systemic Lupus Erythematosus Research
- Lymphoma Diagnosis and Treatment
- Histiocytic Disorders and Treatments
- Dermatological and COVID-19 studies
- Fungal Infections and Studies
- Chronic Lymphocytic Leukemia Research
- Oral Health Pathology and Treatment
- Dermatological and Skeletal Disorders
- Nail Diseases and Treatments
- Allergic Rhinitis and Sensitization
- Hematopoietic Stem Cell Transplantation
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Systemic Sclerosis and Related Diseases
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Psoriasis: Treatment and Pathogenesis
Hôpital Saint-Louis
2016-2025
Assistance Publique – Hôpitaux de Paris
2016-2025
Université Paris Cité
2016-2025
Inserm
2016-2025
Sorbonne Paris Cité
2014-2025
HIPI - Immunologie humaine, physiopathologie et immunithérapie
2014-2024
Institut de recherche Saint-Louis
2019-2024
Délégation Paris 7
2014-2023
Skin Research Center
2010-2023
RELX Group (United States)
2023
EAE is a mouse T cell–mediated autoimmune disease of the CNS used to model human condition MS. The contributions B cells initiation and progression are unclear. In this study, we have shown that differentially influenced by depletion from mice with otherwise intact immune systems. CD20 antibody–mediated cell before induction substantially exacerbated symptoms increased encephalitogenic influx into CNS. Increased symptom severity resulted rare IL-10–producing CD1dhiCD5+ regulatory subset (B10...
Autoimmunity and inflammation are controlled in part by regulatory B cells, including a recently identified IL-10-competent CD1d(high)CD5(+) cell subset termed B10 cells that represents 1-3% of adult mouse spleen cells. In this study, pathways influence generation IL-10 production were compared with previously described predominantly the prevalent source IL-10, but not other cytokines. development and/or maturation vivo required Ag receptor diversity intact signaling pathways, T...
B cell depletion significantly reduces the burden of several immune-mediated diseases. However, activation has been until now associated with a protection against atherosclerosis, suggesting that cell–depleting therapies would enhance cardiovascular risk. We unexpectedly show mature using CD20-specific monoclonal antibody induces significant reduction atherosclerosis in various mouse models disease. This treatment preserves production natural and potentially protective anti–oxidized...
CD20 antibody depletion of B lymphocytes effectively ameliorates multiple T cell-mediated autoimmune diseases through mechanisms that remain unclear. To address this, a mouse depletes >95% mature cells in mice with otherwise intact immune systems was used to assess the role CD4 + and CD8 cell activation expansion vivo . had no direct effect on subsets or status naive mice. However, impaired clonal response protein antigens pathogen challenge, whereas not affected. In dendritic ablation,...
A new autoinflammatory syndrome related to somatic mutations of UBA1 was recently described and called VEXAS ('Vacuoles, E1 Enzyme, X-linked, Autoinflammatory, Somatic syndrome').To describe clinical characteristics, laboratory findings outcomes syndrome.One hundred sixteen patients with were referred a French multicentre registry between November 2020 May 2021. The frequency median parameters vital status, from diagnosis the end follow-up, recorded.The main features found be skin lesions...
Abstract The term ‘sclerosing diseases of the skin' comprises specific dermatological entities, which have fibrotic changes skin in common. These mostly manifest different clinical subtypes according to cutaneous and extracutaneous involvement can sometimes be difficult distinguish from each other. present guideline focuses on characteristic histopathological features, diagnostic scores serum autoantibodies most useful for differential diagnosis. In addition, current strategies first‐...
Significant unmet need exists for long-term treatment of moderate to severe atopic dermatitis (AD).To assess the safety and efficacy dupilumab in patients with AD.This ongoing, multicenter, open-label extension study (NCT01949311) evaluated adults who had previously participated phase 1 through 3 clinical trials AD. This analysis examined given 300 mg weekly up 76 weeks at data cutoff (April 2016). Safety was primary outcome; also evaluated.Of 1491 enrolled (1042.9 patient-years), 92.9% were...
Nemolizumab targets the IL-31 receptor α subunit involved in atopic dermatitis (AD) pathogenesis.We sought to evaluate a new dosing strategy of nemolizumab patients with AD.We performed 24-week, randomized, double-blind, multicenter study (10, 30, and 90 mg) subcutaneous injections every 4 weeks versus placebo, topical corticosteroids adults moderate-to-severe AD, severe pruritus, inadequate control treatment (n = 226). The Eczema Area Severity Index (EASI), peak pruritus (PP) numeric rating...
To the Editor: Coronavirus disease 19 (COVID-19), a pneumonia associated with severe acute respiratory syndrome coronavirus 2 (SARS-Cov2), was first identified in Wuhan, China, December 2019, and characterized as pandemic by World Health Organization on March 11, 2020. Fever, dry cough, dyspnea, fatigue, anorexia, ageusia, anosmia are common symptoms of COVID-19. Reported skin manifestations COVID-19 include erythematous lesions, sometimes dengue-like petechiae,1Joob B. Wiwanitkit V. can...
Vacuoles, E1 enzyme, X-linked, autoinflammatory and somatic (VEXAS) syndrome is an adult-onset disease associated with ubiquitin-like modifier-activating enzyme 1 (UBA1) mutations. We aimed to evaluate the efficacy safety of targeted therapies.
Abstract IL‐10‐producing regulatory B cells have been identified in mice and shown to downregulate inflammation, making them potentially important for maintenance of tolerance. In this study, we isolated from human blood spleen, showed that after a short period ex vivo stimulation number these produced IL‐10. The did not fall within single clearly defined subpopulation, but were enriched both the memory (CD27 + ) transitional (CD38 high B‐cell compartments. Combined CpG‐B+anti‐Ig was most...
Abstract NOD mice deficient for B lymphocytes from birth fail to develop autoimmune or type 1 diabetes. To assess whether cell depletion influences diabetes in with an intact immune system, female representing early and late preclinical stages of disease were treated mouse anti-mouse CD20 mAbs. Short-term mAb treatment 5-wk-old reduced numbers by ∼95%, decreased subsequent insulitis, prevented >60% littermates. In addition, 15-wk-old significantly delayed, but did not prevent, onset....
Background Alemtuzumab has been proposed as salvage therapy for refractory cutaneous T-cell lymphomas (CTCLs). Long-term follow-up data are scarce. Objectives To assess the efficacy and safety of alemtuzumab in treatment advanced CTCL. Methods A multicentre retrospective analysis was carried out 39 patients with CTCL treated between 2003 2013. Results Thirty-nine (median age 62 years, range 20–83) Sézary syndrome (SS, n = 23) or mycosis fungoides (MF, 16) received 30 mg two to three times...
The term 'sclerosing diseases of the skin' comprises specific dermatological entities which have fibrotic changes skin in common. These mostly manifest different clinical subtypes according to cutaneous and extracutaneous involvement can sometimes be difficult distinguish from each other. present guideline focuses on characteristic histopathological features, diagnostic scores serum autoantibodies most useful for differential diagnosis. In addition, current strategies first- advanced-line...
<h3>Importance</h3> VEXAS (vacuoles, E1 enzyme, X-linked, autoinflammatory, somatic) is a recently described severe adult-onset autoinflammatory disease that associated with myeloid lineage-restricted ubiquitin-activating enzyme 1 (<i>UBA1</i>) somatic variations primarily affect the skin (Sweet syndrome), cartilage, and bone marrow. Skin symptoms have been poorly described. <h3>Objective</h3> To better describe clinical pathological manifestations their pathophysiology in syndrome....