A5100423137- Glaucoma and retinal disorders
- Assisted Reproductive Technology and Twin Pregnancy
- Long-Term Effects of COVID-19
- COVID-19 Clinical Research Studies
- SARS-CoV-2 and COVID-19 Research
- Viral gastroenteritis research and epidemiology
- Ophthalmology and Visual Impairment Studies
- Retinal Diseases and Treatments
- Ovarian function and disorders
- Inflammasome and immune disorders
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Dermatological diseases and infestations
- Infection Control and Ventilation
- Antifungal resistance and susceptibility
- Tuberculosis Research and Epidemiology
- Antimicrobial Resistance in Staphylococcus
- Animal Virus Infections Studies
- Wind and Air Flow Studies
- Reproductive Biology and Fertility
- Adolescent and Pediatric Healthcare
- Autoimmune Bullous Skin Diseases
- Mycobacterium research and diagnosis
- Respiratory Support and Mechanisms
- Cancer Genomics and Diagnostics
- Infectious Diseases and Tuberculosis
Sun Yat-sen University
2024
Huazhong Agricultural University
2024
China Animal Health and Epidemiology Center
2020-2024
Zunyi Medical University
2024
University of Science and Technology of China
2024
Affiliated Eye Hospital of Wenzhou Medical College
2021-2024
Wenzhou Medical University
2021-2024
Xi’an Jiaotong-Liverpool University
2024
Qiqihar Medical University
2024
Institut Pasteur of Shanghai
2023
Rationale New approaches to define factors underlying the immunopathogenesis of pulmonary diseases including sarcoidosis and tuberculosis are needed develop new treatments biomarkers. Comparing blood transcriptional response other similar will advance knowledge disease pathways help distinguish with clinical presentations. Objectives To determine granulomatous diseases, tuberculosis, by comparing responses in these diseases. Methods We compared whole genome-wide profiles sarcoidosis,...
Purpose: The purpose of this study was to evaluate the interocular differences in choroidal vasculature, choriocapillaris perfusion, and retinal microvascular network, explore their associations with asymmetry axial lengths (ALs) children anisomyopia. Methods: Refractive error, AL, other biometric parameters were measured 70 Using optical coherence tomography (OCT) OCT-angiography, we submacular thickness (ChT), total area (TCA), luminal (LA), stromal (SA), vascularity index (CVI), flow...
Although age and parity are recognized as associated factors for adverse pregnancy outcomes, there no studies exploring the interaction between two during pregnancy. This study aimed to investigate impact of on outcomes.This was a retrospective cohort with 15,861 women aged ≥20 years. All were grouped according age, parity, mix two. The data analyzed using multivariate logistic regression analysis.Age, related risk gestational hypertension, eclampsia/pre-eclampsia, placenta previa, placental...
Abstract The multibasic furin cleavage site at the S1/S2 boundary of spike protein is a hallmark SARS-CoV-2 and plays crucial role in viral infection. However, mechanism underlying activation its regulation remain poorly understood. Here, we show that GalNAc-T3 T7 jointly initiate clustered O -glycosylations protein, which inhibit processing, suppress incorporation into virus-like-particles affect Mechanistic analysis reveals assembly virus-like particles relies on interactions between...
Objectives: This study aimed to explore potential differences in efficacy between vaginal progesterone (VPG) and VPG+oral (OPG) for luteal-phase support hormone replacement therapy-frozen embryo transfer (HRT-FET) cycles. Design: A single-centre, open-label, randomized controlled, phase IV pilot study. Participants/Materials, Setting, Methods: Infertile women aged 20–38 years undergoing HRT-FET cycles were included. Participants VPG (n=86) or VPG+OPG (n=86). The primary endpoint was ongoing...
Acute lymphoblastic leukaemia (ALL) is the most common childhood malignancy. Caring for children with ALL an uncommon experience parents without medical training. They urgently need professional assistance when their are recovering at home. This paper documents process of developing Android application (app) “Care Assistant” family caregivers ALL. Key informant interviews and focus group studies were used before programming app. The key informants members included: ALL, cancer care...
