A5101756023- Fungal Biology and Applications
- Metabolism, Diabetes, and Cancer
- Polysaccharides and Plant Cell Walls
- Lipid metabolism and disorders
- Medicinal Plants and Bioactive Compounds
- Alzheimer's disease research and treatments
- Adipose Tissue and Metabolism
- Advanced Glycation End Products research
- Traditional Chinese Medicine Studies
- Genetics, Aging, and Longevity in Model Organisms
- Autophagy in Disease and Therapy
- Cytomegalovirus and herpesvirus research
- Biochemical effects in animals
- Spine and Intervertebral Disc Pathology
- Chronic Disease Management Strategies
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Environmental Quality and Pollution
- Protein Tyrosine Phosphatases
- Liver Disease Diagnosis and Treatment
- Blood Pressure and Hypertension Studies
- Diabetes Management and Education
- Machine Learning in Healthcare
- Sodium Intake and Health
- RNA modifications and cancer
- Chronic Kidney Disease and Diabetes
Shanghai University of Traditional Chinese Medicine
2013-2024
Yueyang Hospital
2013-2024
China Academy of Space Technology
2024
Soochow University
2021-2022
Wuxi No.2 People's Hospital
2021
Shanghai Jiao Tong University
2019
Fudan University
2019
Huashan Hospital
2019
University of Benin
2019
Shanghai University
2012-2015
A schematic diagram showing the IRS1-GLUT4 insulin signaling pathway influenced by PTP1B and FYGL in L6 cells.
Protein tyrosine phosphatase 1B (PTP1B) is implicated in the negative regulation of insulin signalling pathway by dephosphorylating receptor (IR) and IR substrates. Ganoderma lucidum has traditionally been used for treatment diabetes Chinese medicine; however, its anti-diabetic potency mechanism vivo still unclear. Our previously published study reported a novel proteoglycan PTP1B inhibitor, named Fudan-Yueyang- ( FYGL ) from G. , with half-maximal inhibitory concentration (IC 50 value 5·12...
The prevention of postprandial hyperglycemia and diabetic complications is crucial for diabetes management. Inhibition α-glucosidase to slow carbohydrate metabolism a strategy alleviate hyperglycemia. In addition, suppression non-enzymatic glycation can diminish the advanced end products reduce oxidative stress inflammation, thereby preventing complications. this study, an anti-oxidative proteoglycan (named FYGL) extracted from Ganoderma lucidum was investigated in vitro its inhibitory...
Abstract The abnormal fibrillation of human islet amyloid polypeptide (hIAPP) is associated with development type II diabetes mellitus (T2DM). (−)‐Epigallocatechin gallate (EGCG) can bind proteins to inhibit the these proteins. However, mechanic detail EGCG inhibiting formation still unclear at molecular level. In present work, we sought investigate effect on amidated hIAPP (hIAPP‐NH 2 ) and aggregation by using spectroscopic microscopic techniques, also gain insights into interaction 22–27...
Obesity is often accompanied by metabolic disorder and insulin resistance, resulting in type 2 diabetes. Based on previous findings, FYGL, a natural hyperbranched proteoglycan extracted from the G. lucidum fruiting body, can decrease blood glucose reduce body weight diabetic mice. In this article, underlying mechanism of FYGL ameliorating obesity-induced diabetes was further investigated both vivo vitro. upregulated expression genes related to fatty acid biosynthesis, β-oxidation...
A lower dose of trehalose inhibits or delays, while higher promotes the hIAPP fibrillation and aggregation.
The abnormal fibrillation of human islet amyloid polypeptide (hIAPP) has been implicated in the development type II diabetes. Aluminum is known to trigger structural transformation many proteins and induce formation toxic aggregate species. (−)-epigallocatechin gallate (EGCG) considered capable binding both metal ions with inhibitory effect on proteins. However, Al(III)/EGCG complex hIAPP unclear. In present work, we sought view insight into structures properties Al(III) EGCG by using...
