A5100392431- Hepatocellular Carcinoma Treatment and Prognosis
- Cancer Mechanisms and Therapy
- Liver Disease Diagnosis and Treatment
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Cancer, Lipids, and Metabolism
- Remote Sensing and Land Use
- Robotics and Sensor-Based Localization
- Cancer, Hypoxia, and Metabolism
- Anomaly Detection Techniques and Applications
- Video Surveillance and Tracking Methods
- Image Retrieval and Classification Techniques
- Advanced Image and Video Retrieval Techniques
- Lung Cancer Treatments and Mutations
- Infrared Target Detection Methodologies
- Ferroptosis and cancer prognosis
- EFL/ESL Teaching and Learning
- Stock Market Forecasting Methods
- Advanced Clustering Algorithms Research
- Cellular Mechanics and Interactions
- Advanced Vision and Imaging
- Renal cell carcinoma treatment
- Gait Recognition and Analysis
- Neural Networks and Applications
- Liver physiology and pathology
- Inflammatory Biomarkers in Disease Prognosis
West China Second University Hospital of Sichuan University
2025
Chengdu Women's and Children's Central Hospital
2025
Xuzhou Medical College
2025
Sichuan University
2025
Guangzhou Metro Group (China)
2024
Guangzhou Metro Design & Research Institute
2024
Shanghai University of Traditional Chinese Medicine
2024
Guangdong Polytechnic of Science and Technology
2024
Fudan University
2013-2023
Alibaba Group (China)
2023
Abstract Purpose: The survival of patients with hepatocellular carcinoma (HCC) recurrence after curative resection is usually poor. We sought to evaluate the safety and efficacy adjuvant transarterial chemoembolization (TACE) in HBV-related HCC an intermediate (a single tumor larger than 5 cm without microvascular invasion) or high risk invasion, two three tumors) recurrence. Experimental Design: In this randomized phase 3 trial, 280 eligible were assigned TACE (n = 140) no treatment...
Abstract Background Sorafenib is the first agent that has demonstrated an improved overall survival benefit in advanced hepatocellular carcinoma (HCC), setting a new standard for first-line treatment. However, no one yet been able to predict sensitivity sorafenib. Pre-treatment pERK level shown be associated with favorable response such therapy phase II clinical study, indicating may potential biomarker treatment of HCC Methods The effects sorafenib and 5-fluorouracil (5-FU) on cell...
Matrix stiffness as an important physical attribute of extracellular matrix exerts significant impacts on biological behaviors cancer cells such growth, proliferation, motility, metabolism and invasion. However, its influence stemness still remains elusive. Here, we explore whether stiffness-mediated effects characteristics occur in HCC cells. As the substrate increased, exhibited high proportion with CD133(+)/EpCAM(+), expression levels CD133, EpCAM, Nanog SOX2, greater self-renewing...
Abstract Background This study was designed to evaluate the effectiveness of radiofrequency ablation in patients with intermediate (BCLC B) stage hepatocellular carcinoma who underwent transcatheter arterial chemoembolization. Methods Included this were 211 HCC initial chemoembolization and potentially amendable for (single tumor diameter 5-8 cm, median 6.0 cm; 2–5 multiple nodules less than 5 cm) between January 2005 December 2011. According inclusion exclusion criteria, 55 treated...
To examine the knowledge, attitudes and willingness of caregivers preterm infants toward autism spectrum disorder (ASD).
This study aims to assess the serum levels of pepsinogen (PG)I, PG II, and gastrin (G17) in patients with gastric intestinal metaplasia (GIM) evaluate their correlation demographic characteristics. A total 247 normal controls (NC) 240 diagnosed GIM were enrolled this study. All participants underwent a gastroscopy procedure followed by pathological examination for diagnosis confirmation. The expression level PGI, G 17 was detected fluorescence immunochromatography Hp infection 13-carbon...
