Boris Bienvenu
A5063812606- Vasculitis and related conditions
- Systemic Lupus Erythematosus Research
- Sarcoidosis and Beryllium Toxicity Research
- Otitis Media and Relapsing Polychondritis
- Renal Diseases and Glomerulopathies
- Atherosclerosis and Cardiovascular Diseases
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Systemic Sclerosis and Related Diseases
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Immunodeficiency and Autoimmune Disorders
- Eosinophilic Disorders and Syndromes
- Inflammatory Myopathies and Dermatomyositis
- Ocular Diseases and Behçet’s Syndrome
- Dermatological and Skeletal Disorders
- Connective tissue disorders research
- T-cell and B-cell Immunology
- Peripheral Neuropathies and Disorders
- Immune Cell Function and Interaction
- SARS-CoV-2 and COVID-19 Research
- Autoimmune Bullous Skin Diseases
- Chronic Lymphocytic Leukemia Research
- Urticaria and Related Conditions
- COVID-19 Clinical Research Studies
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Vascular Anomalies and Treatments
Hôpital Pellegrin
2025
Médecins du Monde
2023-2025
Hôpital Paul-Brousse
2025
Hôpital Saint Joseph
2017-2024
Centre hospitalier national d'ophtalmologie des Quinze-Vingts
2024
Centre Hospitalier Universitaire de Caen
2014-2023
Université de Caen Normandie
2012-2023
Université Paris Cité
2006-2022
Inserm
2004-2022
Assistance Publique – Hôpitaux de Paris
2006-2022
Abstract Objective Earlier studies of eosinophilic granulomatosis with polyangiitis (Churg‐Strauss) (EGPA), limited patient numbers and followup durations, demonstrated that clinical presentation at diagnosis, but not outcome, differed according to antineutrophil cytoplasmic antibody (ANCA) status. This study was undertaken describe the main characteristics a larger cohort their long‐term outcomes. Methods A retrospective EGPA patients in French Vasculitis Study Group who satisfied American...
Previous studies of polyarteritis nodosa (PAN) included patients with microscopic polyangiitis, because these entities were not distinguished prior to the Chapel Hill Consensus Conference (CHCC). This study was undertaken describe main characteristics and long-term outcomes in well-characterized PAN diagnoses.We conducted a systematic retrospective 348 who diagnosed as having between March 1963 October 2005, registered French Vasculitis Study Group database, satisfied American College...
A new autoinflammatory syndrome related to somatic mutations of UBA1 was recently described and called VEXAS ('Vacuoles, E1 Enzyme, X-linked, Autoinflammatory, Somatic syndrome').To describe clinical characteristics, laboratory findings outcomes syndrome.One hundred sixteen patients with were referred a French multicentre registry between November 2020 May 2021. The frequency median parameters vital status, from diagnosis the end follow-up, recorded.The main features found be skin lesions...
Dermatomyositis is an acquired auto-immune disease characterized by skin lesions and muscle-specific pathological features such as perifascicular muscle fibre atrophy vasculopathy. patients display upregulation of type I interferon-inducible genes in fibres, endothelial cells, peripheral blood. However, the effect interferon on tissue has not yet been determined. Our aim was to study pathogenicity vitro evaluate efficacy pathway blockade for therapeutic purposes. The activation...
To investigate a new therapeutic strategy, with rapid corticosteroid dose tapering and limited cyclophosphamide (CYC) exposure, for older patients systemic necrotizing vasculitides (SNVs; polyarteritis nodosa [PAN], granulomatosis polyangiitis [Wegnener's] [GPA], microscopic [MPA], or eosinophilic GPA [Churg-Strauss] [EGPA]).A multicenter, open-label, randomized controlled trial comprising ≥65 years old newly diagnosed as having SNV was conducted. The experimental treatment consisted of...