Nonalcoholic steatohepatitis (NASH) is a highly prevalent metabolic disorder. Currently, there are no effective pharmacotherapeutic options for preventing and treating NASH. Portulaca oleracea L. (POL) an edible herb that has been used some disorders in China, but the bioactive constituents POL related mechanisms NASH still unclear. Here, comprehensive research strategy was to identify core genes key NASH, via integrating bioinformatics analysis experimental pharmacology both vitro vivo. The...
Protein tyrosine phosphatase 1B (PTP1B) is a key negative regulator of insulin and an effective target for the treatment type 2 diabetes (T2D). A natural hyperbranched proteoglycan extracted from Ganoderma lucidum, namely, Fudan-Yueyang G. Lucidum (FYGL), was demonstrated capable inhibiting activity PTP1B. Here, to identify active components FYGL, three different components, polysaccharide FYGL-1, proteoglycans FYGL-2, FYGL-3, were isolated then, protein moiety FYGL-3 further separated,...
The pathogenesis of intervertebral disc degeneration (IDD) is complex and remains unclear. Nucleus pulposus stem cells (NPSCs) annulus fibrosus (AFCs) play a critical role in the maintenance structure function. Exosome-mediated miRNAs regulate cell proliferation, differentiation, apoptosis, degradation. However, it not clear whether degenerative disc-derived nucleus (D-NPSCs) can function AFCs by delivering exosomes. Here, we show that exosomes secreted derived from (D-DPSC-exo) exacerbate...
Type 2 diabetes (T2D) results from both insulin resistance and pancreatic β-cell dysfunction. A natural proteoglycan extracted Ganoderma lucidum, namely, FYGL, has been demonstrated to be capable of ameliorating in previous work. In this work, a T2D rat model induced by streptozocin (STZ) high-fat diet was used investigate the effects FYGL on functions, transcriptomics pancreas biological processes (BP) signal pathways influenced gene basis. Furthermore, were verified histopathological...
A proteoglycan, namely FYGL extracted from Ganoderma lucidum, was proved previously efficient for anti-diabetes in vivo. However, many medicine functions of have not been revealed, such as immunoregulation, an important function the traditional Chinese medicine. In this work, we firstly investigated distribution orally administrated by mice and found that available small intestine viscera organs enriched mostly liver. Consequently, studied immunoregulation mechanism RAW 264.7 macrophages....
The Traditional Chinese Medicine, Ganoderma lucidum, has been widely used for its immunity-related and anti-cancer effects. Fudan-Yueyang-Ganoderma lucidum (FYGL) is a proteoglycan, extracted from that shown safe anti-diabetic activity in vivo. present study demonstrated FYGL could selectively inhibit the viability of PANC-1 BxPC-3 pancreatic cancer cells dose dependent manner, but not Mia PaCa-2 HepG2 liver cells. In addition, migration colony formation, promote apoptosis cells, Further...
Hypertension is a chronic disease with high prevalence, and associated risk of vascular premature death. Traditional Chinese medicine has been administered to treat hypertension for many years. In the present study, effects Yiqi Huaju formula (YQ; compound used in traditional herbal medicine) were observed salt‑sensitive hypertension, which was induced by high‑salt high‑fat (HSF) diet potential mechanism investigated. YQ prepared from five plant extracts dissolved normal sodium chloride...
Hospitalized geriatric patients are a highly heterogeneous group often with variable diseases and conditions. Physicians, geriatricians especially, devoted to seeking non-invasive testing tools support timely, accurate diagnosis. Chinese tongue diagnosis, mainly based on the color texture of tongue, offers unique solution. To develop assessment tool using machine learning in supporting diagnosis elderly, we created an annotated dataset 15% 688 (=100) images collected from hospitalized...
The steatosis and resultant oxidative stress apoptosis play the important roles in progression of nonalcoholic fatty liver disease (NAFLD), therefore, searching for effective drugs against NAFLD has been a hot topic. In this work, we investigated hyperbranched proteoglycan, namely FYGL extracted from Ganoderma lucidum, inhibiting palmitic acid (PA)-induced HepG2 hepatocytes. compose hydrophilic polysaccharide lipophilic protein. Both moieties conclude reductive residues, such as glucose...