Introduction Emerging evidence has shown that in-vitro fertilization (IVF) is associated with higher risks of certain placental abnormalities or complications, such as abruption, preeclampsia, and preterm birth. However, there a lack large population-based analysis focusing on complications following IVF treatment. This study aimed to estimate the absolute risk during IVF-conceived pregnancy. Methods We conducted retrospective cohort 16 535 852 singleton pregnancies delivery outcomes in...
Background To assess predictive value of short-term choroidal changes for future myopic shift in children. Methods 577 eyes 289 primary school children were prospectively followed 2 years. Cycloplegic refractions at baseline, 1 year and years, measurements by optical coherence tomography baseline 3 months, used analyses. Myopic was defined as refraction change least −0.50 dioptre/year, years compared with baseline. Results 228 participants (455 eyes) completed 2-year follow-up. Approximately...
The SARS-CoV-2 main protease (Mpro, also known as 3CLpro) is a key target for antiviral therapy due to its critical role in viral replication and maturation. This study investigated the inhibitory effects of Bofutrelvir, Nirmatrelvir, Selinexor on 3CLpro through molecular docking, dynamics (MD) simulations, free energy calculations. Nirmatrelvir exhibited strongest binding affinity across docking tools (AutoDock Vina: -8.3 kcal/mol; DiffDock: -7.75 DynamicBound: 7.59 7.89 kcal/mol),...
The present study analyzed the correlation of DNA polymerase β (DNA polβ) promoter mutations and activity in esophageal squamous cell carcinoma (ESCC). polβ was amplified from 108 ESCC samples adjacent paracancerous by PCR cloned into pGL3-enhancer luciferase vector. recombined vectors were transfected cells (EC9706, Eca109, KYSE30), detected using dual reporter gene technology. Eleven identified submitted to GenBank. mutation rate higher tissues (36/108, 33.3 %) than paired (21/108, 19.4 (P...
Glaucoma is one of the leading irreversible causes blindness worldwide, and previous studies have shown that there abnormal functional connectivity (FC) in visual cortex glaucoma patients. The thalamus a relay nucleus for signals; however, it not yet clear how FC altered glaucoma. This study investigated alterations thalamic patients with primary angle-closure (PACG) by using resting-state MRI (rs-fMRI). We hypothesized PACG between as well extravisual brain regions.Clinically confirmed age-...
Ruili and Longchuan, two border counties in southwestern China, are facing epidemic control challenges due to the high rate of COVID-19 infections originating from neighboring Myanmar. Here, we aimed establish applicability wastewater environmental water surveillance SARS-CoV-2 conduct whole-genome sequencing (WGS) trace possible infection origin. In August 2021, total 72 river samples were collected 32 sampling sites. ORF1ab N genes measured by RT-qPCR. We found that 19 (26.39%) positive,...
This study mainly evaluates the clinical characteristics and chest computed tomography (CT) findings of AFB-positive AFB-negative pulmonary tuberculosis (PTB) patients to explore relationship between clinico-radiological findings. A retrospective analysis 224 hospitalized from 2018 2020 was undertaken. According AFB smear results, they were divided into (positive by Ziehl-Neelsen staining) patients' CT results laboratory test analyzed. total PTB enrolled. (n = 94, 42%) 130, 58%). had more...
Angiotensin-converting enzyme 2 (ACE2) has been identified as the key receptor of SARS coronavirus that plays a role in pathogenesis SARS. It is known ACE2 mRNA can be expressed most organs. However, protein expression not clear yet. To explore precipitating factor digestive organ damage COVID-19, this study investigated human liver, esophagus, stomach, and colon. The result showed colon, which suggests SARS-CoV-2 may enter system through cause liver gastrointestinal damage. hoped will...
This paper is to document the development process of a smartphone app track patient-reported outcomes (PROs) children with chronic diseases, and share usability study results. A multidisciplinary research team including health services researchers, pediatric nurses, software engineers worked synergistically in development. Group discussions several rounds feedback modification were conducted. Ten patients, five parents, two nurses participated study. Qualitative content analyses employed...