A5101905945- Hepatocellular Carcinoma Treatment and Prognosis
- Cancer Immunotherapy and Biomarkers
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Pancreatic and Hepatic Oncology Research
- Nanoparticle-Based Drug Delivery
- Liver Disease Diagnosis and Treatment
- Neuroendocrine Tumor Research Advances
- Nanoplatforms for cancer theranostics
- Acute Ischemic Stroke Management
- Ferroptosis and cancer prognosis
- Cancer, Lipids, and Metabolism
- Advanced biosensing and bioanalysis techniques
- Immune Cell Function and Interaction
- Cancer-related molecular mechanisms research
- RNA modifications and cancer
- Renal cell carcinoma treatment
- Cancer Cells and Metastasis
- Cancer Genomics and Diagnostics
- Gastrointestinal Tumor Research and Treatment
- Glycosylation and Glycoproteins Research
- MRI in cancer diagnosis
- Immunotherapy and Immune Responses
- RNA Interference and Gene Delivery
- Gut microbiota and health
- Viral-associated cancers and disorders
Zhongshan Hospital
2015-2025
Fudan University
2015-2025
Sun Yat-sen University
2015-2025
The First Affiliated Hospital, Sun Yat-sen University
2015-2025
Nantong University
2025
Children's Hospital of Zhejiang University
2024
Wenzhou Medical University
2018-2023
First Affiliated Hospital of Wenzhou Medical University
2018-2023
China National Center for Food Safety Risk Assessment
2021-2023
Zhejiang Sci-Tech University
2021-2023
A unique biomimetic drug-delivery system composed of 4T1-breast-cancer-cell membranes and paclitaxel-loaded polymeric nanoparticles (PPNs) (cell-membrane-coated PPNs), demonstrates superior interactions to its source tumor cells elongated blood circulation, displays highly cell-specific targeting the homotypic primary metastases, with successful inhibition growth lung metastasis breast cancer cells.
The cell-specific targeting drug delivery and controlled release of at the cancer cells are still main challenges for anti-breast metastasis therapy. Herein, authors first report a biomimetic system composed doxorubicin (DOX)-loaded gold nanocages (AuNs) as inner cores 4T1 cell membranes (CMVs) outer shells (coated surface DOX-incorporated AuNs (CDAuNs)). CDAuNs, perfectly utilizing natural with homotypic hyperthermia-responsive ability to cap DAuNs photothermal property, can realize...
Objective Our previous studies have identified CXCL8 as the crucial chemokine responsible for gastric cancer metastasis mediated by loss of RACK1. However, regulatory effect on immune surveillance in remains obscure. Design Flow cytometry analyses were performed to examine major source and phenotypes cells fresh tumour tissues from 76 patients with cancer. Real-time PCR was analyse mRNA level tissues. For immunohistochemical analyses, a total 420 undergoing curative resection enrolled. In...
Combined therapy with tyrosine kinase inhibitors (TKIs) and anti-PD-1 antibodies has shown high tumor response rates for patients unresectable hepatocellular carcinoma (HCC). However, using this treatment strategy to convert initially HCC resectable was not reported.Consecutive who received first-line combined TKI/anti-PD-1 were analyzed. Tumor resectability evaluated via imaging every 2 months (±2 weeks) RECIST v1.1. Resectability criteria (1) R0 resection could be achieved sufficient...
Abstract Background Small hepatocellular carcinoma (SHCC) is a special type of with the maximum tumor diameter ≤ 3 cm and excellent long-term outcomes. However, prognostic factors for SHCC remain controversial. The purpose this study to clarify predictive SHCC. Methods population consisted 458 patients underwent hepatectomy single between January 2006 December 2008. Clinical data (included age, gender, virus infection, serum alfa-fetoprotein level, cirrhosis, capsule, border),...
