A5006604111- Medical Imaging Techniques and Applications
- Radiomics and Machine Learning in Medical Imaging
- Radiopharmaceutical Chemistry and Applications
- Cardiac Imaging and Diagnostics
- Advanced X-ray and CT Imaging
- Advanced MRI Techniques and Applications
- Medical Imaging and Pathology Studies
- Hepatocellular Carcinoma Treatment and Prognosis
- Lung Cancer Treatments and Mutations
- MRI in cancer diagnosis
- Lung Cancer Diagnosis and Treatment
- Peptidase Inhibition and Analysis
- Cancer, Hypoxia, and Metabolism
- Radiation Dose and Imaging
- Neuroendocrine Tumor Research Advances
- Cardiovascular Function and Risk Factors
- Monoclonal and Polyclonal Antibodies Research
- Cancer Immunotherapy and Biomarkers
- Management of metastatic bone disease
- Coronary Interventions and Diagnostics
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Thyroid Cancer Diagnosis and Treatment
- Advanced Radiotherapy Techniques
- Cell Adhesion Molecules Research
- Cancer, Lipids, and Metabolism
Zhongshan Hospital
2016-2025
Fudan University
2016-2025
Shanghai Institute of Hematology
2015-2025
Shanxi Agricultural University
2023-2025
The First Affiliated Hospital, Sun Yat-sen University
2014-2024
Sun Yat-sen University
2014-2024
National Natural Science Foundation of China
2018-2022
Hudson Institute
2021
GTx (United States)
2011-2020
Creative Commons
2018
<b><i>Background:</i></b> Primary liver cancer, around 90% are hepatocellular carcinoma in China, is the fourth most common malignancy and second leading cause of tumor-related death, thereby posing a significant threat to life health Chinese people. <b><i>Summary:</i></b> Since publication <i>Guidelines for Diagnosis Treatment Liver Cancer (2017 Edition)</i> 2018, additional high-quality evidence has emerged with relevance...
Primary liver cancer, of which around 75-85% is hepatocellular carcinoma in China, the fourth most common malignancy and second leading cause tumor-related death, thereby posing a significant threat to life health Chinese people.Since publication Guidelines for Diagnosis Treatment Liver Cancer China June 2017, were updated by National Health Commission December 2019, additional high-quality evidence has emerged from researchers worldwide regarding diagnosis, staging, treatment that requires...
Inflammation and calcification concomitantly drive atherosclerotic plaque progression rupture are the compelling targets for identifying vulnerability. However, current imaging modalities vulnerable plaques often limited by inadequate specificity sensitivity. Here, we show that natural H-ferritin nanocages radiolabeled with technetium-99m (99mTc-HFn) can identify accurately localize macrophage-rich, in living mice using combined SPECT CT. Focal 99mTc-HFn uptake was observed multiple...
Accurate tumour response prediction to targeted therapy allows for personalised conversion patients with unresectable colorectal cancer liver metastases (CRLM). In this study, we aimed develop and validate a multi-modal deep learning model predict the efficacy of bevacizumab in initially CRLM using baseline PET/CT, clinical data, colonoscopy biopsy specimens.
Abstract Background The aim of this study is to conduct physical performance evaluation on the uMI550 whole-body PET/CT system according NEMA NU2-2018 standard. Methods According NU2-2018, spatial resolution, sensitivity, scatter fraction, count-rate performance, accuracy count losses and random corrections, image quality, timing resolution were evaluated. Spatial was measured by using a 22 Na point source. System sensitivity inserting an 18 F line-source in six concentric aluminum sleeves...
Abstract Purpose The purpose of this study was to investigate the image quality and diagnostic performance different reconstructions over a wide range patient body mass indices (BMIs) obtained by total-body PET/CT with ultra-low 18 F-FDG activity (0.37 MBq/kg). Methods A total 63 patients who underwent MBq/kg) were enrolled. Patients grouped their BMIs. Images reconstructed following two algorithms: ordered subset expectation maximization (OSEM) algorithm (2, 3 iterations), both time flight...
Currently, the development of novel pesticides remains a crucial initiative to address challenges agricultural pest management. In pursuit agrochemical candidates derived from plant natural products (NPs), 76 isoxazoline-hybridized honokiol/magnolol analogues were assembled via [3 + 2] dipolar cycloaddition reaction, and their pesticidal potency cytotoxicity evaluated. Bioassays revealed that 13 compounds (5d, 6k, 7b-d, 7f, 7g, 8d-f, 13f, 15d, 16h) exhibited superior larvicidal activity...
The rupture of vulnerable atherosclerotic plaques that lead to stroke and myocardial infarction may be induced by macrophage infiltration augmented the expression integrin α<sub>v</sub>β<sub>3</sub>. Indeed, angiogenesis a promising marker inflammation. In this study, an engineered α<sub>v</sub>β<sub>3</sub>–targeting PET probe, <sup>64</sup>Cu-NOTA-3-4A, derived from divalent knottin miniprotein was evaluated in mouse model for carotid plaques. <b>Methods:</b> Atherosclerotic BALB/C mice,...
BACKGROUND: Sex-specific differences in coronary phenotypes response to stress have not been elucidated. This study investigated the sex-specific computed tomography angiography-assessed mental stress. METHODS: retrospective included patients with artery disease and without cancer who underwent resting 18 F-fluorodexoyglucose positron emission tomography/computed angiography within 3 months. F-flourodeoxyglucose amygdalar uptake, an imaging biomarker of stress-related neural activity,...
The translocator protein (TSPO) positron emission tomography (PET) can noninvasively detect neuroinflammation associated with epileptogenesis and epilepsy. This study explored the role of TSPO-targeting radioligand [18F]F-TFQC, an m-trifluoromethyl ER176 analog, in PET neuroimaging epileptic rats. Initially, [18F]F-TFQC was synthesized a radiochemical yield 8%–10% (EOS), purity over 99%, specific activity 38.21 ± 1.73 MBq/nmol (EOS). After determining that exhibited good biochemical...
Purpose The objective of this study was to compare the diagnostic value obtained using single-photon emission computed tomography (SPECT)/spiral (CT) with Tc-99m methylene-diphosphonate that SPECT alone in patients spinal lesions. Methods This a retrospective 56 who underwent planar whole-body scintigraphy because bone pain or osseous lesions had been detected by other imaging techniques, for investigation metastasis extraskeletal malignancies. Only hot spots their spine and undergone...
As part of our ongoing efforts to discover novel agricultural fungicidal candidates from natural sesquiterpene lactones, in the present work, sixty-three xanthatin-based derivatives containing a arylpyrazole, arylimine, thio-acylamino, oxime, oxime ether, or ester moiety were synthesized. Their structures well characterized by 1H and 13C nuclear magnetic resonance high-resolution mass spectrometry, while absolute configurations compounds 5' 6a further determined single-crystal X-ray...