To define parameters predictive of lymphoma development in patients with primary Sjögren's syndrome (SS).A multicenter case-control survey was performed to identify predictors lymphoma. Cases were who developed after diagnosis SS and mainly recruited through the Club Rhumatismes et Inflammation network. For each case, 2 controls (matched for disease duration age) randomly selected among without compared using univariate analysis then multivariate independent lymphoma.One hundred one...
Objective To analyze the factors associated with response to anti–tumor necrosis factor (anti‐TNF) treatment and compare efficacy safety of infliximab (IFX) adalimumab (ADA) in patients refractory noninfectious uveitis. Methods This was a multicenter observational study 160 (39% men 61% women; median age 31 years [interquartile range 21–42]) uveitis that had been other therapies, who were treated anti‐TNF (IFX 5 mg/kg at weeks 0, 2, 6, then every 5–6 [n = 98] or ADA 40 mg 2 62]). Factors...
Objective: To characterise major infectious complications and analyse potential risk factors in patients with Wegener granulomatosis (WG). Methods: Data from 113 WG (69 male) followed at least once between January 1984 March 2006 our internal medicine department, were analysed retrospectively. Results: A total of 35 (mean (SD) age diagnosis: 50.2 (13.05) years) developed 53 infections. Infections were: bronchopneumonias (n = 19), herpes zoster recurrences 9), cellulitis 4), prostatitis...
In most patients with nonsevere systemic necrotizing vasculitides (SNVs), remission is achieved glucocorticoids alone, but one-third experience a relapse within 2 years. This study was undertaken to determine whether the addition of azathioprine (AZA) could achieve higher sustained rate newly diagnosed eosinophilic granulomatosis polyangiitis (Churg-Strauss) (EGPA), microscopic (MPA), or polyarteritis nodosa (PAN).All included in this double-blind trial received glucocorticoids, gradually...
Objective To describe characteristics and outcomes of a multicenter cohort patients diagnosed as having primary angiitis the central nervous system (PACNS). Methods In 2010, we initiated study adults PACNS ≤15 years ago with followup >6 months (unless they died earlier biopsy‐proven PACNS). Its first analysis was planned at 2 years. Multidisciplinary investigators verified that appropriate investigations were done excluded possible alternative diagnoses. We analyzed patient demographics...
Objective Data on adult IgA vasculitis (Henoch‐Schönlein) (IgAV) are scarce. This survey was designed to better define the clinical spectrum of IgAV and efficacy treatments in a French patient population. Methods characteristics, histologic features, treatment response from 260 patients with included multicenter retrospective were analyzed. Efficacy data compared using different statistical models. Results The mean ± SD age at diagnosis 50.1 18 years, 63% male. Baseline manifestations...
To describe the efficacy and safety of omalizumab, an anti-IgE monoclonal antibody, in patients with refractory and/or relapsing eosinophilic granulomatosis polyangiitis (Churg-Strauss) (EGPA).We conducted a nationwide retrospective study including EGPA who received omalizumab. Response was defined as absence asthma sinonasal exacerbations prednisone dosage ≤7.5 mg/day (complete response) or >7.5 (partial response).Seventeen (median age 45 years) omalizumab for severe steroid-dependent (88%)...
Previous studies reported a 2- to 17-fold higher risk of aortic complications (dilation or dissection) in patients with giant-cell arteritis (GCA). We aimed determine whether not GCA large-vessel involvement demonstrated by positron emission tomography 18F-fluorodeoxyglucose combined computed (FDG-PET/CT) have complications. conducted retrospective multicenter study between 1995 and 2014. Patients were included if they fulfilled at least 3 American College Rheumatology criteria for GCA, 2...
Objective. Our aim was to describe patients with giant cell arteritis (GCA)–related stroke and compare them a control group of GCA without stroke. Methods. We created retrospective multicenter cohort (1) diagnosed according the American College Rheumatology criteria between 1995 2015, (2) occurring at time diagnosis or within 4 weeks starting therapy. The consisted Results. Forty [21 women (53%), median age 78 (60–91) yrs] GCA-related were included compared 200 patients. Stroke occurred in...