A new classification of pulmonary adenocarcinoma has been recently proposed by the International Association for Study Lung Cancer, American Thoracic Society and European Respiratory (IASLC/ATS/ERS). This study was undertaken in an attempt to explore clinical implication this Chinese patients.Two hundred ninety-two lung adenocarcinomas were reclassified strictly according IASLC/ATS/ERS two pathologists, independently. Kaplan-Meier Cox regression analyses used analyze correlation between...
The tumor growth and metastasis is the leading reason for high mortality of breast cancer. Herein, it first reported a deep tumor‐penetrating photothermal nanotherapeutics loading near‐infrared (NIR) probe potential therapy (PTT) NIR 1,1‐dioctadecyl‐3,3,3,3‐tetramethylindotricarbocyanine iodide (DiR), lipophilicfluorescent carbocyanine dye with strong light‐absorbing capability, entrapped into PTT application. DiR‐loaded (DPN) homogeneous nanometer‐sized particles mean diameter 24.5 ± 4.1...
Hepatocellular carcinoma (HCC) is the one of most common cancers and lethal diseases in world. DNA methylation alteration frequently observed HCC may play important roles carcinogenesis diagnosis.Using TCGA dataset, we classified patients into different subtypes, identified differentially methylated expressed genes, analyzed cis- trans-regulation gene expression. To find potential diagnostic biomarkers for HCC, screened HCC-specific CpGs by comparing profiles 375 samples from patients, 50...
Prolonged circulation, specific and effective uptake by tumor cells, rapid intracellular drug release are three main factors for the delivery systems to win battle against metastatic breast cancer. In this work, a microenvironment‐adaptive nanoparticle co‐loading paclitaxel (PTX) anti‐metastasis siRNA targeting Twist is prepared. The consists of pH‐sensitive core, cationic shell, matrix metalloproteinase (MMP)‐cleavable polyethylene glycol (PEG) corona conjugated via peptide linker. PEG will...
Abstract Myocardial infarction (MI) commonly leads to cardiomyocyte apoptosis and heart failure. Mangiferin is a natural glucosylxanthone extracted from mango fruits leaves, which has anti‐apoptotic anti‐inflammatory properties in experimental cardiovascular diseases. In the present study, we investigated role detailed mechanism of mangiferin MI. We used ligation left anterior descending coronary artery establish an MI model vivo, cardiomyocyte‐specific Sirt1 knockout mice were identify...
We evaluated organ-specific response rates (OSRRs) to first-line lenvatinib plus anti-PD-1 antibodies in patients with advanced hepatocellular carcinoma (HCC).
Combined treatment with tyrosine kinase inhibitors (TKI) plus anti-PD-1 antibodies showed high anti-tumor efficacy and made conversion resection possible for patients unresectable hepatocellular carcinoma (HCC). However, long-term survival has not been reported.
Increased intestinal epithelial barrier function damages caused by early weaning stress have adverse effects on swine health and feed utilization efficiency. Probiotics emerged as the promising antibiotic alternatives used for damage prevention. Our previous data showed that Lactobacillus frumenti was identified a predominant in microbiota of weaned piglets. However, whether piglets regulated L. is still unclear. Here, received PBS vehicle or suspension (2 ml, 108 CFU/ml) containing oral...
Background and Aims: Cholangiocarcinoma (CCA) is a highly heterogeneous cancer with limited understanding few effective therapeutic approaches. We aimed at providing proteogenomic CCA characterization to inform biological processes treatment vulnerabilities. Approach Results: Integrative genomic analysis functional validation uncovered perturbations downstream of driver events including DPCR1 , RBM47 mutations, SH3BGRL2 copy number alterations, FGFR2 fusions in CCA. Proteomic clustering...
Recent studies have highlighted the distinct value of tertiary lymphoid structure (TLS) for immunotherapeutic response prediction. However, it remains unclear whether TLS could play such roles in gastric cancer (GC).In this study, tumor tissue slices from 292 GC patients Zhongshan Hospital were firstly reviewed to explore correlation between and clinical characteristics. Subsequently, we curated 38 reported genes that may function as triggers performed consensus molecular subtyping public...