A5001167149- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Sarcoidosis and Beryllium Toxicity Research
- Infectious Diseases and Tuberculosis
- Tuberculosis Research and Epidemiology
- Medical Imaging and Pathology Studies
- Occupational and environmental lung diseases
- Sinusitis and nasal conditions
- Neonatal Respiratory Health Research
- Mycobacterium research and diagnosis
- Autoimmune and Inflammatory Disorders
- Diagnosis and treatment of tuberculosis
- Drug-Induced Adverse Reactions
- Pulmonary Hypertension Research and Treatments
- Dermatological diseases and infestations
- Inhalation and Respiratory Drug Delivery
- Pneumocystis jirovecii pneumonia detection and treatment
- Immunodeficiency and Autoimmune Disorders
- Pleural and Pulmonary Diseases
- Bacillus and Francisella bacterial research
- Occupational exposure and asthma
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Antifungal resistance and susceptibility
- T-cell and B-cell Immunology
- Vasculitis and related conditions
- interferon and immune responses
Hôpital Avicenne
2016-2025
Inserm
2004-2025
Sorbonne Université
2007-2024
Assistance Publique – Hôpitaux de Paris
2015-2024
Université Sorbonne Paris Nord
2012-2024
Université Paris Cité
2006-2020
Sorbonne Paris Cité
2016-2020
Association pour la Recherche en Physiologie de l’Environnement
2019
Hypoxie et Poumon
2018
Université Sorbonne Nouvelle
2018
Rationale New approaches to define factors underlying the immunopathogenesis of pulmonary diseases including sarcoidosis and tuberculosis are needed develop new treatments biomarkers. Comparing blood transcriptional response other similar will advance knowledge disease pathways help distinguish with clinical presentations. Objectives To determine granulomatous diseases, tuberculosis, by comparing responses in these diseases. Methods We compared whole genome-wide profiles sarcoidosis,...
CD4(+) regulatory T (Treg) cells expressing CD25 and the transcription factor forkhead box P3 (FOXP3) are indispensable for immunological self-tolerance homeostasis. FOXP3(+)CD25(+)CD4(+) in humans, however, heterogeneous function differentiation status, including suppressive or nonsuppressive as well resting activated Treg cells. We have searched cell surface markers specific suppression-competent by using a panel of currently available monoclonal antibodies reactive with human found that...
<i>Background:</i> Acute exacerbation is a substantial cause of death in patients with idiopathic pulmonary fibrosis poorly described prognostic factors. <i>Objectives:</i> To review the features associated acute and assess its <i>Methods:</i> Thirty-seven occurrences were retrospectively reviewed medical records 27 patients. Clinical presentation, radiographic studies, function tests, laboratory data, treatment, outcome analyzed....
To compare the efficacy of methotrexate (MTX) and mycophenolate mofetil (MMF) in prevention relapses neurosarcoidosis.We conducted a retrospective multicenter study including patients who received MTX or MMF for treatment histologically proven neurosarcoidosis. The immunosuppressive drug was assessed by determining time to relapse.Forty with diagnosis neurosarcoidosis (24 men, 16 women, median age at 43.5 years) least 3 months (n = 32) 14) were included. always associated steroids. rate...
The aim of the present study was to investigate what extent interstitial lung disease (ILD) in common variable immunodeficiency disorder (CVID)-associated granulomatous (GD) is similar pulmonary sarcoidosis 20 patients with CVID/GD were included a retrospective conducted by Groupe Sarcoïdose Francophone. Medical records centralised. Patients compared 60 controls sarcoidosis. Clinical examination showed more frequent crackles than (45% versus 1.7%, respectively; p<0.001). On thoracic...
Chronic pulmonary aspergillosis (CPA) complicating sarcoidosis (SA) is associated with high mortality, and there a lack of clarity regarding the relative contributions SA or CPA.This was retrospective single-centre study on CPA-SA.In total, 65 patients (44 men), aged 41.4±13.5 48.3±11.9 years at time CPA diagnoses, respectively, were included between 1980 2015. Of these, 64 had fibrocystic SA, most often advanced, composite physiological index (CPI) >40 (65% patients) hypertension (PH)...