Increased stromal stiffness is associated with hepatocellular carcinoma (HCC) development and progression. However, the molecular mechanism by which matrix stimuli modulate HCC progress largely unknown. In this study, we explored whether stiffness-mediated effects on osteopontin (OPN) expression occur in cells. We used a previously reported vitro culture system tunable found that OPN was remarkably upregulated cells increasing stiffness. Furthermore, phosphorylation level of GSK3β nuclear...
Inflammation is particularly strong in huge hepatocellular carcinoma (HCC). However, it unclear whether the platelet-to-lymphocyte ratio (PLR), as an inflammatory-related marker, can predict survival of patients with HCC. In this study, we enrolled 291 HCC (diameter over 10 cm) who were undergoing repeated transarterial chemoembolization (TACE) at our institute. The baseline PLR was calculated from complete serum blood counts before first chemoembolization. We found that a cutoff value 150...
Evidence suggests that many types of cancers are composed different cell types, including cancer stem cells (CSCs). We have previously shown the chemotherapeutic agent oxaliplatin induced epithelial-mesenchymal transition, which is thought to be an important mechanism for generating CSCs. In present study, we investigate whether oxaliplatin-treated tissues possess characteristics CSCs, and explore resistance in these tissues.Hepatocellular carcinoma (MHCC97H cells) were subcutaneously...
Accumulating evidence suggests platelets play critical roles in tumor metastasis. Moreover, the role of metastasis is partially correlated with inflammation. However, regarding contribution to hepatocellular carcinoma (HCC) lacking. This study investigated association between and metastatic risk HCC.We used huge HCC (diameter over 10 cm), a subgroup strong inflammatory background, as model evaluate potential predictive platelet-related biomarkers for patients undergoing transarterial...
Abstract Background Recent studies suggest that a combination of radiofrequency ablation (RFA) and transarterial chemoembolization (TACE) may have theoretical advantages over TACE alone for treatment hepatocellular carcinoma (HCC). The purpose this study was to evaluate the effectiveness safety following first-line in management HCC beyond Milan Criteria. Methods Forty-five patients who consecutively underwent RFA criteria were enrolled study. performed within 1–2 months after had incomplete...
Abstract Background Recently, a phase II clinical trial in hepatocellular carcinoma (HCC) has suggested that the combination of sorafenib and 5-fluorouracil (5-FU) is feasible side effects are manageable. However, preclinical experimental data explaining interaction mechanism(s) lacking. Our objective to investigate anticancer efficacy mechanism combined 5-FU therapy vitro HCC cell lines MHCC97H SMMC-7721. Methods Drug on proliferation were evaluated by viability assays. Combined-effects...
Activated hepatic stellate cells (aHSCs) play an important role in the progression of hepatocellular carcinoma (HCC). Here, we determined if cytokines secreted response to herbal compound "Songyou Yin" (SYY) treatment aHSCs could influence invasiveness and metastatic capabilities hepatoma cells.Primary rat (HSCs) were isolated, activated, divided into SYY treated untreated (nSYY) groups, conditioned media (CM-SYY CM-nSYY, respectively) collected. The cell line, McA-RH7777 was cultured for 4...
This study presents a novel risk-assessment methodology for deep foundation pit projects in karst regions, aimed at enhancing project safety and decision-making processes. approach amalgamates fuzzy dynamic Bayesian networks with refined Dempster–Shafer (DS) evidence theory to tackle the intricate uncertainties present such contexts. A comprehensive risk index system, derived from historical accident cases, relevant standards, literature, encompasses environmental, design, construction,...
The survival benefits of sorafenib treatment for patients with hepatocellular carcinoma (HCC) are limited due to drug resistance and side effects. Therefore, combinations other low toxicity drugs, including arsenic trioxide (As2O3) require investigation. present study aimed evaluate the potency apoptosis-induction by As2O3/sorafenib in HCC cell lines, Huh7, 97H freshly-isolated cells, also elucidate underlying mechanism. A total 10 were enrolled study. Freshly-isolated cells purified from...