A5100371675- Hepatocellular Carcinoma Treatment and Prognosis
- Liver Disease Diagnosis and Treatment
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Cancer-related molecular mechanisms research
- Radiomics and Machine Learning in Medical Imaging
- Pancreatic and Hepatic Oncology Research
- Dermatologic Treatments and Research
- Hepatitis B Virus Studies
- Herpesvirus Infections and Treatments
- Cancer Mechanisms and Therapy
- Facial Rejuvenation and Surgery Techniques
- MRI in cancer diagnosis
- RNA modifications and cancer
- Liver Disease and Transplantation
- melanin and skin pigmentation
- Hepatitis C virus research
- Facial Nerve Paralysis Treatment and Research
- Liver physiology and pathology
- MicroRNA in disease regulation
- Cancer, Lipids, and Metabolism
- Ferroptosis and cancer prognosis
- Mycobacterium research and diagnosis
- Genetic and rare skin diseases.
- Ocular Disorders and Treatments
- Aldose Reductase and Taurine
Ruijin Hospital
2016-2025
Shanghai Jiao Tong University
2008-2025
Wenzhou Medical University
2024-2025
Air Force Medical University
2023-2024
Xijing Hospital
2021-2024
Southern Medical University
2018-2024
Central South University
2024
Fudan University
2022
Zhongshan Hospital
2022
Zhongshan Hospital of Xiamen University
2022
<b><i>Background:</i></b> Primary liver cancer, around 90% are hepatocellular carcinoma in China, is the fourth most common malignancy and second leading cause of tumor-related death, thereby posing a significant threat to life health Chinese people. <b><i>Summary:</i></b> Since publication <i>Guidelines for Diagnosis Treatment Liver Cancer (2017 Edition)</i> 2018, additional high-quality evidence has emerged with relevance...
Primary liver cancer, of which around 75-85% is hepatocellular carcinoma in China, the fourth most common malignancy and second leading cause tumor-related death, thereby posing a significant threat to life health Chinese people.Since publication Guidelines for Diagnosis Treatment Liver Cancer China June 2017, were updated by National Health Commission December 2019, additional high-quality evidence has emerged from researchers worldwide regarding diagnosis, staging, treatment that requires...
Portal vein tumor thrombus (PVTT) is very common and it plays a major role in the prognosis clinical staging of hepatocellular carcinoma (HCC). We have published first version guideline 2016 revised 2018. Over past several years, many new evidences for treatment PVTT become available, especially advent targeted drugs immune checkpoint inhibitors which further improved PVTT. So, Chinese Association Liver Cancer Medical Doctor 2018 to adapt development treatment. Future strategies HCC with...
A series of new N-halamine epoxide precursors, 3-glycidyl-5,5-dialkylhydantoins (GH's), has been synthesized by a very facile and economic method. Cellulose surfaces can be treated with GH's rendered biocidal exposure to halogen solutions after curing the material. The efficacy tests showed that chlorinated cellulose were antimicrobial contact times required for 6−7 log reductions Staphylococcus aureus Escherichia coli O157:H7 5−30 min. It was found in simulated washing celluloses, such as...
Lenvatinib plus an anti-PD-1 antibody has shown promising antitumor effects in patients with advanced hepatocellular carcinoma (HCC), but clinical benefit limited to a subset of patients. We developed and validated radiomic-based model predict objective response this combination therapy HCC
Abstract Background To investigate the viscoelastic signatures of proliferative hepatocellular carcinoma (HCC) using three-dimensional (3D) magnetic resonance elastography (MRE). Methods This prospective study included 121 patients with 124 HCCs as training cohort, and validation cohort 33 HCCs. They all underwent preoperative conventional imaging (MRI) tomoelastography based on 3D multifrequency MRE. Viscoelastic parameters tumor liver were quantified shear wave speed ( c , m/s) loss angle...
Abstract Background This study aimed to develop and validate a machine learning (ML)-based fusion model preoperatively predict Ki-67 expression levels in patients with head neck squamous cell carcinoma (HNSCC) using multiparametric magnetic resonance imaging (MRI). Methods A total of 351 pathologically proven HNSCC from two medical centers were retrospectively enrolled the divided into training ( n = 196), internal validation 84), external 71) cohorts. Radiomics features extracted...
