A5100419299- Cancer-related molecular mechanisms research
- MicroRNA in disease regulation
- Fibroblast Growth Factor Research
- Circular RNAs in diseases
- Liver Disease Diagnosis and Treatment
- Epigenetics and DNA Methylation
- RNA modifications and cancer
- Autophagy in Disease and Therapy
- Hepatocellular Carcinoma Treatment and Prognosis
- Melanoma and MAPK Pathways
- RNA Research and Splicing
- Kruppel-like factors research
- Luminescence and Fluorescent Materials
- Cancer Cells and Metastasis
- Acute Ischemic Stroke Management
- Nutrition and Health in Aging
- Protein Degradation and Inhibitors
- Cancer Mechanisms and Therapy
- Hepatitis B Virus Studies
- Pregnancy and preeclampsia studies
- Diet and metabolism studies
- Ubiquitin and proteasome pathways
- Curcumin's Biomedical Applications
- Cancer therapeutics and mechanisms
- Cancer, Hypoxia, and Metabolism
Sichuan University
2016-2025
Chinese Center For Disease Control and Prevention
2024-2025
Zhujiang Hospital
2025
Southern Medical University
2021-2025
Second Affiliated Hospital of Zhejiang University
2019-2025
Children's Hospital of Zhejiang University
2025
Chongqing Medical University
2022-2025
Capital Normal University
2025
Guangzhou University
2007-2025
Children's Hospital of Chongqing Medical University
2025
The mechanism of Bax/Bak activation remains a central question in mitochondria-dependent apoptotic signaling. While it is established that all proapoptotic Bcl-2 homology 3 (BH3)-only proteins bind and neutralize the anti-apoptotic family proteins, how this neutralization leads to has been actively debated. Here, genome editing was used generate cells deficient for eight BH3-only (OctaKO) those lack entire (Bcl-2 allKO). Although OctaKO were resistant most stimuli tested, they underwent...
Advanced metastatic prostate cancer (PCa) is a fatal disease, with only palliative therapeutic options. Though almost 80% of cases PCa present bone metastasis, our current understanding the molecular mechanisms that govern this dissemination remains fragmentary. The main objective study was to identify microRNA (miRNA) genes regulate PCa.miRNA expression profiling done in human cell lines dysregulated miRNA components advanced PCa. miR-203 assessed carcinoma and clinical specimens by...
Abstract Purpose: The survival of patients with hepatocellular carcinoma (HCC) recurrence after curative resection is usually poor. We sought to evaluate the safety and efficacy adjuvant transarterial chemoembolization (TACE) in HBV-related HCC an intermediate (a single tumor larger than 5 cm without microvascular invasion) or high risk invasion, two three tumors) recurrence. Experimental Design: In this randomized phase 3 trial, 280 eligible were assigned TACE (n = 140) no treatment...
Hypertensive disorders of pregnancy (HDP) are a group medical complications in and also risk factor for severe outcomes, but it lacks large-scale epidemiological investigation recent years. This survey represents multicenter cross-sectional retrospective study to estimate the prevalence analyze factors HDP among pregnant women who had referred delivery between January 1st 2011 December 31st China Mainland. A total 112,386 were investigated from 38 secondary tertiary specialized or general...
Objective: To estimate the infection rate of close contacts COVID-19 cases, and to evaluate risk under different exposure conditions. Methods: A prospective study was used conduct continuous quarantine medical observations people infected with COVID-19, collect epidemiological, clinical manifestations, laboratory test data exposures. Results: The epidemiological curve in Ningbo showed persistent human-to-human characteristics. total 2 147 were tracked investigated. 6.15%. rates confirmed...
Abstract Reversion mutations in BRCA1 or BRCA2 are associated with resistance to PARP inhibitors and platinum. To better understand the nature of these mutations, we collated, codified, analyzed more than 300 reversions. This identified reversion “hotspots” “deserts” regions encoding N C terminus, respectively, BRCA2, suggesting that pathogenic may be at higher lower risk reversion. Missense splice-site BRCA1/2 also appeared less likely revert truncating mutations. Most reversions were...
Organic luminescent materials that can simultaneously achieve multimode mechanochromism and its water-vapor-induced recovery are desirable for practical applications but rarely reported. Herein, an amphiphilic compound, 4-(9H-carbazol-9-yl)-1-(2-hydroxyethyl)pyridin-1-ium bromide (CPAB), is designed by integrating a lipophilic aromatic unit hydrophilic end in the molecular architecture. Self-recovered from brown to cyan observed upon mechanical grinding air. Comprehensive research X-ray...
Abstract The stimulus‐responsive room temperature phosphorescent (RTP) materials have endowed wide potential applications. In this work, by introducing naphthalene and spiropyran (SP) into polyacrylamide as the energy donor acceptor respectively, a new kind of brilliant dynamic color‐tunable amorphous copolymers were prepared with good stability processibility, afterglow emissions from green to orange in response stimulus photo or acid, thanks multi‐responsibility SP transfer between SP....
Glioblastoma is one of the most aggressive human cancers with poor prognosis, and therefore a critical need exists for novel therapeutic strategies management glioblastoma patients. Itraconazole, traditional antifungal drug, has been identified as potential anticancer agent due to its inhibitory effects on cell proliferation tumor angiogenesis; however, molecular mechanisms involved are still unclear. Here, we show that itraconazole inhibits cells both in vitro vivo. Notably, demonstrate...
The minichromosome maintenance (MCM) gene family is essential for DNA replication and frequently upregulated in various cancers. Here, we examined the role of MCM2 prostate cancer effect microRNA-1296 (miR-1296), genistein, trichostatin A (TSA) on MCM complex. Profiling results showed that expression genes was higher tumor samples. Genistein TSA significantly downregulated all genes. Genistein, TSA, small interfering RNA duplexes caused a significant decrease S phase cell cycle. There also...
Severe acute kidney injury (AKI) after cardiac surgery is associated with poor clinical outcomes. This study evaluated the potential use of miR-21 as a risk marker for postoperative AKI progression and other outcomes.The included 120 adult patients undergoing surgery: 40 non-AKI controls, 39 progressive AKI, 41 non-progressive AKI. Urine plasma levels were assessed by quantitative real-time PCR (RT-qPCR). Associations between determined estimating areas under receiver operating...
An apparent increase in the frequency of human adenovirus type 4 (HAdV-4) infections among general populations has been observed over past 10 years. However, available epidemiological data that may reflect previous viral circulation and assist predicting potential outbreaks are sparse, particularly mainland China Africa. In this study, a convenient neutralization assay for use surveillance historical HAdV-4 was established based on recombinant luciferase-expressing virus. Subsequently,...