A5102784101- Hepatocellular Carcinoma Treatment and Prognosis
- Pancreatic and Hepatic Oncology Research
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Liver Disease Diagnosis and Treatment
- Cancer Research and Treatments
- Gallbladder and Bile Duct Disorders
- PI3K/AKT/mTOR signaling in cancer
- Colorectal Cancer Treatments and Studies
- Metabolism, Diabetes, and Cancer
- Spine and Intervertebral Disc Pathology
- Cancer, Lipids, and Metabolism
- Peptidase Inhibition and Analysis
- Cancer Immunotherapy and Biomarkers
- Ferroptosis and cancer prognosis
- Oral Health Pathology and Treatment
- Cancer Diagnosis and Treatment
- Cancer Mechanisms and Therapy
- Liver physiology and pathology
- Hepatitis B Virus Studies
- Intestinal Malrotation and Obstruction Disorders
- TGF-β signaling in diseases
- Connective Tissue Growth Factor Research
- Phagocytosis and Immune Regulation
- Phonocardiography and Auscultation Techniques
- Immune cells in cancer
Fudan University
2015-2025
Minhang District Central Hospital
2025
Dali University
2023-2025
Yunnan Provincial Department of Education
2025
Zhongshan Hospital
2013-2024
Shanghai Institute of Hematology
2016-2024
National Clinical Research Center for Digestive Diseases
2024
Panzhihua University
2023
Sun Yat-sen University
2008-2022
The First Affiliated Hospital, Sun Yat-sen University
2008-2022
The proteomic heterogeneity of gastric adenocarcinoma (GC) has been extensively investigated at the bulk tissue level, which can only provide an average molecular state. In this study, we collected in-depth quantitative dataset tissues and interstitial fluids (ISFs) from both poorly non-poorly differentiated GC presented a comprehensive analysis several perspectives. Comparison proteomes between ISFs revealed that ISF exhibited higher abundances proteins associated with blood microparticles,...
Recurrent oral ulcers (ROUs) of mucosa disease are difficult to cure and relapse easily, immune imLbalance or dysfunction is considered an essential factor in their occurrence recurrence. Periplaneta americana extract (PAD), a raw material used Kangfuxin Liquid Yunnan Baiyao toothpaste, contains variety growth factors such as polypeptides sticky sugar amino acids that promote tissue repair; this can encourage the granulation reduce inflammation on wound surface. This study aimed investigate...
The mechanisms of free fatty acid (FFA)-induced peripheral insulin resistance remain elusive. This study aimed to investigate the effect palmitate, a saturated acid, on glucose metabolism in C2C12 myotubes, and explore underlying mechanisms. In it, palmitate decreased insulin-stimulated uptake consumption dose-dependent manner, it reduced phosphorylation Akt at Thr308 Ser473, but had no protein expression PI3K-p85 or activity PI3K. Additionally, inhibited Src Tyr416, causing reduction...
Abstract Background Pathologic complete response (pCR) following preoperative systemic therapy is associated with improved outcomes after subsequent liver transplant/resection in hepatocellular carcinoma (HCC). However, the relationship between radiographic and histopathological remains unclear. Methods We retrospectively examined patients initially unresectable HCC who received tyrosine kinase inhibitor (TKI) plus anti–programmed death 1 (PD-1) before undergoing resection March 2019...
Objective Albumin-to-alkaline phosphatase ratio (AAPR), a newly developed blood biomarker, has been reported to have prognostic value in several types of cancer. This study aimed investigate the predictive AAPR patients with early-stage hepatocellular carcinoma (HCC) undergoing radiofrequency ablation (RFA) as initial therapy.Methods retrospective analyzed 445 diagnosed HCC RFA therapy. A series survival analyses were performed evaluate AAPR. Univariate and multivariate identify independent...
Inflammation plays a critical role in tumor metastasis. However, few inflammation-related biomarkers are currently available to predict the risk of metastasis for advanced hepatocellular carcinoma (HCC). Using huge tumors (diameter >10 cm) as model, we evaluated potential pre- and post-treatment inflammatory responses development HCC patients undergoing transarterial chemoembolization (TACE). A logistic regression model was used analyze factors. One hundred sixty-five with were enrolled...