Abstract Previous studies have reported that the aberrantly expressed AKR1B10 is associated with many cancer development, however functional roles of and its regulatory mechanisms in hepatocellular carcinoma (HCC) been limited studied. In this project, we identified as an oncogene HCC through tumor/normal human tissue comparison from both GEO microarray TCGA RNAseq dataset. Further experimental validations three cell lines (SMMC-7721, HePG2 HeP3B) also suggested ontogenetic functions tumor...
Abstract Systemic therapy is typically the primary treatment choice for hepatocellular carcinoma (HCC) patients with extrahepatic metastases. Some may achieve partial response (PR) or complete (CR) systemic treatment, leading to possibility of their tumor becoming resectable. This study aimed investigate whether these could longer survival through surgical resection tumor. We retrospectively collected data from 150 HCC metastases treated at 15 different centers January 1st, 2015, November...
Abstract Background To explore the value of intratumoral and peritumoral radiomics in preoperative prediction anaplastic lymphoma kinase (ALK) mutation status survival patients with lung adenocarcinoma. Methods We retrospectively collected data from 505 eligible adenocarcinoma four hospitals (training external validation sets 1–3). The CT-based features were extracted separately gross tumor volume (GTV) GTV incorporating 3-, 6-, 9-, 12-, 15-mm regions (GPTV 3 , GPTV 6 9 12 15 ), screened...
Short-term recurrence after surgery severely threatens patients' lives and leads to dismal outcomes in hepatocellular carcinoma (HCC). Our previous research proposed the abundance of binuclear hepatocytes (ABH) as an independent indicator related cytokinesis regulator Anillin significantly associated with HCC recurrence. The exact mechanism ABH modulation has not been clearly illustrated. In this study, we intensively investigated probable regulation noticed a contradiction between E2F7...
Background Fibroblast growth factor receptor-2 (FGFR-2) mutations are frequently observed in intrahepatic cholangiocarcinoma (ICC). While FGFR2-targeted therapies primarily studied advanced ICC, this report presents a rare case of locally recurrent ICC treated with systemic therapy, leading to significant tumor regression and successful R0 resection. Case presentation A 51-year-old female underwent right posterior hepatectomy cholecystectomy 2018 for ICC. In August 2022, postoperative MRI...
ABSTRACT Background Hepatocellular carcinoma (HCC) is the second leading cause of cancer‐related death in China. The rapid progress systemic therapies has led to approval many therapeutic methods that have quickly changed clinical guidelines and practices. Because high heterogeneity HCC, there are still some gaps between real‐world practice. present study surveyed experts China investigate current treatment concepts practice regarding HCC. Methods A questionnaire survey on HCC was...
Abstract Background Pathologic complete response (pCR) following preoperative systemic therapy is associated with improved outcomes after subsequent liver transplant/resection in hepatocellular carcinoma (HCC). However, the relationship between radiographic and histopathological remains unclear. Methods We retrospectively examined patients initially unresectable HCC who received tyrosine kinase inhibitor (TKI) plus anti–programmed death 1 (PD-1) before undergoing resection March 2019...
Background Pretreatment identification of microvascular invasion (MVI) in hepatocellular carcinoma (HCC) is important when selecting treatment strategies. Purpose To improve models for predicting MVI and recurrence‐free survival (RFS) by developing nomograms containing three‐dimensional (3D) MR elastography (MRE). Study Type Prospective. Population 188 patients with HCC, divided into a training cohort ( n = 150) validation 38). In the cohort, 106/150 completed 2‐year follow‐up. Field...
Systemic therapy is the standard care of unresectable hepatocellular carcinoma (uHCC), while transcatheter intra-arterial therapies (TRITs) were also widely applied to uHCC patients in Chinese practice. However, benefit additional TRIT these unclear. This study investigated survival concurrent and systemic used as first-line treatment for with uHCC.