Regulator of telomere length 1 ( RTEL1 ) mutations have been evidenced in 5–9% familial pulmonary fibrosis; however, the phenotype patients with interstitial lung disease (ILD) and is poorly understood. Whole exome sequencing was performed 252 probands ILD we included all mutation. expression evaluated by immunochemistry lungs controls, as well telomerase reverse transcriptase TERT mutation carriers. We identified 35 subjects from 17 families. Median age at diagnosis 53.1 years (range...
Evidence for the long-term efficacy and safety of anti-tumor necrosis factor α agents (anti-TNF) in treating cutaneous sarcoidosis is lacking.To determine anti-TNF a large observational study.STAT (Sarcoidosis Treated with Anti-TNF) French retrospective prospective multicenter database that receives data from teaching hospitals referral centers, as well several pneumology, dermatology, internal medicine departments. Included patients had histologically proven received between January 2004...
Approximately 30% of individuals diagnosed with familial pulmonary fibrosis (FPF) exhibit a pathogenic variant upon genetic analysis. We established Multidisciplinary Discussion (geneMDD) aimed to enhance expertise in diagnosing and managing FPF. This study at prospectively evaluating the impact geneMDD on diagnosis treatment patients referred geneMDD. In this prospective study, we enrolled all consecutive At each meeting, meeting was questioned conclusion, diagnosis, treatment. A total 115...
Section:ChooseTop of pageAbstract <<MATERIALS AND METHODSRESULTSDISCUSSIONReferencesCITING ARTICLES
<h3>Objective:</h3> To describe characteristics, risk factors, and treatment outcome of progressive multifocal leukoencephalopathy (PML) complicating sarcoidosis. <h3>Methods:</h3> A retrospective chart literature review was performed. Patients were identified through records from physicians the Groupe Sarcoïdose Francophone. Each case compared with 3 controls. <h3>Results:</h3> Ten cases found (8 men). The median age at sarcoidosis diagnosis 34.9 (±6) years. PML diagnosed concomitantly in 2...
Scedosporiosis/lomentosporiosis is a devastating emerging fungal infection. Our objective was to describe the clinical pattern and analyze whether taxonomic grouping of species involved supported by differences in terms presentations or outcomes. We retrospectively studied cases invasive scedosporiosis France from 2005 through 2017 based on isolates characterized polyphasic approach. recorded 90 cases, mainly related Scedosporium apiospermum (n = 48), S. boydii/S. ellipsoideum 20),...
Introduction Interstitial lung diseases (ILDs) can be caused by mutations in the SFTPA1 and SFTPA2 genes, which encode surfactant protein (SP) complex SP-A. Only 11 or have so far been reported worldwide, of five functionally assessed. In framework ILD molecular diagnosis, we identified 14 independent patients with pathogenic mutations. The present study aimed to assess different accurately describe disease phenotype their affected relatives. Methods consequences were analysed both vitro ,...
Rationale: New approaches to define factors underlying the immunopathogenesis of pulmonary diseases including sarcoidosis and tuberculosis are needed develop new treatments biomarkers.Comparing blood transcriptional response other similar will advance knowledge disease pathways help distinguish with clinical presentations.Objectives: To determine granulomatous diseases, tuberculosis, by comparing responses in these diseases. Methods:We compared whole genome-wide profiles sarcoidosis,...
Abstract Background Genetic testing is proposed for suspected cases of monogenic pulmonary fibrosis, but clinicians and patients need specific information recommendation about the related diagnosis management issues. Because multidisciplinary discussion (MDD) has been shown to improve accuracy interstitial lung disease (ILD) diagnosis, we evaluated feasibility a genetic MDD (geneMDD) dedicated indication interpretation testing. The geneMDD group met monthly included pediatric adult...
Sarcoidosis is a systemic disease characterized by the formation of immune granulomas in various organs, mainly lungs and lymphatic system. Exaggerated granulomatous reaction might be triggered response to unidentified antigens individuals with genetic susceptibility. The present study aimed determine variants implicated familial case sarcoidosis. presentation history, NOD2 profile, NF-κB cytokine production blood monocytes/macrophages were evaluated from family late appearance In study, we...