Percutaneous thermal ablation combined with transarterial chemoembolization (TACE) becomes a treatment option for unresectable hepatocellular carcinoma (HCC). This study aims to investigate the safety and feasibility of percutaneous simultaneous TACE patients HCC ≤ 5 cm.From June 2010 February 2017, total 280 cm who underwent were included in our study. Their clinical data collected analyzed.Major complications occurred five cases (1.8%). The complete necrosis rate was 91.9%. median overall...
Background: The aim of this study was to evaluate the therapeutic efficacy and safety hepatic arterial infusion (HAI) with irinotecan, oxaliplatin, floxuridine as a firstline treatment in patients unresectable liver metastases colorectal cancer (CRC). Patients Methods: Individual were treated irinotecan (120 mg/m2), oxaliplatin (100 (500 mg/m2) via tumorsupplying arteries. Intravenous leucovorin (200 mg/day) (300 mg/m2/day) given on days 1–3 after procedure. courses repeated every 4–8 weeks....
Intrahepatic cholangiocarcinoma (iCCA) is a primary liver malignancy with poor prognosis and limited treatment. Cisplatin gemcitabine used as the standard first-line chemotherapy regimen; however, there still no robust evidence for second-line successive treatments. Although preliminary suggests vital role of precision therapy or immunotherapy in subset patients, gene alteration rate relatively low. Herein, we explored treatments using hepatic arterial infusion (HAIC) based on FOLFIRI after...
Biomimetic materials are attracting increasing attention in the field of drug delivery due to their low immunogenicity, good biocompatibility and degradability.
Liver fibrosis is the damage repair response following chronic liver diseases. Activated hepatic stellate cells (HSCs) are main extracellular matrix (ECM)-producing and key regulators in fibrosis. Periplaneta americana shows prominent antifibrotic effects fibrosis; however, underlying mechanisms remain undetermined. This study aimed to elucidate therapeutic of P. extract (PA-B) on based regulation TGF-β1/Smad signal pathway.
Purpose: The prognosis of patients with intermediate-stage hepatocellular carcinoma (HCC) treated by conventional TACE (cTACE) is greatly heterogeneous. This study aimed to develop a new survival prediction model help select who would benefit better from cTACE treatment. Methods: We collected data 848 treatment-naïve BCLC B HCC received as first-line therapy. prognostic model's variables were derived univariate and multivariate Cox regression analyses. concordance index (C-statistic)...
Takeda G protein receptor 5 (TGR5) is widely recognized as a potential drug target for the treatment of metabolic diseases. TGR5 not only regulator, but also has role that participating in developing and progressing gastrointestinal cancer. We aimed to investigate pancreatic cancer by utilizing molecular experiments liquid chromatography mass spectrometry (LC-MS) based metabolomics.Herein, we assessed proliferation, migration invasion response antagonist SBI-115 vitro experiments. Cell death...
Aberration of PI3K signaling pathway has been confirmed to be associated with several hematological malignancies including acute myeloid leukemia (AML). FD268, a pyridinesulfonamide derivative characterized by the conjugation 7-azaindole group, is newly identified inhibitor showing high potent enzyme activity at nanomole concentration. In this study, we demonstrated that FD268 dose-dependently inhibits survival AML cells efficacy superior PI-103 (pan-PI3K inhibitor) and CAL-101 (selective...
<title>Abstract</title> Recurrent oral ulcers (ROUs) of mucosa disease are difficult to cure and relapse easily, immune imLbalance or dysfunction is considered an essential factor in their occurrence recurrence. Periplaneta americana extract (PAD), a raw material used Kangfuxin Liquid Yunnan Baiyao toothpaste, contains variety growth factors such as polypeptides sticky sugar amino acids that promote tissue repair; this can encourage the granulation reduce inflammation on wound surface. This...