A5101964837- Advanced Surface Polishing Techniques
- Hepatocellular Carcinoma Treatment and Prognosis
- Advanced machining processes and optimization
- Diamond and Carbon-based Materials Research
- GaN-based semiconductor devices and materials
- Organic Light-Emitting Diodes Research
- Pancreatic and Hepatic Oncology Research
- Glycosylation and Glycoproteins Research
- Acoustic Wave Resonator Technologies
- Conducting polymers and applications
- Renal cell carcinoma treatment
- Microfluidic and Bio-sensing Technologies
- FOXO transcription factor regulation
- Orbital Angular Momentum in Optics
- Transition Metal Oxide Nanomaterials
- Monoclonal and Polyclonal Antibodies Research
- Lung Cancer Research Studies
- Knowledge Management and Sharing
- Blood Pressure and Hypertension Studies
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Semiconductor materials and devices
- Metal and Thin Film Mechanics
- Innovation and Knowledge Management
- Liver Disease Diagnosis and Treatment
- Histone Deacetylase Inhibitors Research
State Key Laboratory of Chemical Engineering
2025
Shanghai Institute of Materia Medica
2021-2025
Chinese Academy of Sciences
2013-2025
Advanced Research Institute
2025
Shanghai University
2009-2023
Putian University
2023
Fudan University
2002-2022
Zhongshan Hospital
2006-2022
Ministry of Education of the People's Republic of China
2020-2022
University of Shanghai for Science and Technology
2021
Abstract The majority of patients with epithelial ovarian cancer are diagnosed at a late stage when the peritoneal metastases exist; however, there is little knowledge metastatic process in this disease setting. In study, we report identification long noncoding RNA LINC00092 as nodal driver progression mediated by cancer-associated fibroblasts (CAF). Prometastatic properties CAFs vitro and vivo were found to associate elevated expression chemokine CXCL14. clinical specimens, levels CXCL14...
Combined treatment with tyrosine kinase inhibitors (TKI) plus anti-PD-1 antibodies showed high anti-tumor efficacy and made conversion resection possible for patients unresectable hepatocellular carcinoma (HCC). However, long-term survival has not been reported.
Hexagonal AlN (h-AlN) nanowires with an average diameter of around 15 nm have been prepared by extended vapor–liquid–solid growth technique and characterized X-ray diffraction, transmission electron microscopy, energy dispersive analysis, Raman spectroscopy field emission measurements. This preparation is a rather simple route for bulk fabrication h-AlN nanowires. The promising property observed points to the important application potential this material.
Albumin-binding prodrugs have been explored to overcome the limitations of small-molecule anticancer chemotherapy agents, such as inadequate physiological and pharmaceutical compatibility, well rapid renal clearance. Herein, we investigated two endogenous albumin-binding prodrugs, M-g-SN38 S-g-SN38, forming macromolecular conjugates. Both exhibited robust stability in murine human plasma, crucial for their therapeutic potential. Selective activation by β-glucuronidase ensures minimal...
This research examines how knowledge management influences new product development (NPD) in technology ventures. Researchers demonstrate that is a critical antecedent of NPD. However, few studies have explored the role NPD from behavioral perspective. By employing experiential learning theory, this develops conceptual model to study relationships between management, behavior arising failures, and ventures' performance. Using sample 176 high‐tech ventures, theoretical examined. The findings...
Aberrantly activated FOXM1 (forkhead box protein M1) leading to uncontrolled cell proliferation and dysregulation of transcription network occurs in 84% ovarian cancer cases. It was demonstrated that thiostrepton, a thiazole antibiotic, decreases expression. We aimed determine if targeting the pathway with thiostrepton could improve efficacy paclitaxel cisplatin human ascites cells ex vivo.Human lines patients' were treated paclitaxel, cisplatin, or combination for 48 hours, cytotoxicity...
Polycrystalline hollow AlN nanospheres with diameters ranging from 20 to 200 nm and shell thickness of about 10 were successfully synthesized through the reaction irregular Al nanopowder a CH4–NH3 mixture at around 1000 °C by self-templated method. The products well characterized X-ray diffraction, high-resolution transmission electron microscopy, Raman spectroscopy photoluminescence measurements. properties showed routine blue emissions for nanoparticles as an unusual green emission 533 nm,...
Chemotherapy may still be an essential component to treat cancer in combination with new targeted therapies. But chemotherapy needs get smarter order make those regimens more effective and also tolerable, particularly for aging population. We describe the first time synthesis pharmacological testing of a fusion molecule comprising alkylator bendamustine HDAC-inhibitor vorinostat. The drug was designed allow exploitation both mechanisms action simultaneously goal provide superior efficacy...
Gene therapy is a very promising technology for treatment of pancreatic ductal adenocarcinoma (PDAC). However, its application has been limited by the abundant stromal response in tumor microenvironment. The aim this study was to prepare dendrimer-based gene-free loading vector with high permeability stroma and explore an imaging-guided local gene delivery strategy PDAC promote efficiency targeted delivery.The experimental protocol approved animal ethics committee Zhongshan Hospital, Fudan...